Synthesis and antibacterial activity of hnew hydrazide-hydrazones derived from Benzocaine

Year 2017, Volume: 21 Issue: 4, 961 - 966, 01.12.2017

Muhammed İhsan Han Güler Gürol Temel Yıldırım Sadık Kalaycı Fikrettin Şahin Ş. Güniz Küçükgüzel

Abstract

A novel series of new eleven benzocaine hydrazide derivatives, N-(4-{[2-(nonsubstituted/ substitutedfuryl/ phenyl/ pyridinyl/

thienyl/ pyrrole)methylidene]hydrazinyl] carbonyl}phenyl)

benzamides [3a-k] have been synthesized in this study. The

structures of the new compounds were determined by spectral

(FT-IR and 1H-NMR) methods and their purity was proven

by elemental analysis and thin layer chromatography. These

compounds were evaluated for in vitro antibacterial activity

by using micro-well dilution method against Escherichia coli

ATCC 10536, Escherichia coli ATCC 15442, Staphylococcus

aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442,

Acinetobacter baumannii , Klebsiella pneumonia ATCC 13883.

Keywords

Antibacterial activity; Benzocaine; hydrazidehydrazone; azomethine.

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