PRETERM DOĞUM EYLEMİNİN TEDAVİSİNDE NİFEDİPİN İLE HİDRASYON+SEDASYON'UN KARŞILAŞTIRILMASI: PROSPEKTİF KLİNİK BİR ÇALIŞMA

Year 2007, Volume: 8 Issue: 1, 23 - 26, 01.04.2007

Cenk Naykı Murat İnal Yusuf Yıldırım Şivekar Tınar

Abstract

Amaç:Preterm eylem tedavisinde hidrasyon+sedasyon ile nifedipin'in etkinliğini karşılaştırmak.Yöntem:Çalışmaya Kasım 2003-Mart 2005 tarihleri arasında hastanemizde preterm doğum eylemi nedeniylehospitalize edilen toplam 130 gebe dahil edildi. Bu gebelerin 70'i (Grup 1) hidrasyon+sedasyon, 60'ı (Grup 2) isenifedipin aldı. Tüm gebeler doğuma kadar takip edildi ve obstetrik ve perinatal veriler kaydedildi.Bulgular:Gruplar demografik ve reprodüktif özellikler, preterm eylem için risk faktörleri, başvuru anındakigebelik haftası ve sonografik olarak ölçülen servikal uzunluk açısından benzerdi (p>0.05). Tanıdan doğumakadar geçen ortalama süre Grup 1'de 35.8±4.2 gün, Grup 2'de ise 35.4±4.5 gündü (p=0.84). Ortalama doğumağırlığı ise Grup 1'de 2970±226 gram, Grup 2'de 2880±231 gram'dı (p=0.17). Parenteral tokoliz ihtiyacı(p=0.07) ve 37. gebelik haftasından önce doğum (p=0.62) oranları açısından da gruplar arasında anlamlı farklılıksaptanmadı.Sonuç:Literatür verilerinin aksine, çalışmamızın sonuçları preterm doğum eyleminin başlangıç yönetimindetokoliz uygulamadan önce hidrasyon+sedasyon tedavisinin mantıklı bir yaklaşım olacağını desteklemektedir.Bununla birlikte bu yaklaşımı tokoliz tedavisine alternatif olarak önerebilmek için daha geniş ve plasebokontrollü çalışmalara ihtiyaç vardır

Keywords

Preterm doğum, hidrasyon+sedasyon, nifedipin

Comparison of Nifedipine and Hydration + Sedation in the Treatment of Preterm Delivery: A Prospective Clinical Study

Abstract

Purpose: To compare the effectiveness of hydration + sedation and nifedipine in the treatment of preterm delivery. Methods: Between November 2003 and March 2005, a total of 130 pregnant women hospitalized at our hospital due to preterm labor were enrolled in the study. Of these, 70 (group 1) received hydration+sedation and the remaining 60 (group 2) received nifedipine. All pregnant women were followed up to delivery and obstetric and perinatal data were recorded. Results: Groups were similar with respect to patients' demographic and reproductive characteristics, risk factors for preterm delivery, gestational week at the time of application and cervical length measured by ultrasound (p>0.05). Mean time between diagnosis and delivery was 35.8±4.2 days in group 1 and was 35.4±4.5 days in group 2 (p=0.84). Mean birth weight was 2970±226 grams for group 1 and was 2880±231 grams for group 2 (p=0.17). There was also no significant difference between the groups with respect to parenteral tocolysis requirement (p=0.07) and delivery prior to 37 weeks of gestation (p=0.62). Conclusion: In contrast to literature data, our study results suggest that hydration + sedation treatment may be a reasonable approach before administrating tocolysis. However, larger and placebo controlled studies are needed to recommend this approach as an alternative to tocolysis.

Keywords

Preterm delivery, hydration+sedation, nifedipine

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