Light Microscopic Analysis of the Effects of Gd-DTPA Dimeglumine and Iopromide on Rabbit Hyaline Cartilage and Synovial Membrane

Year 2004, Volume: 5 Issue: 1, 17 - 21, 01.04.2004

Ulukan İnan Nusret Köse Cengiz Bayçu Hakan Ömeroğlu Sinan Seber

Abstract

Objective: The aim of this study is to assess the effects of contrast agents on hyaline cartilage and synovial membrane in a rabbit model. Material and Method: Light microscopic analysis of the effects of intraarticular Iopromide and Gd-DTPA on synovial membrane and hyaline cartilage at lsthour, lstday, lst weekand2nd week was performed. NaCl%0.9 was used as control. Results: Hyperemia, hemorhage and increase in the vacuolised cell number in the superficial stroma were observed in the synovial membrane. Proliferation, hypertrophy, dense glycogen storage, pycnosis and decrease in glycosaminoglycan (GAG) staining were observed in the hyaline cartilage. These effects lessened in two weeks. Conclusion: We were not able to demonstrate that contrast agents have any significant effect on hyaline cartilage and synovial membrane (p>0.05).

Keywords

X-ray contrast media, arthrography

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