Diltiazem Added Blood Cardioplegia And Myocardial Protection

Year 2000, Volume: 1 Issue: 2, 23 - 28, 01.08.2000

Bülent Çümen Berent Dişçigil M. İsmail Badak Uğur Gürcün Mehmet Boğa Erdem Özkısacık Mustafa Özbaran Suat Buket Önol Bilkay

Abstract

Objective: The aim of this prospective study was to demonstrate the effect of diltiazem, a calcium channel blocker, as an additive to cardioplegic solution in myocardial protection. Methods: Thirty patients who underwent coronary artery bypass grafting on an elective basis were divided into two groups: control group and diltiazem group (n=15, each). Diltiazem was added to the blood cardioplegic solution in the diltiazem group. Mean age was 56.8+10.11 years in the control group and 60.20+10.44 in the diltiazem group. There was no difference in the extent of coronary artery disease, cross-clamp time, cardiopulmo-nary bypass (CPB) time between the two groups. Cardioplegic solution was delivered antegradely. Hemodynam-ics and blood enzyme levels were measured before and following CPB. Results: In the diltiazem group, cardiac output and cardiac index was found to be lower in postoperative 1 st and 6th hours (p<0.05). However, there was no difference in stroke volume index and left ventricular stroke work index values. Blood creatine kinase MB (CK-MB) isoenzyme levels were found to be lower in the diltiazem group in 6th, 12th, and 24th hours postoperatively (p<0.05). Patient hemodynamics did not differ clinically in either group. Conclusion: These results demonstrate the beneficial effects of diltiazem addition to blood cardioplegic solution on myocardial protection as evidenced by lower levels of CK-MB in the postoperative period.

Keywords

Diltiazem, cardioplegia, myocardial protection

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