MANYETİK REZONANS GÖRÜNTÜLEME YAPILACAK ÇOCUKLARDA PROPOFOL İLE MİDAZOLAM + PROPOFOL SEDASYONUNUN KARŞILAŞTIRILMASI

Year 2002, Volume: 3 Issue: 1, 13 - 17, 01.04.2002

Nil Kurt Özcan Ertürk Hülya Oral

Abstract

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Keywords

Manyetik rezonans görüntüleme, sedasyon, mental retardasyon, epilepsi, pediatrik

Comparison of Propofol and Midazolam Plus Propofol Sedation for Magnetic Resonance İmaging in Children

Abstract

Background and objective: The aim of this investigation was to study the effects of propofol and midazolam followed by propofol on children who had epilepsy and mental retardation, and could not be sufficiently sedated with orally administered chloral hydrate and cardiac cocktail for Magnetic Resonance Imaging. Methods: We have compared the sedation levels using the Ramsay Sedation Score maintained by the infusion of either propofol alone or followed by intramuscular administration of midazolam in 23 neurologically debilitated children aged 4-10 years undergoing Magnetic Resonance Imaging. The patients received a slow intravenous bolus injectionof2 mgkg-1 propofol followed by continuous infusion, with(n=11) orwithout (n=12) midazolam (0.2 mg kg-1) sedation given intramuscularly 15 minutes before the Magnetic Resonance Imaging._Mann Whitney U, Chi square and Fisher's exact tests were used for the statistical analysis testing, p< 0.05 were considered to have statistical significance. Results: Sedation level was higher in midazolam plus propofol group than propofol group immediately before intravenous cannulation, and during Magnetic Resonance Imaging (p = 0.002; p = 0.001 respectively). In both groups, the respiratory rate decreased significantly following the injection of propofol (p= 0.025 and p= 0.021). Patients in the propofol group recovered rapidly. At the end of the first hour, the recovery scores of both groups were similar. In the dose scheme we have used, propofol produced sedation during Magnetic Resonance Imaging. Conclusions: In mentally retarded children, intramuscular midazolam injection followed by propofol resulted in better cooperation and sedation.

Keywords

Magnetic resonance imaging (MRI), sedation, mental retardation, epileptic, children

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