Evaluation of Premature Newborn with Patent Ductus Arteriosus

Year 2013, Volume: 14 Issue: 1, 11 - 15, 01.04.2013

Ayvaz Aydoğdu Defne Engür Bilin Çetinkaya Çakmak Ali Rahmi Bakiler Münevver Kaynak Türkmen

Abstract

OBJECTIVE: Patent ductus arteriosus (PDA) with significant left to right shunt is related to increased neonatal morbidity and mortality in premature babies. In this retrospective study, premature newborns with PDA followed in our unit were evaluated especially with regard to effect of PDA diameter on the outcome. MATERIALS and METHODS: Premature babies (n=407; gestational age <37 weeks) followed in Adnan Menderes University Faculty of Medicine NICU between years 2005-2009 were included in the study. Thirtythree of them with haemodynamically significant (hs) PDA were determined. Demographic data, clinical features, respond to therapy and complications were investigated. RESULTS: Mean gestational age was 30.1±2.8 weeks and mean birth weight was 1602±553 g. Symptomatic PDA incidence among premature babies was 8.1%. Spontaneous closure was observed in 27% of the cases (all had ductus diameter of <2.5 mm). Twenty-four babies were given ibuprofen (19 intravenously, 5 per oral), closure was obtained in 13 cases. Success rate of ibuprofen therapy was 54%. Surgical ligation was needed in 12% of the ases. None of the cases with <2.5 mm PDA required surgery, whereas surgical ligation was performed in 24% of cases with ≥2.5 mm PDA. Local infection in one case and chylothorax in another case were seen as surgical complications. CONCLUSION: Factors affecting the clinical outcome of premature infants suffering from PDA were investigated in this study. Better prognosis was seen when ductus diameter is <2.5 mm.

Keywords

Patent ductus arteriosus, newborn, intensive care unit

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• Yrd. Doç. Dr Ayvaz AYDOÐDU
• Adnan Menderes Üniversitesi Týp Fakültesi,
• Pediatrik Kardiyoloji BD, AYDIN, TÜRKÝYE E- Posta
• : [e-mail] Geliþ Tarihi Kabul Tarihi : 14.03.2013