KEMİĞİN PAGET HASTALIĞI; Bir olgu ve literatürün gözden geçirilmesi

Year 2002, Volume: 3 Issue: 1, 25 - 27, 01.04.2002

Taşkın Şentürk Nihat Özgel Hulki Meltem Sönmez

Abstract

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Keywords

Paget hastalığı, kemik semptomları

Paget's Disease of Bone; A Case Report and Review of the Literature

Abstract

Paget's disease of bone is a common condition characterized by bone pain, deformity, pathological fracture,
neurologic disorders and an increased incidence of osteosarcoma in the elderly people. Genetic factors play a role
in the pathogenesis of Paget's disease but the molecular basis of the disease remains unclear. Histopathologically
the disease is characterized by markedly increased osteoclast formation and bone resorption followed by
excessive new bone formation.
Frequently the diagnosis is made as an incidental finding on X-ray, or it is considered because of an unexpected
elevation in serum alkaline phosphatase. Paget's disease can reduce both function and mobility, and can be
associated with psychological problems. Therefore, quality of life may be reduced in patients with Paget's
disease.
We report a patient with Paget's disease and discuss features of this disorder which is of importance in the elderly
population

Keywords

Paget's disease, bone symptoms

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