Transrektal prostat biyopsisi cinsel işlev bozukluğuna neden olur mu? 252 hastanın kesitsel değerlendirmesi

Year 2022, Volume: 8 Issue: 4, 515 - 524, 30.11.2022

Mevlüt Keleş Mustafa Aydın Lokman İrkilata Alper Bitkin Ebubekir Akgüneş Mustafa Kemal Atilla

https://doi.org/10.19127/mbsjohs.1110819

Abstract

Keywords

Erektil Disfonksiyon, Prostat, Prostat Spasifik Antijen, Biyopsi

Thanks

İstatistiksel analizler için sağladığı değerli katkılarından dolayı Dr. Hasan Durmuş'a teşekkür ederiz.

Does transrectal prostate biopsy cause sexual dysfunction? Cross-sectional evaluation of 252 patients

Abstract

Objective: In this study, we aimed to evaluate whether there are negative effects of transrectal prostate biopsy (TPB) on sexual functions (SF).
Methods: This study includes 252 male patients evaluated prospectively who underwent TPB in our clin-ic between January 2015 and September 2016. Patients with chronic diseases (e.g. diabetes mellitus, hy-pertension) and the use of drugs (e.g. antihypertensive drugs, antidepressants) that can affect SF were excluded. Patients completed the IIEF-15 forms before TPB, in the first, third, and sixth months after TPB. Patients were evaluated in terms of erectile function (EF), orgasmic functions (OF), sexual desire (SD), intercourse satisfaction (IS), and overall sexual satisfaction (OSS).
Results: The relationship between follow-up time and EF, OF, SD, IS and OSS scores were analyzed. A significant difference was observed in EF scores before TPB and in the first month after TPB (p=0,007). However, in subgroup analyses, it was determined that this significant difference was only in the PCa patients. In BPH-diagnosed patients, there was no significant difference between the ED score and the follow-up times. OF, IS, and OOS scores in the 1st, 3rd, and 6th months decreased significantly according to the initial score (p = 0,001). SD scores showed no significant differences among follow-ups (p=0,191).
Conclusion: Erectile dysfunction (ED) is not likely for all patients who undergo TPB. Our study revealed that PCa patients are short-term sufferers of ED after TPB. But, according to our data, it is not clear whether the cause is TPB or anxiety due to PCa diagnosis.

Keywords

Erectile Dysfunction, Prostate, Prostate-Specific Antigen, Biopsy

References

• 1. Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, et al. EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent—update 2013. Europe-an urology. 2014;65(1):124-37.
• 2. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impo-tence. Jama. 1993;270(1):83-90.
• 3. Zisman A, Leibovici D, Kleinmann J, Siegel Yi, Lindner A. The impact of prostate biop-sy on patient well-being: a prospective study of pain, anxiety and erectile dysfunction. The Journal of urology. 2001;165(2):445-54.
• 4. Zisman A, Leibovici D, Kleinmann J, Cooper A, Siegel Y, Lindner A. The impact of prostate biopsy on patient well-being: a prospective study of voiding impairment. The Journal of urology. 2001;166(6):2242-6.
• 5. Chrisofos M, Papatsoris A, Dellis A, Varkarakis I, Skolarikos A, Deliveliotis C. Can prostate biopsies affect erectile func-tion? Andrologia. 2006;38(3):79-83.
• 6. Aktoz T, Kaplan M, Turan U, Memis D, Atakan I, Inci O. ‘Multimodal’approach to the management of prostate biopsy pain and effects on sexual function: efficacy of levo-bupivacaine adjuvant to diclofenac sodium–a prospective randomized trial. Andrologia. 2010;42(1):35-40.
• 7. Murray KS, Bailey J, Zuk K, Lopez‐Corona E, Thrasher JB. A prospective study of erec-tile function after transrectal ultrasonogra-phy‐guided prostate biopsy. BJU interna-tional. 2015;116(2):190-5.
• 8. Linden-Castro E, Pelayo-Nieto M, Espinosa-Perezgrovas D, Rubio-Arellano E, Catalán-Quinto G, Guzmán-Hernández F, et al. The impact of transrectal prostate biopsy on erectile function. Actas Urológicas Espa-ñolas (English Edition). 2016;40(7):453-6.
• 9. Klein T, Palisaar RJ, Holz A, Brock M, Noldus J, Hinkel A. The impact of prostate biopsy and periprostatic nerve block on erectile and voiding function: a prospective study. The Journal of urology. 2010;184(4):1447-52.
• 10. Fujita K, Landis P, McNeil BK, Pavlo-vich CP. Serial prostate biopsies are associ-ated with an increased risk of erectile dys-function in men with prostate cancer on ac-tive surveillance. The Journal of urology. 2009;182(6):2664-9.
• 11. Hilton JF, Blaschko SD, Whitson JM, Cowan JE, Carroll PR. The impact of serial prostate biopsies on sexual function in men on active surveillance for prostate cancer. The Journal of urology. 2012;188(4):1252-9.
• 12. Braun K, Ahallal Y, Sjoberg DD, Ghoneim T, Esteban MD, Mulhall J, et al. Effect of repeated prostate biopsies on erec-tile function in men on active surveillance for prostate cancer. The Journal of urology. 2014;191(3):744-9.
• 13. Dale W, Bilir P, Han M, Meltzer D. The role of anxiety in prostate carcinoma: a structured review of the literature. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2005;104(3):467-78.
• 14. Macefield R, Metcalfe C, Lane J, Do-novan J, Avery K, Blazeby J, et al. Impact of prostate cancer testing: an evaluation of the emotional consequences of a negative biop-sy result. British journal of cancer. 2010;102(9):1335-40.
• 15. Mehnert A, Lehmann C, Graefen M, Huland H, Koch U. Depression, anxiety, post‐traumatic stress disorder and health‐related quality of life and its association with social support in ambulatory prostate cancer patients. European journal of cancer care. 2010;19(6):736-45.
• 16. Sharpley CF, Christie DR, Bitsika V. Variability in anxiety and depression over time following diagnosis in patients with prostate cancer. Journal of psychosocial on-cology. 2010;28(6):644-65.
• 17. Brindle LA, Oliver SE, Dedman D, Do-novan JL, Neal DE, Hamdy FC, et al. Meas-uring the psychosocial impact of popula-tion‐based prostate‐specific antigen testing for prostate cancer in the UK. BJU interna-tional. 2006;98(4):777-82.
• 18. Turgut, H., Sarıer, M., Öztorun, K. Yalçın K, Özgür G. Evaluation of Sexual Function According to the Size of the Needle Used in Transrectal-Ultrasonography-Guided Pros-tate Biopsy. Bull Urooncol, 2021;20(3), 138-141.