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Year 2021, Volume: 7 Issue: 2, 164 - 167, 31.08.2021
https://doi.org/10.19127/mbsjohs.933383

Abstract

Supporting Institution

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Project Number

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Thanks

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References

  • 1. Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M. Prediabetes: a high risk state for diabetes development. The Lancet 2012;379(9833):2279‐90.
  • 2. Yenigun M. All Aspects of Diabetes Mellitus. Second Edition. İstanbul: Nobel Medical Bookstore; 2001. p:51-243.
  • 3. Baflaran S, Guzel R, Benlidayı IC, Uysal F. Osteoporozda vitamin D duzeyinin yasam kalitesi uzerine etkisi. Osteoporoz Dunyasından 2006;12(2):35-8.
  • 4. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M. Glycemic control and alveolar bone loss progression in type 2 diabetes. Ann Periodontol 1998;3:30-9.
  • 5. Ye WZ, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur J Endocrinol 2001;145:181-6. 6. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. Am J Clin Nutr 2004;79:820-5.
  • 7. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995;380:1239-45.
  • 8. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutrition Research Reviews 2009;22;82–92.
  • 9. Ozfirat Z. Chowdhury TA. Vitamin D deficiency and type 2 diabetes. Postgrad Med J 2010;86:18‐25.
  • 10. Knekt P, Laaksonen M, Mattila C, et al. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology 2008;19:666–71.
  • 11. Shankar A, Sabanayagam C, Kalıdındı S. Serum 25-Hydroxyvitamin D Levels and Prediabetes Among Subjects Free of Diabetes. Diabetes Care 2011;34:1114–19.
  • 12. Modi KD, Ahmed MI, Chandwani R, Hari Kumar KVS. Prevalance of vitamin D deficiency across the spectrum of glucoseintolerance. Journal of Diabetes & Metabolic Disorder 2015;14:54.
  • 13. Targher G, Bertolini L, Padovani R. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol 2006;65:593-97.
  • 14. Giorelli GDV, Matos LND, Saado A, Soibelman VL, Dias CD. No association between 25‐ hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross‐ sectional study. Sao Paulo Med J 2015;133(2):73‐7.
  • 15. Baynes KC, Boucher BJ, Feskens EJ, Kromhout D.Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 1997;40:344-47.
  • 16. Davidson MB, Duran P, Lee ML, Frıedman TC. High Dose Vitamin D Supplementation in People with Prediabetes and Hypovitaminosis D. Diabetes Care 2013;36:260–6.

Evaluation of Vitamin D levels of Patients with Type 2 Diabetes Mellitus Taking Oral Antidiabetic Drugs

Year 2021, Volume: 7 Issue: 2, 164 - 167, 31.08.2021
https://doi.org/10.19127/mbsjohs.933383

Abstract

Objective: The aim of this study was to evaluate the vitamin D levels of type 2 diabetes Mellitus (T2DM) patients taking oral antidiabetic drugs.

Methods: The data of 276 T2DM patients who applied to the internal medicine outpatient clinic of our hospital between January-2020 and March-2021, and the control group consisting of normoglycemic individuals in the same age group, as well as the data of 130 patients, were retrospectively reviewed from archive records. Patients with serum 25-hydroxyvitamin D (25(OH)D) level below 30 ng/mL were accepted as vitamin D deficiency and insufficiency, and patients with serum 25(OH)D levels above 30 ng/mL were accepted as normal vitamin D adequacy. The data of T2DM patients taking oral antidiabetic drugs and the data of normoglycemic control group patients were statistically compared.

Results: 60.8% (n=168) of T2DM patients taking 276 oral antidiabetic drugs included in the study were female and 39.2% (n=108) were male. The mean age of the patients was 52.5±4.2 years. The mean serum 25(OH)D level of the T2DM group patients taking oral antidiabetic drugs was 9.6±4.3 ng/mL. Of the 130 patients taken as the normoglycemic control group, 65.3% (n=85) were female and 34.7% (n=45) were male. The mean age of these patients was 53.6±4.4 years. Mean serum 25(OH)D level of the control group was 16.1±4.6 ng/mL. When the 25(OH)D levels, HOMA-IR, fasting blood glucose, HbA1c and BMI ratios of the T2DM group patients taking oral antidiabetic drugs were compared statistically compared to the normoglycemic control group patients, significant differences were found between the groups (respectively; p <0.01; p < 0.01; p <0.01; p <0.01; p <0.01).

Conclusion: The fact that vitamin D levels were found to be significantly lower in T2DM patients taking oral antidiabetic drugs compared to the normoglycemic control group suggests that vitamin D deficiency has an important place in the formation of T2DM. We think that early vitamin D replacement therapy in these patients may be a preventive factor in the formation of T2DM.

Project Number

yok

References

  • 1. Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M. Prediabetes: a high risk state for diabetes development. The Lancet 2012;379(9833):2279‐90.
  • 2. Yenigun M. All Aspects of Diabetes Mellitus. Second Edition. İstanbul: Nobel Medical Bookstore; 2001. p:51-243.
  • 3. Baflaran S, Guzel R, Benlidayı IC, Uysal F. Osteoporozda vitamin D duzeyinin yasam kalitesi uzerine etkisi. Osteoporoz Dunyasından 2006;12(2):35-8.
  • 4. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M. Glycemic control and alveolar bone loss progression in type 2 diabetes. Ann Periodontol 1998;3:30-9.
  • 5. Ye WZ, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur J Endocrinol 2001;145:181-6. 6. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. Am J Clin Nutr 2004;79:820-5.
  • 7. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995;380:1239-45.
  • 8. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutrition Research Reviews 2009;22;82–92.
  • 9. Ozfirat Z. Chowdhury TA. Vitamin D deficiency and type 2 diabetes. Postgrad Med J 2010;86:18‐25.
  • 10. Knekt P, Laaksonen M, Mattila C, et al. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology 2008;19:666–71.
  • 11. Shankar A, Sabanayagam C, Kalıdındı S. Serum 25-Hydroxyvitamin D Levels and Prediabetes Among Subjects Free of Diabetes. Diabetes Care 2011;34:1114–19.
  • 12. Modi KD, Ahmed MI, Chandwani R, Hari Kumar KVS. Prevalance of vitamin D deficiency across the spectrum of glucoseintolerance. Journal of Diabetes & Metabolic Disorder 2015;14:54.
  • 13. Targher G, Bertolini L, Padovani R. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol 2006;65:593-97.
  • 14. Giorelli GDV, Matos LND, Saado A, Soibelman VL, Dias CD. No association between 25‐ hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross‐ sectional study. Sao Paulo Med J 2015;133(2):73‐7.
  • 15. Baynes KC, Boucher BJ, Feskens EJ, Kromhout D.Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 1997;40:344-47.
  • 16. Davidson MB, Duran P, Lee ML, Frıedman TC. High Dose Vitamin D Supplementation in People with Prediabetes and Hypovitaminosis D. Diabetes Care 2013;36:260–6.
There are 15 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research articles
Authors

Harun Düğeroğlu 0000-0002-0546-175X

Project Number yok
Publication Date August 31, 2021
Published in Issue Year 2021 Volume: 7 Issue: 2

Cite

Vancouver Düğeroğlu H. Evaluation of Vitamin D levels of Patients with Type 2 Diabetes Mellitus Taking Oral Antidiabetic Drugs. Mid Blac Sea J Health Sci. 2021;7(2):164-7.

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