Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. & Heldr. endemic to Turkey

Year 2017, Volume: 21 Issue: 4, 898 - 905, 01.12.2017

Ebru Deveci Gülsen Tel-çayan Hasan Yıldırım Mehmet Emin Duru

Abstract

The objective of this study was to investigate the chemical

composition, antioxidant, anticholinesterase and anti-urease

activities of essential oil, hexane, acetone and methanol extracts

of Sideritis pisidica Boiss. & Heldr. The essential oil and fatty

acid composition were analyzed by GC and GC/MS. δ-Cadinene

(19.5 %), T-cadinol (16.7 %) and β-cubebene (10.4 %) were

identified as the main compounds of the essential oil whereas

the most abundant compounds of fatty acids were found as

linolenic (42.7 %), palmitic (31.3 %) and linoleic (13.4%) acids.

The methanol extract demonstrated the highest antioxidant

activity in all tests, except for metal chelating assay. The hexane

extract was found to be significantly active in metal chelating

(IC50: 22.97±1.36 μg/mL), acetylcholinesterase (62.54±0.88 %)

and urease inhibitory (78.93±0.17 %) assays. These results show

that the Sideritis pisidica could be used as the potential source of

natural products in the food and pharmaceutical areas.

Keywords

Sideritis pisidica; essential oil; fatty acid; antioxidant activity; anticholinesterase activity; anti-urease activity

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