The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster

Year 2017, Volume: 21 Issue: 4, 987 - 991, 01.12.2017

Maxim V. Trushın Raisa G. Khamıdullına Oleg V. Ardashov Konstantin P. Volcho Nariman F. Salakhutdınov

Abstract

Adequate treatment of Parkinson’s disease is an important

medical issue. Patients are suffered from numerous side

effects of the widely used drugs. It has been found recently

that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)

cyclohex-3-ene-1,2-diol and its diacetate demonstrate high

antiparkinsonian activity in some animal models. At the same

time, their genetic safety was not studied yet. The aim of this

research was to investigate the effect of these compounds with

antiparkinsonian activities on reproduction of D. melanogaster.

Over 4000 of fruitflies cultivated under the action of these

compounds were analyzed. It was found that the chemicals

did not provoke genetic mutations or alter reproduction of

D. melanogaster. The possible explanations for the detected

phenomena are provided. It was found that the compounds do

not affect fertility in Drosophila..

Keywords

Parkinson’s disease; fertility; drosophila; (1R, 2R, 6S)- 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1, 2-diol; acetate; terpene

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