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SUÇİÇEĞİ ENFEKSİYONU SONRASI GELİŞEN ASEPTİK MENENJİT VE İMMÜN TROMBOSİTOPENİK PURPURALI İKİ OLGU

Year 2005, Volume: 6 Issue: 2, 39 - 41, 01.08.2005

Abstract

Suçiçeği, Varicella Zoster virüsünün (VZV) primer enfeksiyonudur. VZV viremisine bağlı olarak iç organ vesantral sinir sistemi tutulumu gözlenebilir. Nörolojik komplikasyonlar, suçiçeği enfeksiyonu geçiren çocuklarınhastaneye en sık yatış endikasyonları arasındadır. Üstelik tipik deri döküntüsü olmadan da görülebilirler.Suçiçeğinin hemorajik komplikasyonları çocuklukta nadirdir. İmmün yetmezliklilerdebirlikte yaygın hemorajik döküntülere yol açabilir. Trombositopeni suçiçeğinigözlenebileceği gibi daha geç de ortaya çıkabilir.Bu makalede, suçiçeği enfeksiyonundan sonra gelişmiş aseptik menenjitli 7 yaşında erkek olgu ile immuntrombositopenik purpuralı (İTP) 6 yaşında erkek olgu sunulmuştur. Her iki olguda da iyileşen suçiçeğidöküntüleri vardı. Aseptik menenjitli olgu spontan iyileşirken, İTP'li olgu metil prednizolon tedavisine yanıtverdi. Bu iki olgu nedeniyle suçiçeğinin komplikasyonlu seyredebileceği ve aşı ile korunmanın önemivurgulanmıştır

References

  • Rentier B, Gershon AA, European Working Group on Varicella .Consensus: Varicella Vaccination of Healthy Children- A Challenge for Europe. Pediatr Infect Dis J 2004 ;23(5):379-389
  • Myers MG, Stanberry LR. Varicella-Zoster Virus. In: Behrman RE, Kliegman RM, Jenson HB(eds). Nelson Textbook of pediatrics, 16 ed. Philadelphia:W.B SaundersCompany, 2000: 973-977
  • Echevarria JM, Casas I, Martinez-Martin P. Infections of the nervous system caused by varicella-zoster virus. Intervirology 1997; 40: 72-84.
  • Kleinschimidt BK,Gilden DH.Varicella-zoster virus infections of the nervous system: Clinical and Pathologic Correlates.Arch Pathol Lab Med 2001;125:770-780
  • Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura.Transfusion Science 1998; 19: 253-259.
  • Ziebold C, von Kries R, Lang R, Weigl J, Schmitt HJ. Severe complications of varicella in previously healthy children in Germany: a 1-year survey. Pediatrics 2001 ;108(5):E79
  • Kanra G, Tezcan S,Badur S andTurkish National Study Team. Varicella seroprevalence in a random sample of theTurkish population.Vaccine 2002;20:1425-1428
  • Koskiniemi M, Piiparinen H, Rantalaiho T, Eränkö P, Färkkilä M, Räihä K, Salonen E, Ukkonen P, Vaheri A and The Study Group. Acute central nervous system complicationsin varicella zoster virusinfections.JClin Virol 2002; 25: 293-301.
  • Ho-Yen DO,Hardie R,Sommerville RG. Varicellainduced thrombocytopenia. JInfect 1984; 8: 274276.

Two Patients With Aseptic Menıngitis and Immune Trombocytopenic Purpura Following Chickenpox

Year 2005, Volume: 6 Issue: 2, 39 - 41, 01.08.2005

Abstract

Chickenpox is the primary infection of varicella zoster virus. The viscera and central nervous system can be affected due to viremia of VZV. Neurologic complications are among the most frequent indications for hospitalization of children with varicella. Furthermore, they can be seen in the absence of characteristic cutaneous rash. Haemorrhagic complications of varicella are rare in childhood. Varicella can cause trombocytopenia and disseminated hemorrhagic lesions in immunocompromised children. Trombocytopenia may begin 1 to 2 weeks or more after varicella. In this paper, a seven year old male with aseptic meningitis anda six year old male with immune trombocytopenic purpura (ITP) following varicella are presented. Both of them had resolving cutaneous rashes of varicella. The patient with aseptic meningitis recovered spontaneously; on the otherhand, the patient with ITP responded to metil prednisolone treatment. Due to these two cases, it is stressed that varicella can be complicated and it can be prevented with vaccine.

References

  • Rentier B, Gershon AA, European Working Group on Varicella .Consensus: Varicella Vaccination of Healthy Children- A Challenge for Europe. Pediatr Infect Dis J 2004 ;23(5):379-389
  • Myers MG, Stanberry LR. Varicella-Zoster Virus. In: Behrman RE, Kliegman RM, Jenson HB(eds). Nelson Textbook of pediatrics, 16 ed. Philadelphia:W.B SaundersCompany, 2000: 973-977
  • Echevarria JM, Casas I, Martinez-Martin P. Infections of the nervous system caused by varicella-zoster virus. Intervirology 1997; 40: 72-84.
  • Kleinschimidt BK,Gilden DH.Varicella-zoster virus infections of the nervous system: Clinical and Pathologic Correlates.Arch Pathol Lab Med 2001;125:770-780
  • Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura.Transfusion Science 1998; 19: 253-259.
  • Ziebold C, von Kries R, Lang R, Weigl J, Schmitt HJ. Severe complications of varicella in previously healthy children in Germany: a 1-year survey. Pediatrics 2001 ;108(5):E79
  • Kanra G, Tezcan S,Badur S andTurkish National Study Team. Varicella seroprevalence in a random sample of theTurkish population.Vaccine 2002;20:1425-1428
  • Koskiniemi M, Piiparinen H, Rantalaiho T, Eränkö P, Färkkilä M, Räihä K, Salonen E, Ukkonen P, Vaheri A and The Study Group. Acute central nervous system complicationsin varicella zoster virusinfections.JClin Virol 2002; 25: 293-301.
  • Ho-Yen DO,Hardie R,Sommerville RG. Varicellainduced thrombocytopenia. JInfect 1984; 8: 274276.
There are 9 citations in total.

Details

Other ID JA33CG66CS
Journal Section Case Report
Authors

S. Ayvaz Aydoğdu This is me

Tolga Ünüvar This is me

Ömer Söz This is me

Ayşe Yenigün This is me

Publication Date August 1, 2005
Published in Issue Year 2005 Volume: 6 Issue: 2

Cite

EndNote Aydoğdu SA, Ünüvar T, Söz Ö, Yenigün A (August 1, 2005) Two Patients With Aseptic Menıngitis and Immune Trombocytopenic Purpura Following Chickenpox. Meandros Medical And Dental Journal 6 2 39–41.