A Vitamini Tedavisinin Kuru Göz Hastalığına Olan Etkisi

Year 2014, Volume: 15 Issue: 2, 0 - 0, 01.08.2014

Tolga Kocatürk Faruk Balıca Harun Çakmak

Abstract

AMAÇ: Topikal uygulanan A vitamininin kuru göz hastalarında gözyaşı kırılma zamanı (GKZ), korneal boyanma skoru ve oküler yüzey hastalık indeksi (OYHİ) üzerine olan etkilerinin araştırılması amaçlanmıştır.GEREÇ VE YÖNTEMLER: Çalışmaya 15 hastanın 30 gözü dahil edildi. Ek oküler yüzey hastalığı olmayan, göz ameliyatı geçirmemiş ve OYHİ değeri 25’in üzerinde olan semptomatik kuru göz hastalarına 2 aylık topikal Vitamin A tedavisi (Vit-A Pos oft pomad 2x1) uygulandı. Tedavi sonrasındaki GKZ değerleri, Oxford evreleme şeması ile boyanma skorları ve OYHİ skorları tedavi öncesi değerlerle karşılaştırıldı.BULGULAR: Tedavi öncesi ortalama GKZ değeri 2,26±0,59 sn, boyanma skoru 2,53±0,74, OYHİ skoru 45±13,82 olarak bulundu. 2 aylık A vitamini tedavisi sonrasında hastaların şikayetlerinde belirgin derecede azalma olduğu öğrenildi; tedavi sonrası ortalama GKZ değeri 2,93±1,22 sn, boyanma skoru 2,06±0,79 ve OYHİ skoru 29,66±12,53 olarak bulundu. Tedavi öncesi ve sonrası değerler karşılaştırıldığında, değişimlerin istatisiksel olarak anlamlı olduğu görüldü; p değerleri GKZ için 0,027, boyanma skoru için 0,029 ve OYHİ için <0,01 olarak belirlendi. Hiçbir hastada yan etki görülmedi.SONUÇ: Vitamin A tedavisinin kuru göz hastalarının şikayetlerini azalttığı görüldü. Boyanma skorunda ve özellikle OYHİ skorunda belirgin bir azalmaya, GKZ değerinde ise anlamlı bir artışa neden olduğu görüldü. A vitamini kuru göz hastalarında semptomatik iyileşme sağlamaktadır ve kuru göz hastalarının tedavisinde alternatif bir tedavi olarak düşünülmelidir

Keywords

Kuru göz, A vitamini, gözyaşı kırılma zamanı, Oxford korneal boyanma skalası, oküler yüzey hastalık indeksi

The Effects of Vitamin A Treatment on Dry Eye Disease

Abstract

OBJECTIVE: To investigate the effect of topically administered vitamin A on break up time (BUT), corneal staining score and ocular surface disease index (OSDI) in dry eye patients. MATERIALS AND METHODS: Thirty eyes of 15 patients were included in the study. Topical Vitamin A (Vit-A Pos pomad) twice a day was administered for 2 months to the semptomatic dry eye patients who have not undergone any ocular surgery, who have not got any additional ocular surface disease and who have an OSDI score of >25. BUT values, corneal staging scores with Oxford grading scale and OSDI scores after the treatment were compared with the values before the treatment. RESULTS: Mean age of the patients was 54.26±12.89. The means of BUT, corneal staining and OSDI scores before the treatment were 2.26±0.59, 2.53±0.74 and 45±13.82, respectively. After 2 mo Vitamin A treatment, patients’ complaints decreased, the means of BUT, corneal staining and OSDI scores after the treatment were found to be 2.93±1.22, 2.06±0.79 and 29.66±12.53, respectively. When compared the values before and after the treatment, differences were seen to be statically significant. P values were 0.027, 0.029 and <0.01 for BUT, corneal staining and OSDI scores, respectively. None of the patients complained about adverse effect. CONCLUSION: Vitamin A treatment was seen to reduce the complaints of dry eye patients. It was resulted in a significant decresae in especially OSDI and corneal staining scores, also a significant increase in BUT value. Vitamin A provides a symptomatic improvement in dry eye patients and should be considered as an alternative treatment in symptomatic dry eye patients.

Keywords

Dry eye, vitamin A, break up time, Oxford corneal staining scale, ocular surface disease index

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