Current Inspect To Pain And Pain Mechanism

Year 2002, Volume: 3 Issue: 2, 37 - 48, 01.08.2002

Osman Nuri Aydın

Abstract

Chemical, mechanical, orthermalstimuli leadto autonomic (changes inheartrate orbloodpressure) or hormonal (adrenal and pituitary secretion) responses well as causing subjective sensation of pain by tissue destruction and disruption of vasculature integrity. A better understanding of pain physiopathology and pain pathways helps us in treatment of pain. Recent advances in our understanding of the chemical and physiologic pain mechanisms have provided us with important developments in pain therapy. In this article, current information about the definition and classification of pain and its chemical and physiologic mechanisms are reviewed.

Keywords

Pain pathways, pain perception, cerebral cortex, nociception, neurotransmitters

References

• 1. Yücel A. Akut aðrý nörofizyolojisi. Hasta kontrollü analjezi (PCA). Ýstanbul: MER Matbaacýlýk& Yayýncýlýk, 1997: 5-19.
• 2. Morgan GE, Mikhail MG. Pain Management. In: Clinical Anesthesiology, 2 ed. New Jersey: PrentticeHall Interntional, Inc., 1996: 274-316.
• 3. Merskey HM, Pain terms. 1986; suppl. 3: 215-21.
• 4. Kayhan Z. Klinik Anestezi. 2. Baský Ýstanbul: Logos Yayýncýlýk, 1997: 759-87.
• 5. Ertekin C. Aðrýnýn nöroanatomisi ve nörofizyolojisi. Aðrý ve tedavisi. Ýbrahim Yegül (ed). Ýzmir:Yapým Matbaacýlýk, 1993: 1-18.
• 6. Raj PP. Aðrý taksonomisi. Erdine S (ed). Aðrý, Birinci baský, Ýstanbul;Alemdar Ofset, 2000: 12-20.
• 7. Türkoðlu M. Aðrýnýn tanýmlanmasý ve ölçümü. Aðrý ve tedavisi. Ýbrahim Yegül (ed). Ýzmir:Yapým Matbaacýlýk, 1993: 19-99.
• 8. Bonica JJ. The Management of Pain, 2 ed. Philadelphia: Lea & Febriger 1990.
• 9. Benjamin WJ. Pain Mechanisms: Anatomy, Physiology and Neurochemistry. In: Raj PP (ed). Practical Management of Pain, 3 ed., Missouri: Mosby Inc., 2000: 117-45.
• 10. Aldemir T. Aðrý sendromlarý. Erdine S (ed). Aðrý, birinci baský, Ýstanbul;Alemdar Ofset, 2000: 714-63.
• 11. Merskey HM, Bogduk N, Classification of Chronic Pain, 2 ed., Seattle: IASP Press, 1994: 211-8.
• 12. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993; 54: 241-89.
• 3. Ness TJ and Gebhart GF. Visceral pain: a review of experimental studies. Pain 1990; 41: 167-234.
• 14. Cervero F. Sensory innervation of the viscera: peripherals basis of visceral pain. Physiol Rev. 1994; 74: 95-138.
• 15. Dray A and Perkins MN. Bradykinin and inflammatory pain, trends. Pharmacol Sci 1993; 16: 99-104.
• 16. Sorkin LS. Basic pharmacology and physiology of acute pain proccessing. In: Wallace MS, Dunn JS, Yaksh TL (eds). Anesthesiology Clinics of North America. Philadelphia: W.B. Saunders Company, 1997: 235-50.
• 17. Schouenborg J, Sjolund B. First-order nociceptive synapses in rat are blocked by an amino acid antagonist. Brain Res 1986; 376: 394-8.
• 18. Sorkin L, McAdoo DJ. Amino acids and serotonin are released into the lumbar spinal cord of the anesthesized cat following intradermal capsaicin injections. Brain Res 1993; 607: 89-98.
• 19. Childs A, Evans R, Watkins J: The pharmacological selectivity of three NMDA antagonists. Eur J Pharmacol 1988; 145: 81-6.
• 20. Salt T, Hilkl R. Pharmacological differentiation between responsesif rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimulation. Brain Res 1983; 262: 167-71.
• 21. Aanonsen L, Wilcox GL. Nociceptive action of exicitatory amino acids in the mouse: effects of spinally administered opioids, phencycladine and sigma agonists. J Pharmacol Exp Ther 1987; 243: 9-19.
• 22. Raigorodsky G, Urca G. Intrathecal N-methyl-Daspartate(NMDA) activates both nociceptive and antinociceptive pathways. Brain Res 1987; 422: 158- 62.
• 23. O'Brien C, Woolf C, F,tzgerald M, et al. Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience 1989; 493-502.
• 24. Casey KL. Pain and central nervous system disease: The central pain sendroms. Raven press, Newyork 1991.
• 25. Yaksh TL, Aimone LD. The Central pharmacology of pain transmission. In: Wall PD, Melzack R (eds). Textbook of Pain, 2 ed. Edinburg: Churchill Livingstone, 1989, 181-205.
• 26. Heavner JE, Willis WD. Pain pathways: Anatomy and physiology. In: Raj PP (ed). Practical Management of Pain, 3 ed. St Louis: Mosby Inc., 2000; 107-45.
• 27. Dickenson AH. NMDA receptor antagonits as analgesics. In: Fields HL, Liebeskind (eds), Pharmocolgical approaches to the treatment of pain. Seattle: IASP Press, 1994: 173-87.
• 28. Price DD, Mao J, Mayer DJ. Central neural mechanisms of normal and abnormal pain states. In Fields HL, Liebeskind (eds). Pharmocological approaches to the Treatment of Pain. Seattle: IASP Press, 1994: 61-84.
• 29. Erdine S. Aðrý mekanizmalarý. Erdine S (ed). Aðrý, Birinci baský, Ýstanbul;Alemdar Ofset, 2000: 20
