The Relationship Among Helicobacter pylori Positivity, Acute Phase Reactants, Blood Groups and Tumor Markers in Urea Breathe Test

Year 2017, Volume: 3 Issue: 2, 13 - 19, 28.08.2017

Ali Şenkaynağı , Mustafa Yıldız

https://doi.org/10.19127/mbsjohs.307150

Abstract

Objective: In this study, positivity of Helicobacter pylori which is very common
health problem for human, was examined by C 14 urine breath test and in this
group also blood samples, acute phase reactants, tumor markers were examined
for the specific correlation

Methods: Blood samples of 130 patients which was examined
by C 14 urine breath test, were drawn. In order to perform the urea breath
test, which was the basis of our study, the patient was starved for at least 6
hours before the test and did not use antibiotics 1 month before and active acid
inhibitors 1 week before. Following a 6-hour hunger period, 37 kBg of 14 C-urea
capsules 50 mL water were given. Breath samples were collected at 10 minutes
with a dry cartridge system (BREATHCARD). 
In this group also blood samples, acute phase reactants (crp, aso,
sedim, rf), tumor markers (CEA, CA 19-9, CA 15-3) were examined for the
specific correlation.

Results: Test results for 57 of 130 patients were found
to be positive (43.84%) while it was found to be negative (56.16%) in 73
patients. Reference ranges for blood parameters were 13.6-17.2 for HGB,
39.5-50.3 for HCT, 5.2-12.4 for WBC, 0-200 for ASO, 3.02 for CRP, 0-15 for RF,
0-3 for CEA, 0-35 for CA 19-9, 0-31.3 for CA 15-3 The mean age of patients with
negative H. pylori infection was 39.41 and the positive was 39.03. 35 of the 57
H. pylori positive patients in the
total 130 patients were female (61.4%), 22 were male (38.6%); Of 73 negative
patients, 44 were female (60.3%) and 29 were male (39.7%). There was no
sex-related collagen of H. pylori. 22
persons (38.6%) of the positive H. pylori
blood group were found in the blood group A, 9 (15.8%) were in the blood group
B, 11 (19.3%) were in the group AB and 15 (26.3%) were in the group O. It was
observed that 21 patients (28.8%) in negatives of H. pylori were blood group A, 17 patients (23.3%) were blood group
B, 14 patients (19.2%) were blood group AB and 21 patients (28.8%) were group
O.  No significant difference was
observed between blood groups and H.
pylori infection with Rh factor, and no linkage was detected.

Conclusion: As a result, there were
no significant correlation were found between acute phase reactants, tumor
markers and ABO/ Rh blood groups for H.
pylori positives.

Keywords

H. pylori, C-14 urea breath test, tumor markers, acute phase reactants, blood groups

References

• Allahverdi, T, Sülü, B. Same Day Upper and Lower Endoscopy Results in Patients Presenting with Nonspecific Abdominal Pain, Middle Black Sea Journal of Health Science 2015, 10(1):9-12