Glucosamine: Production and applications

Ali Eslem Kadak; Aygül Küçükgülmez; Mehmet Çelik; Claudia Plinz

doi:10.33714/masteb.1907073

Glucosamine: Production and applications

Abstract

Glucosamine, an essential amino monosaccharide derived from chitinous biomass, serves as a primary substrate for the synthesis of glycosaminoglycan chains in human cartilage. While naturally occurring in the body, its commercial production primarily involves the chemical or enzymatic degradation of shellfish waste. This review evaluates the efficacy of its four prevalent forms; glucosamine, glucosamine hydrochloride, glucosamine sulphate, and N-acetyl glucosamine with a focus on their therapeutic mechanisms. Specifically, glucosamine derivatives manage osteoarthritis and rheumatoid arthritis by promoting cartilage repair and exerting potent anti-inflammatory effects, while also showing promise in treating cardiovascular, neurological, and dermatological conditions. Despite its $3.5 billion global market value, industrial production faces significant feasibility challenges, including the high cost of enzymatic processes and the environmental impact of chemical deacetylation waste. Furthermore, while generally recognized as a safe dietary supplement by the USFDA, clinical application must account for potential allergenic reactions in individuals with shellfish sensitivities and monitor long-term toxicological profiles to ensure patient safety.

Keywords

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Details

Primary Language

English

Subjects

Agricultural Marine Biotechnology

Journal Section

Review

Authors

Ali Eslem Kadak ^*
0000-0002-7128-9134
Türkiye

Aygül Küçükgülmez
0000-0001-5419-5921
Türkiye

Mehmet Çelik
0000-0003-4330-2490
Türkiye

Claudia Plinz
0009-0008-3648-9721
Germany

Early Pub Date

June 28, 2026

Publication Date

-

Submission Date

March 11, 2026

Acceptance Date

June 27, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.33714/masteb.1907073

IZ

https://izlik.org/JA62KT62LS

Cite

RIS / Bibtex

APA

Kadak, A. E., Küçükgülmez, A., Çelik, M., & Plinz, C. (2026). Glucosamine: Production and applications. Marine Science and Technology Bulletin, Advanced Online Publication, 157-171. https://doi.org/10.33714/masteb.1907073

AMA

1.Kadak AE, Küçükgülmez A, Çelik M, Plinz C. Glucosamine: Production and applications. Mar. Sci. Tech. Bull. 2026;(Advanced Online Publication):157-171. doi:10.33714/masteb.1907073

Chicago

Kadak, Ali Eslem, Aygül Küçükgülmez, Mehmet Çelik, and Claudia Plinz. 2026. “Glucosamine: Production and Applications”. Marine Science and Technology Bulletin, no. Advanced Online Publication: 157-71. https://doi.org/10.33714/masteb.1907073.

EndNote

Kadak AE, Küçükgülmez A, Çelik M, Plinz C (June 1, 2026) Glucosamine: Production and applications. Marine Science and Technology Bulletin Advanced Online Publication 157–171.

IEEE

[1]A. E. Kadak, A. Küçükgülmez, M. Çelik, and C. Plinz, “Glucosamine: Production and applications”, Mar. Sci. Tech. Bull., no. Advanced Online Publication, pp. 157–171, June 2026, doi: 10.33714/masteb.1907073.

ISNAD

Kadak, Ali Eslem - Küçükgülmez, Aygül - Çelik, Mehmet - Plinz, Claudia. “Glucosamine: Production and Applications”. Marine Science and Technology Bulletin. Advanced Online Publication (June 1, 2026): 157-171. https://doi.org/10.33714/masteb.1907073.

JAMA

1.Kadak AE, Küçükgülmez A, Çelik M, Plinz C. Glucosamine: Production and applications. Mar. Sci. Tech. Bull. 2026;:157–171.

MLA

Kadak, Ali Eslem, et al. “Glucosamine: Production and Applications”. Marine Science and Technology Bulletin, no. Advanced Online Publication, June 2026, pp. 157-71, doi:10.33714/masteb.1907073.

Vancouver

1.Ali Eslem Kadak, Aygül Küçükgülmez, Mehmet Çelik, Claudia Plinz. Glucosamine: Production and applications. Mar. Sci. Tech. Bull. 2026 Jun. 1;(Advanced Online Publication):157-71. doi:10.33714/masteb.1907073