The therapeutic effects of olive leaf extract on Leishmania major infection in BALB/c mice

Year 2017, Volume: 21 Issue: 4, 837 - 842, 01.12.2017

Farnaz Kheırandısh Hossein Mahmoudvand Ali Khamesıpour Farzad Ebrahımzadeh Farnaz Behrahı Setareh Rezaeı Bahram Delfan

Abstract

At present, no effective vaccine has been found for CL; thus,

the upgrading and improvement of the present drugs and

development of the novel agents have been demonstrated to

be the merely control choice for this disease. The present study

aims to evaluate the effects of olive leaf extract (Olea europaea

L. OLE) on Leishmania major infection in BALB/c mice. OLE

tested on cutaneous leishmaniasis (CL) in male BALB/c mice

with L. major promastigotes (MRHO/IR/75/ER) at the doses of

10, 20, and 30 mg/kg. Results demonstrated that after treatment

of the groups with the concentrations of 10, 20, and 40 mg/

kg of OLE, mean diameter of lesions was reduced by 2.16,

5.87, and 7.61 cm, respectively. Moreover, after 4 weeks of

treatment, 83.3%, 66.64%, and 33.32% recovery was observed

in the infected mice treated with 40, 20, and 10 mg/kg of OLE,

respectively. In conclusion, the present study showed OLE has

potent therapeutic effects on cutaneous leishmaniasis.

Keywords

Olive; Leishmania; mice; cutaneous leishmaniasis; in vivo

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