Effects of Autologous Platelet-Rich Plasma on Endometrium Thickness and Pregnancy Rates During Intrauterine Insemination

Year 2019, , 63 - 66, 28.08.2019

Mehmet Sipahi

https://doi.org/10.19127/mbsjohs.544429

Cited By: 2

Abstract

Objective: Evaluation of the effect of platelet-rich plasma (PRP)
on the endometrium and pregnancy outcomes in patients undergoing insemination
due to unexplained infertility.

Methods: 24 patients who were admitted to the clinic due to
unexplained infertility, analyzed retrospectively between March 2018 and
October 2018. Gonadotropin induction was initiated on day 3 of the cycle for
follicular growth. Human chorionic gonadotropin (hCG) was applied for ovulation
induction at the point that at least 1 follicle that is over 16 mm was detected
by transvaginal ultrasound. 17.5 ml of
blood from the patient's venous system was drawn for the preparation of the PRP
which includes 4-5 times more platelets than regular blood. PRP was
administered to 12 patients (Group 1) on the hCG day, while hCG was solely
administered to the other group (Group 2) and both groups were inseminated 36
hours later.

Results: The demographic properties of all patients were
determined as follows: mean age; 29.13 years old (±3.4), mean infertility
period; 1.96 years (±1.08), mean ovulation induction period; 7.92 days (±1.76),
mean antral follicle count; 14.54 (±6.56), mean dominant follicle count; 2.04
(±0.75). Although there was no significant difference between the groups in
terms of clinical pregnancy (3/12 vs 2/12, p: 0.623), the change in endometrial
thickness was significantly higher in the PRP administered group (1.95 mm vs
0.44 mm, p< 0.001).

Conclusion: PRP application before the insemination seems promising for the
preparation of the endometrium in patients having an inadequate endometrial thickness
or in patients experiencing recurrent implantation failure.

Keywords

intrauterine insemination, endometrial thickness, autologous platelet-rich plasma, infertility, pregnancy rate

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