KRONİK AKTİF HEPATÝT B'Lİ ÇOCUK HASTADA İNTERFERON VE LAMUVİDİN TEDAVİSİ: OLGU SUNUMU
Year 2002,
Volume: 3 Issue: 3, 35 - 37, 01.12.2002
Ferah Sönmez
Tolga Ünüvar
Gülten İnan
Münevver Türkmen
Ali Öztürk
Emel Dikicioğlu
References
- 1. Çakaloðlu Y, Ökten A. Kronik viral hepatitlerde tedavi
yaklaþýmlarý 1998Ankara Bilimsel TýpYayýnevi Sayfa:
26-51.
- 2. Pessoa MG, Wright TL. Update on clinical trials in the
treatment of hepatitis B. J Gastroenterol Hepatol
1999;14 Suppl: 6-11.
- 3. Schalm SW, Heathcote J, Cianciara J et al. Lamivudin
and alpha interferon combination treatment of patients
with chronic hepatitis B infection:a randomised trial.
Gut 2000;46: 562-8.
- 4. Farrel G. Hepatitis B antigen seroconversion effects of
lamivudine alone or in combination with interferon
alpha. J Med Virol 2000;6: 374-9.
- 5. Mutimer D, Naoumov Nhonkoop P et al. Combination
alpha-interferon and lamivudine therapy for alphainterferon-rezistant
chronic hepatitis B infection:
results of a pilot study. J.Hepatol 1998;28: 923-9.
- 6. Wong DKH, Cheung AM, O'Rourke K, et al. Effect of
alpha interferon treatment in patients with hepatitis B
antigen positive chronic hepatitis B. A meta analysis.
Ann Intern Med 1993;119: 312-323.
- 7. Wong JB, Koff RS, Tine F, Pauker SG. Costeffectiveness
of interferon-á 2b treatment for hepatitis
B e antigen-positive chronic hepatitis B. Ann Intern
Med 1995;122: 664-675.
- 8. Janssen HL, Gerken G, Carreno V et al. Interferon alfa
for chronic hepatitis B infection: increased efficacy of
prolonged treatment. The European Concerted Action
on Viral Hepatitis (EUROHEP). Hepatology 1999;30:
238-43.
- 9. Lau DT, Everhart C, Kleiner DE et al. Long-term
Follow-up of patients with chronic hepatitis B treated
with interferon alfa. Gastroenterology 1997; 113:
1660-7.
- 10. Rumi M, Romeo R, de Filippi F et al. A multicentre
randomized clinical trial of recombinant alpha-2a
interferon therapy in patients with chronic hepatitis B.
Ital J Gastroenterol 1993;2:117-20.
- 11. Dusheiko G, Lamivudine of chronic hepatitis B. Rev
Med Virol 1998 ;8: 153-159.
- 12. Dienstag Jl,Schiff ER,Wright TL et al. Lamivudine as
initial treatment for chronic hepatitis B in the United
States. N Engl J Med 1999;341: 1256-63.
- 13. Lai CL, Chien RN, Leung NW et al. A one-year trial of
lamivudine for chronic hepatitis B. Asia Hepatitis
Lamivudine Study Group. N Engl J Med 1998; 339 :
61-8.
Interferon and Lamivudine Combination Therapy in a Child with Chronic Hepatitis B: ACase Report
Year 2002,
Volume: 3 Issue: 3, 35 - 37, 01.12.2002
Ferah Sönmez
Tolga Ünüvar
Gülten İnan
Münevver Türkmen
Ali Öztürk
Emel Dikicioğlu
Abstract
As of today, there is yet no succesful treatment of chronic hepatitis B. Failure of interferon a-2a treatment for chronic viral hepatitis has prompted combination therapy. We present a 4 year old male infected with chronic hepatitis B in the replication phase who was treated with a combination of interferon a-2a and lamivudine therapy. Full remission was reached at the end of one year and this affect was still observed after one months of follow-up. So we believe that efficiency of this combination must be researched with controlled and extensive studies.
References
- 1. Çakaloðlu Y, Ökten A. Kronik viral hepatitlerde tedavi
yaklaþýmlarý 1998Ankara Bilimsel TýpYayýnevi Sayfa:
26-51.
- 2. Pessoa MG, Wright TL. Update on clinical trials in the
treatment of hepatitis B. J Gastroenterol Hepatol
1999;14 Suppl: 6-11.
- 3. Schalm SW, Heathcote J, Cianciara J et al. Lamivudin
and alpha interferon combination treatment of patients
with chronic hepatitis B infection:a randomised trial.
Gut 2000;46: 562-8.
- 4. Farrel G. Hepatitis B antigen seroconversion effects of
lamivudine alone or in combination with interferon
alpha. J Med Virol 2000;6: 374-9.
- 5. Mutimer D, Naoumov Nhonkoop P et al. Combination
alpha-interferon and lamivudine therapy for alphainterferon-rezistant
chronic hepatitis B infection:
results of a pilot study. J.Hepatol 1998;28: 923-9.
- 6. Wong DKH, Cheung AM, O'Rourke K, et al. Effect of
alpha interferon treatment in patients with hepatitis B
antigen positive chronic hepatitis B. A meta analysis.
Ann Intern Med 1993;119: 312-323.
- 7. Wong JB, Koff RS, Tine F, Pauker SG. Costeffectiveness
of interferon-á 2b treatment for hepatitis
B e antigen-positive chronic hepatitis B. Ann Intern
Med 1995;122: 664-675.
- 8. Janssen HL, Gerken G, Carreno V et al. Interferon alfa
for chronic hepatitis B infection: increased efficacy of
prolonged treatment. The European Concerted Action
on Viral Hepatitis (EUROHEP). Hepatology 1999;30:
238-43.
- 9. Lau DT, Everhart C, Kleiner DE et al. Long-term
Follow-up of patients with chronic hepatitis B treated
with interferon alfa. Gastroenterology 1997; 113:
1660-7.
- 10. Rumi M, Romeo R, de Filippi F et al. A multicentre
randomized clinical trial of recombinant alpha-2a
interferon therapy in patients with chronic hepatitis B.
Ital J Gastroenterol 1993;2:117-20.
- 11. Dusheiko G, Lamivudine of chronic hepatitis B. Rev
Med Virol 1998 ;8: 153-159.
- 12. Dienstag Jl,Schiff ER,Wright TL et al. Lamivudine as
initial treatment for chronic hepatitis B in the United
States. N Engl J Med 1999;341: 1256-63.
- 13. Lai CL, Chien RN, Leung NW et al. A one-year trial of
lamivudine for chronic hepatitis B. Asia Hepatitis
Lamivudine Study Group. N Engl J Med 1998; 339 :
61-8.