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HÜCRE SİKLUSU VE KANSER

Year 2008, Volume: 9 Issue: 3, 51 - 61, 01.12.2008

Abstract

Hücre çoğalması ve hücre siklusunun ilerlemesi büyümenin kontrolünde rolü olan genlerin ekspresyonu ilebağlantılıdır. Ökaryot hücre siklusu M (mitoz) G , S ve G fazlarından oluşmaktadır. Bu süreçte hücre uyarımı vebüyüme meydana gelir veya hücre G fazında durmaktadır. Hücre siklusunda G -S geçişinde, G -M geçişinde vemetafaz-anafaz geçişinde kontrol noktaları bulunmaktadır. Hücre siklusu siklin bağımlı kinazlar (cdk, katalitikaltbirim) ve siklin (cyc, düzenleyici altbirim) tarafından kontrol edilmektedir. Hücre homeostazisi hücreçoğalması, büyümenin durdurulması ve apoptozis (programlı hücre ölümü) ile sürdürülmektedir. Hücre siklusuiçindeki olayları düzenleyen ve kontrol eden etkileşimler çok sayıda ve komplekstir. Hücre siklusunundüzenlenmesindeki hatalar hücre bölünmesinin kontrolunun bozulmasına neden olur. Hücre siklusu kontrolnoktalarında değişimler kanser gelişimine neden olabilir. Kanser gelişiminde tümör baskılayıcı fonksiyon, DNAonarımı ve apoptozis kritik yolaklardır

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Cell Cycle and Cancer

Year 2008, Volume: 9 Issue: 3, 51 - 61, 01.12.2008

Abstract

Proliferation and cell cycle progression are linked to the expression of genes associated with growth control. The eucaryotic cell cycle consists of an M (mitotic) phase, a G phase, the S phase and G phase. Non-dividing cells exist at G . Cell cycle is regulated by several critical cell cycle check points These are G -S check point, G -M check point and metaphase-anaphase check point. Cell cycle is controlled by the cycline dependent kinases (cdk, catalytic subunit) and cyclins (cyc, regulatory subunit). Homeostasis is within a cell is regulated by the balance between proliferation, growth arrest and apopto sis. Defects in cell cycle regulation inhibit controls for cell division. Alterations of cell cycle check points might result in cancer. The interactions which control and regulate the cascade of events within cell cycle are numerous and complex. Tumor supression of growth arrest, DNA repair and apoptosis, are all critical pathways in the development of cancers.

References

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There are 94 citations in total.

Details

Other ID JA76YP85AG
Journal Section Research Article
Authors

Hülya Cabadak This is me

Publication Date December 1, 2008
Published in Issue Year 2008 Volume: 9 Issue: 3

Cite

EndNote Cabadak H (December 1, 2008) Cell Cycle and Cancer. Meandros Medical And Dental Journal 9 3 51–61.