PROPOFOLE BAĞLI NÖBET BENZERİ AKTİVİTE: OLGU SUNUMU

Year 2013, Volume: 14 Issue: 2, 35 - 37, 01.08.2013

Menşure Kaya İlker Yiğit Müge Ceylan Hamit Erdal Eskiçırak Nihal Kadıoğulları

Abstract

Propofol kısa etki süresi nedeniyle anestezi ve sedasyon için yaygın olarak kullanılan bir ilaçtır. Antikonvülzan olarak status epileptkus tedavisinde önerilmekle birlikte, epileptik hastalık ve kafa travması öyküsü olan hastalarda özellikle de düşük dozlarda kullanıldığında nöbet benzeri aktivite oluşturduğu bildirilmiştir. Sağ humerus proksimalinde basit kist nedeniyle biyopsi işlemi planlanan 27 yaşında kadın hastaya propofol 3 mg kg1 iv verildikten sonra bir dakika içinde hem alt hem üst ekstremitelerde tonik klonik tarzda kasılmalar gözlendi. Bu kasılmalar tiyopental uygulanarak kontrol altına alındı. Anestezi uygulamaları için çok sık kullanılan propofolün tamamen sağlıklı bireylerde ve yüksek dozda kullanıldığında da nöbet benzeri aktivite oluşturabileceğine dikkat çekmek ve tartışmak istedik

Keywords

Genel anestezi, propofol, tonik klonik konvülziyon

Propofol Induced Seizure Like Activity: A Case Report

Abstract

Propofol is a widely used drug because of short acting time for anesthesia and sedation. Although ıt has been suggested as a anticonvulsant in treatment of status epilepticus, it has been also reported to induce seizure like activity in patients with epilepsia and head injury especially in low dose. A few minutes after giving propofol 3 mg kg-1 iv to a 27 years old female patient scheduled for biopsy of a simple cyst in the right proximal humerus, tonicclonic convulsions were observed both in the upper and lower extremities. Convulsions were managed by administering thiopental. We want to discuss and point to that propofol which is frequently used for anesthetic procedures may induce seizure like activity in exactly healty people.

Keywords

General anesthesia, propofol, tonic clonic convulsion

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