TİROİDİN ONKOSİTİK DEĞİŞİKLİK GÖSTEREN TÜMÖRLERİNE DÖRT OLGU EŞLİĞİNDE GENEL BAKIŞ

Year 2007, Volume: 8 Issue: 1, 35 - 37, 01.04.2007

Canten Tataroğlu Zehra Kesen

Abstract

Tiroid follikül epitel hücrelerindeki onkositik değişiklikler benign uçta Hashimoto tiroiditi, malign uçta Hurthle
hücreli karsinom yada medüller karsinom gibi geniş bir spektrumda izlenebilirler. Biz onkositik değişiklik
gösteren dört tiroid tümörünü histopatolojik özellikleriyle tartıştık. Olguların üçü kadın biri erkektir. Tümörlerin
boyutları 1-6 cm arasındadır. Histolojik olarak tüm tümörlerde follikül epitel hücrelerinde onkositik değişiklikler
izlenmiştir. İki olguda papiller yapılanma izlenirken diğer ikisinde folliküler büyüme paterni izlenmiştir. Bir
olguda tiroid papiller karsinomda tipik olarak izlenen nükleuslarda saydamlaşma dikkati çekmiştir. Diğer
vakalarda nükleuslar vesiküle olup belirgin nükleol içermektedir.İki olguda tümör çevresindeki tiroid dokusunda
Hashimoto tiroiditi bulguları izlenmiştir. Histopatolojik olarak birbirine benzeyen ve zaman zaman tanı zorluğu
yaratan biyolojik davranış ve prognoz farklılığı göst mörü sunulmuştur.

Keywords

Hurthle hücresi, papiller karsinom, adenom, tiroid

General Features of Four CasesWith Oncocytic Change in Thyroid Tumors

Abstract

Oncocytic change in thyroid follicular cells can take place in a range of pathological conditions with Hashimoto's thyroiditis on the benign and Hurthle cell carcinoma or medullary carcinoma on the malignant ends of the spectrum.We evaluated four cases of thyroid tumors composed of oncocytic cells. Three patients were women and one was a man. The tumors measured between 1 to 6 cm. Histologically all tumors showed oncocytic change in thyroid follicular cells.Two cases showed papillary features, and in the others the follicular growth pattern was predominant. In one case, the classical optically clear nuclei of papillary carcinoma were present. The rest had vesicular nuclei and prominent nucleoli. In two cases the peritumoral area showed the features of Hashimoto's thyroiditis. We report 4 cases with oncocytic thyroid neoplasms that might have different biological and prognostic features.

Keywords

Hurthle cell, papillary carcinoma, adenoma, thyroid

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