• 30. Tedesco LS, Fuseler J, Grisham M,Wolf R, Roerig SC. Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. Pain 2002; 95: 215-23.
• 31. DrayA. Neurogenic mechanisms and neuropeptides in chronic pain. Prog Brain Res 1996; 110: 85-94.
• 32. Alcaraz MJ, Guillen MI. The nitric oxide related therapeutic phenomenon: a challenging task. Curr Pharm Des 2002; 8: 215-31.
• 33. Price DD. Psychological mechanisms of pain and analgesia. Seattle: IASP Press, 1999: 48-54.
• 34. Konietnzny F, Perl E, Trevino D, Light A, Hensel H. Sensory experiences in man evoked intraneural eletrical stimulation of intact cutaneous afferent fibers. Exp Brain Res 1981; 42: 219-22.
• 35. Valbo A. Sensations evoked from the glabreus skin of human hand by electrical stimulation of unitary mechanosensitive afferents. Brain Res 1981; 215: 359- 63.
• 36. Christensen B, Perl E. Spinal neurons spesifically excited by noxious or thermal stimuli: Marginal zone of the dorsal horn. J Neurophysiol 1970; 33; 293-307.
• 37. Craig A, Kniffki KD. Sphinothalamic lumbosacral lamina I cells reponsive to skin and muscle stimulation in the cat. J Physiol 1985; 365: 197-221.
• 38. Cervero F, Iggo A, Molony V. Supraspinal linkage of substantia gelatinosa neurones: Effect of descending impulses. Brain Res 1979; 136: 3512-355.
• 39. Gerber G, Randic M. Participation of excitatory amino acids receptors in the slow excitatory synaptic transmission in the rat spinal cord in vitro. Neurosci Lett 1989; 106: 220-8.
• 40. Urban L, Randic M. Slow excitatory transmission in rat dorsal horn: Possible mediation by peptides. Brain Res 1984; 290: 336-41.
• 41. Price D, Mao J, Frenk H, Mayor DJ. The N-methyl-Daspartate receptor antagonist dextro-methorphan selectively reduces temporal summation of second pin in man. Pain 1994; 59: 165-74.
• 42. Minami T, Nishihara I, Uda R, Ito S, Hyodo M, Hayaishi O. Involvement of glutamate receptors in allodynia induced by prostoglandins E2 and F2 alpha injected int conscious mice. Pain 1994; 57: 225-31.
• 43. Aydin ON, Erenmemisoglu A. An antinociceptive effect of the intraperitoneal administration of central acting drugs in mice.Aðrý 2000; 12: 48-9.
• 44. Malmberg A, Yaksh T. Hyperalgesia mediated by spinal glutamate or SP receptors blocked by spinal cyclooxygenase inhibition. Science 1992; 257; 1276- 9.
• 45. Radhakrishnan V, Yashpal K, Hui-Chan C, Henry JL. Implication of anitric oxide synthase mechanism in the action of substance P: L-NAME blocks the thermal hyperalgesia induced by endogenous and oxgenous substance Pin the rat. Eur J Neurosci 1995; 7: 1920-5.
• 46. Hirshberg RM, Al-Chaer ED, Lawand NB, Westlund KN, Willis WD. Is there a pathway in the posterior funiculus that signals visceral pain? 1996;67:291-305.
• 47. Hoheisel V, Koch K, Mense S, Functional reoorganization in rat dorsal horn during experimental myositis. Pain 1994; 59: 111-8.
• 48. Mense S, Hoheisel V, Kaske A, Reinert A. Muscle pain: Basic mechanisms and clinical correllates. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z (eds): Proceedings of the 8 World Congress in Pain Research and Management, Philadelphia: IASP press, 1997; 479-96.
• 49. Melzac R, Casey KL. Sensory, motivational and central control determinants of pain. In: Kenshalo DR (ed). Skin senses. New York: Springfield, IL., 1968: 423-35.
• 50. Boivie J. An anatomical reinvestigation of terminationof the spinothalamic tract in the monkey. J Comp. Neurol. 1979; 186: 343-70.
• 51. Craig AD, Reiman EM, Evans A, Bushnell MC. Functional imaging of an illusion of pain. Nature 1996; 21: 456-8 (Abstract).
• 52. Coghill RC. Brain mechanisms supporting the pain experience: A distributed processing system. In: Max M (ed). Pain 1999-An Upgrated Review (Refresher Course Syllabus). Seattle: IASP Press, 1999: 67-77.
• 53. Casey KL, Minoshima S, Morrow TJ, Koeppe RA. Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. J. Neurophysiol. 1996; 76: 571-81.
• 54. Coghii RC, Talbot JD, Meyer E, Gjedde A, Evans AC, Bushnell MC, Duncan GH. Distributed processing of pain and vibration in the human brain. J Neurosci 1994; 14: 4095-108.
• 55. Iadorola MJ, Berman KF, Zeffir TA, Byas-Smith MG, Gracely RH, Max MB, Bennet GJ. Neural activation during acute capsaicin-evoked pain and allodynia assessed with positron emission tomography. Brain 1998; 121: 931-47.
• 56. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997; 277: 968- 71.
• 57. Wall PD, The mechanisms by which tissue damage and pain are related. In Campbell JN (ed) Pain 1996-An Updated Review, Seattle: IASP Press, 1996: 123-6.
• 58. Turk D, Rudy TE. IASP taxonomy of chronic pain syndromes, preliminary assessment of reliability. Pain 1987; 177: 177-89.