Demodex spp Distribution in Patients with Alcohol Abuse

Year 2019, Volume: 5 Issue: 3, 246 - 251, 31.12.2019

Serpil Şener , Ulku Karaman , Nihal Altunışık , Gülbahar Saraç , Hatice Cumurcu Gülden Hakverdi

https://doi.org/10.19127/mbsjohs.655707

Abstract

Objective: Demodex is an ectoparasite that can infest the human body. The infestation
can progress rapidly when the immune system is suppressed. The condition has
also been reported to be more common in subjects with alcohol abuse because of
the associated immune system abnormalities and decreased hygiene. Our aim in
this study was to determine whether a relationship was present between Demodex
spp. infestation and alcohol abuse

Methods: A total of 26 patients diagnosed
with alcohol abuse according to DSM-5 at the psychiatry outpatient department
and 24 age- and gender-matched healthy volunteers who met the study inclusion
criteria were included in the study. A standard superficial skin biopsy (SSSB)
was used in the diagnosis of Demodex folliculorum. The compliance of the
numeric variables with the normal distribution was investigated with the
Shapiro-Wilk test. The data were presented as mean, standard deviation and
percentages

Results. A significant relationship
was found between Demodex presence and alcohol abuse (p=0.001). The
relationship was also significant when patients with both alcohol abuse and
smoking were investigated (p<0.001).

Conclusion: The
Demodex spp. infestation incidence may be increased in patients with alcohol
abuse. We recommend providing the relevant treatment especially for
erythematous and itchy facial lesions in these patients as Demodex spp. can be
opportunistic pathogens.

Keywords

Demodex, Alcohol abuse, smoking, addiction and demodex

References

• Akdeniz S, Bahceci M, AK Tuzcu, Harman M, Alp S, Bahceci S. İs demodex folliculorum larger in diabetic patients?. J Europ Acad Dermatol Venereol 2002;16 (5): 539.
• Akilov OE, Mumcuoglu KY. İmmune response in demodicidosis. J Eur Acad Dermatol Venereol 2004;18:440-4.
• Aquilina C, Viraben R, Sire S. Ivermectin-responsive Demodex infestation during human immunodeficiency virus infection. Dermatology 2002 205:394-7.
• Aycan O, Otlu H, Karaman U, Daldal N, Atambay M. Frequency of Demodicosis in Various Patient and Age Groups. Turkish Society for Parasitology. 2007;31:1158.
• Bastemir S, Ermertcan A, Nese N, Aydogdu İ, Yereli K, Ozbilgin A. Hodgkin Lenfomali Bir Hastada Demodex folliculorum Enfestasyonu: Bir Olgu Sunumu. Turk Mikrobiyol Cem Derg 2015; 45(3):149-152
• Chovatiya RJ, Colegio OR. Demodicosis in renal transplant recipients. Am J Transplant 2016;16:712-6.
• Ciftci IH, Dundar U, Cetinkaya Z, Kulas M, Kiyildi N, Turel A, et al. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitol 2007;52: 70-3
• Crews FT, Bechara R, Brown LA, Guidot DM, Mandrekar P, Oak S et al. Cytokines and alcohol. Alcohol Clin Exp Res. 2006;30:720–30.
• Crews FT, Bechara R, Brown LA, Guidot DM, Mandrekar P, Oak S et al. Cytokines and alcohol. Alcohol Clin Exp Res. 2006;30:720–30.
• Demirdag HG, Ozcan H, Gursoy S. The effects of sebum configuration on Demodex spp. density. Turk J Med Sci 2016; 46: 1-7
• Durmaz S, Yula E, Aycan Kaya O, Aksoy Gokmen A, Kilinc C, Atambay M, et al. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behcet’s disease. Biomed Res 2015; 26: 549-55.
• Duzgun OY, Aytekin S. Comparison of Demodex folliculorum density in haemodialysis patients with a control group. J Eur Acad Dermatol Venereol 2007;21: 480-3.
• Erbagci Z, Ozgoztasi O. The significance of Demodex folliculorum density in rosacea. İnternational Journal of Dermatology 1998;37(6):421-5.
• Inci M, Kaya OA, Inci M, Yula E, Gokce H, Rifaioglu MM, Demirtas O, Yengil E. İnvestigating Demodex folliculorum in patients with urological cancer. Turkish Society for Parasitology.2012; 36:208-10
• Jansen T, Kastner U, Kreuter A, Altmeyer P. Rosacea-like demodicidosis associated with acquired immunodeficiency syndrome. Br J Dermatol 2001; 144: 139-42.
• Karaman U, Koloren Z, Enginyurt O, Colak C. Prevalence of demodex ectoparasites among humans in Ordu province in Turkey. Southeast Asian J Trop Med Public Health. 2016;47(2):207-13.
• Karaman U, Koloren Z, Enginyurt O, Ozer A. The Epidemiology of Demodex mites at the College Students Living in Dormitories in the City of Ordu. Turkiye Parazitol Derg 2014; 38: 166-71.
• Karincaoglu Y, Esrefoglu Seyhan M, Bayram N, Aycan O, Taskapan H. Incidence of Demodex folliculorum in patients with end stage chronic renal failure. Ren Fail 2005; 27: 495-9.
• Kockaya MH, Kaya OA, Copoglu US, Elmacioglu S. Prevalence of Demodex spp among alcohol-dependent patients. Cukurova Med J 2016;41(2):259-263.
• Marks R, Dawber RPR. Skin surface biopsy: an improved technique for the examination of the horny layer. British journal of Dermatology 1971;84(2):117-23
• Ozcelik S, Sumer Z, Degerli S, Ozyazici G, Hayta SB, Akyol M et al. The incidence of Demodex folliculorum in patients with chronic kidney deficiency. Turkish Society for Parasitology. 2007;31:66-8.
• Romeo J, Warnberg J, Nova E, Diaz LE, GonzalezGross M, Marcos A. Changes in the immune system after moderate beer consumption. Ann Nutr Metab. 2007;51:359–66.
• Rufli T, Mumcuoglu Y, Cajacob A, Buchner S: D. folliculorum: aetiopathogenesis and therapy of rosacea and perioral dermatitis (author’s transl). Dermatologica 1981;162:12-26.
• Tas Cengiz, Z., Yilmaz H., Akdeniz, N., Cicek, M., Ozkol, H ve Calka, O. Associated of demodicosis with acne rosacea. Pakistan Journal of Medical Science 2010;26(3), 640-643.
• Tilki E, Zeytun E, Dogan S. Prevalence and Density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Erzincan Province. Turkish Society for Parasitology.2017; 41: 80-6
• Turan N, Kapicioglu Y, Sarac G. The Effect of Skin Sebum Sebum, pH, and Moisture on Demodex İnfestation in Acne Vulgaris and Rosacea Patients. Turkiye Parazitol Derg.2017;41(3):143-147.
• Wang Y, Hu Q: Investigation on the prevalence of human demodex among 2248 medical students in inner Mongolia. Zhongguo Ji Sheng Chong Xue Yu ji Sheng Chong Bing Za Zhi 2001;19:239-40.
• Yun CH, Yun JH, Baek JO, Roh JY, Lee JR. Demodex Mite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns. Ann Dermatol. 2017 ;29(2):137-142.
• Zeytun E, Olmez H. Demodex (Acari: Demodicidae) Infestation in Patients with KOAH, and the Association with Immunosuppression. Erzincan University Journal of Science and Technology. 2017;10(2), 220-231.