The Impact of Carbon Monoxide İntoxication on Thiol/Disulfide Hemostasis

Year 2023, Volume: 9 Issue: 3, 480 - 488, 31.08.2023

Özge Ebru Dağcı Varhan , Gülşah Çıkrıkçı Işık , Mustafa Ekici , Tuba Şafak , Şeref Kerem Çorbacıoğlu , Yunsur Çevik

https://doi.org/10.19127/mbsjohs.1280857

Abstract

Objective: Carbon monoxide (CO) poisoning is an oxidative stress factor. The aim of the study is to evaluate impact of CO intoxication on thiol/disulfide homeostasis (TDH), an important antioxidative system of the body.
Methods: This is a prospective study included 84 participants in each group. Blood samples were taken two time in study group (CO intoxication group), before and at the end of the 3rd hour of normobaric oxygen therapy and once in the control group. TDH parameters were studied with an automated assay developed by Erel et al. Statistical analysis done with SPSS program.
Results: Among thiol/disulfide homeostasis parameters, in study group native (sh) and total thiol (tt) levels in samples taken at the beginning of the oxygen treatment were significantly higher than sh and tt levels of the control group [Study group sh: 399.70 μmoll−1 (354.50-423.65), tt: 439.1 μmoll−1 (390.9-467.3) and control group sh: 362.95 μmoll−1 (321.95-401.25), tt: 396.1 μmoll−1 (358.5-435), p=0.01 and p<0.001 respectively]. There was no difference between the groups in term of other TDH parameters. TDH parameters were measured after 3-hour normobaric oxygen treatment, and it was shown sh and tt levels were significantly reduced after treatment.
Conclusion: Our study demonstrated that among TDH parameters native and total thiol levels were increasing in patients with CO poisoning and those levels were decreasing in time during normobaric oxygen treatment.

Keywords

carbon monoxide intoxication, Thiol/disulfide homeostasis, oxidative stress, antioxidant systems

Supporting Institution

No supporting instutition

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