PARKİNSON HASTALIĞINDA OBSESİF KOMPULSİF BOZUKLUK

Year 2008, Volume: 9 Issue: 1, 19 - 21, 01.04.2008

Tugba Tunç Özlem Coşkun Gökhan Özer Ufuk Emre Esra Okuyucu Serpil Yandı Vargel Levent Ertuğrul İnan

Abstract

-

Keywords

Parkinson hastalığı, obsesif kompulsif hastalık, motor komplikasyonlar

Obsessive- Compulsive Disorder in The Parkinson Disease

Abstract

Obsessive disorder assessment using Leyton Obsessional Inventory was done in patients with
idiopathic Parkinson's Disease.
Fifty patients diagnosed with Parkinson's disease according to United Kingdom
Parkinson's Disease Society Brain Bank (UK-PDSBB) criteria and 37 healty individuals were included in the
study.All subjects were assesed by the same psychiatrist using the Leyton obsessional inventory.
he Leyton obssesional scores were higher in the Parkinson's disease group than in the control group
(p<0,001). In addition, correlation was found between the severity of disease and degree of obsession (p:0,771).
Parkinson's disease is a neurodejenerative disorder with predominant motor symptoms but with
progression , nonmotor symptoms also emerge. The patient's qualty of life may be much affected by these
nonmotor symptoms. Diagnosis and treatment of the pyschiatric symptoms in Parkinson's disease may help
improve life quality.

Keywords

Parkinson disease, obsessive-compulsive disorder, motor complications

References

• 1. Rasmussen SA and Eisen JL. The epidemiological and clinical features of obsessivecompulsive disorder. In: Jenike MA, editor, The Psychiatric Clinics of North America. Obsessional Disorders, WB Saunders Company, Chicago, 1992: 74358.
• 2. Robinson D, Wu H, Munne RA, Ashtari M, Alvir JM, Lerner G, Koreen A, Cole K, Bogerts B. Reduced caudate nucleus volume in obsessive-compulsive disorder.Arch Gen Psychiatry 1995; 52: 393-8.
• 3. Tomer R, Levin BE, Weiner WJ. Obsessive￾compulsive symptoms and motor asymmetries in Parkinson's disease. Neuropsychiatry Neuropsychol Behav Neurol 1993; 6: 26-30
• 4. Alegret M, Junqué C, Valldeoriola F, Vendrell P, Martí MJ, Tolosa E. Obsessive-compulsive symptoms in Parkinson's disease. J Neurol Neurosurg Psychiatry 2001; 70(3): 394-6.
• 5. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neuro Neurosurg Psychiatry 1988; 51: 745-52.
• 6. Poewe W. The natural history of Parkinson's disease. J Neurol 2006; 253 Suppl 7: VII2-6.
• 7. Cooper J. The Leyton obsessional inventory. Psychol Med 1970; 1: 48-64.
• 8. Shiba M, Bower JH, Maraganore DM, McDonnell SK, Peterson PJ, Ahlskog JE, Schaid DJ, Rocca WA. Anxiety disorders and depressive disorders preceding Parkinson's disease: a case control study. Mov Disord 2000; 15: 669-77.
• 9. Henninger GR, Charney DS. Monoamine receptor systems and anxiety disorders. Psychiatry Clin North Am 1988; 11: 309-26.
• 10. Iruela LM, Ibanez-Rojo V, Inmaculada P. Anxiety dsorders and Parkinson's disease. Am J Psychiatry 1992; 149: 719-20.
• 11. Schrag A. Psychiatric aspects of Parkinson's disease. An upgate. J Neurol 2004; 251: 795-804.
• 12. Aarsland D, Larsen JP, Lim NG, Janvin C, Karlsen K, Tandberg E, Cummings JL. Range of neuropsychiatric disturbances in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1999; 67: 492-6.
• 13. Beck, A.T., Epstein, N., Brown, G., Steer, R.A. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988; 56: 893-7.
• 14. Ulusoy M. Beck Anksiyete Ölçeğinin Psikometrik Özellikleri. Uzmanlık Tezi, İstanbul: Bakırköy Ruh ve Sinir Hastalıkları Hastanesi, Psikiyatri Bölümü, 1993.
• 15. Walsh K, Bennett G. Parkinson's disease and anxiety. Postgrad Med J 2001; 77: 89-93.
• 16. Baxter LR, Phelps ME, Mazziotta JC, et al. Local cerebral glucose metabolic rates in obsessive￾compulsive disorder: a comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 1987; 44: 211-8.
• 17. Laplane D, Lavasseur M, Pillon B, et al. Obsessive￾compulsive and other behavioural changes with bilateral basal ganglia lesions. A neuropsychological magnetic resonance imaging and positron tomography study. Brain 1989; 112: 699-725.
• 18. Cummings JL. Frontal-subcortical circuits and human behavior.Arch Neurol 1993; 50: 873-80.
• 19. Frankel M, Cummings JL, Robertson MM, et al. Obsessions and compulsions in Gilles de la Tourette's syndrome. Neurology 1986; 36: 378-82.
• 20. Lang AE, Lozano AM. Parkinson's disease. N Engl J Med 1998; 339: 1130-43.
• 21. Saint-Cyr JA, Taylor AE, Nicholson K. Behavior and the basal ganglia.Adv Neurol 1995; 65: 1-28.
• 22. Austin MP, Mitchell P. The anatomy of melancholia: does frontal-subcortical pathophysiology underpin its psychomotor and cognitive manifestations? Psychol Med 1995; 25: 665-72.