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Ön Kamaraya Yüksek Doz Sefuroksim Verilmesi Sonucu Oküler Toksisite

Year 2016, Volume: 17 Issue: 2, 113 - 115, 01.08.2016

Abstract

Sefalosporinler, beta-laktam türevi antibiyotiklerdir ve penisilinler gibi bakteri hücre duvarı sentezini bozarak bakteriyostatik etki gösterirler. Sefuroksim 2. kuşak sefalosporindir ve özellikle intrakamaral yolla sefuroksim kullanımı katarakt cerrahisi endoftalmi profilaksisinde yaygın olarak kullanılmaktadır. Yetmiş sekiz yaşındaki erkek hasta yaklaşık 8 yıl önce her iki gözünden katarakt nedeniyle ameliyat olmuş. Dokuz ay önce de sol gözünde meydana gelen oküler travma nedeniyle hastaya vitrektomi ameliyatı ile birlikte intraoküler lens çıkarımı uygulanmış ve hasta afak bırakılmış. Hastaya merkezimizde sekonder göz içi lens implantasyonu uygulanmıştır. Sekonder göz içi lens implantasyonu sonrasında sefuroksimin ön kamaraya olması gereken dozun 2,5 katı (25 mg/ml) düzeyinde yanlışlıkla verilmesi sonrasında ortaya çıkan göz bulguları sunulmuştur

References

  • 1. Eser İ. Katarakt cerrahisi sonrası endoftalmi profilaksisi. Glokom Katarakt Dergisi. 2009; 4: 205-9.
  • 2. Yu-Wai-Man P, Morgan SJ, Hildreth AJ, Steel DH, Allen D. Efficacy of intracameral and subconjunctival cefuroxime in preventing endophthalmitis after cataract surgery. J Cataract Refract Surg 2008; 34: 447-51.
  • 3. Vazirani J, Basu S. Role of topical, subconjunctival, intracameral, and irrigative antibiotics in cataract surgery. Curr Opin Ophthalmol 2013; 24: 60-5.
  • 4. Keating GM. Intracameral cefuroxime: prophylaxis of postoperative endophthalmitis after cataract surgery. Drugs 2013; 73: 179-86.
  • 5. Montan PG, Wejde G, Setterquist H, Rylander M, Zetterström C. Prophylactic intracameral cefuroxime. Evaluation of safety and kinetics in cataract surgery. J Cataract Refract Surg 2002; 28: 982- 7.
  • 6. Özlem TY, Necati DM, Fatma YM, Gülsen Y, Ayşe NB, Firdevs O. Are cefuroxime and vancomycin really safe on the corneal endothelial cells? Graefes Arch Clin Exp Ophthalmol 2010; 248: 415-20.
  • 7. Olavi P. Ocular toxicity in cataract surgery because of inaccurate preparation and erroneous use of 50 mg⁄ml intracameral cefuroxime. Acta Ophthalmol 2012; 90: 153-4.
  • 8. Sakarya Y, Sakarya R. Cefuroxime dilution error. Eur J Ophthalmol 2010; 20: 460-1.

Ocular Toxicity after High-Dose Cefuroxime Injection into the Anterior Chamber

Year 2016, Volume: 17 Issue: 2, 113 - 115, 01.08.2016

Abstract

Cephalosporins are beta-lactam antibiotics and, like penicillin derivatives, they show bacteriostatic effect by disrupting bacterial cell wall synthesis. Cefuroxime is a second generation cephalosporin and the use of intracameral cefuroxime after cataract surgery has been widely used in the endophthalmitis prophylaxis. A 78-year-old male patient was operated for cataracts in both eyes about 8 years ago. Ocular trauma has occurred in the left eye nine months ago. Vitrectomy surgery combined with intraocular lens extraction was performed and the patient was left aphakic. Secondary intraocular lens implantation was performed. In this paper, we present postoperative ocular findings in a patient who was given cefuroxime into the anterior chamber 2.5 times higher than the recommended dose (25 mg/ml) after secondary intraocular lens implantation.

References

  • 1. Eser İ. Katarakt cerrahisi sonrası endoftalmi profilaksisi. Glokom Katarakt Dergisi. 2009; 4: 205-9.
  • 2. Yu-Wai-Man P, Morgan SJ, Hildreth AJ, Steel DH, Allen D. Efficacy of intracameral and subconjunctival cefuroxime in preventing endophthalmitis after cataract surgery. J Cataract Refract Surg 2008; 34: 447-51.
  • 3. Vazirani J, Basu S. Role of topical, subconjunctival, intracameral, and irrigative antibiotics in cataract surgery. Curr Opin Ophthalmol 2013; 24: 60-5.
  • 4. Keating GM. Intracameral cefuroxime: prophylaxis of postoperative endophthalmitis after cataract surgery. Drugs 2013; 73: 179-86.
  • 5. Montan PG, Wejde G, Setterquist H, Rylander M, Zetterström C. Prophylactic intracameral cefuroxime. Evaluation of safety and kinetics in cataract surgery. J Cataract Refract Surg 2002; 28: 982- 7.
  • 6. Özlem TY, Necati DM, Fatma YM, Gülsen Y, Ayşe NB, Firdevs O. Are cefuroxime and vancomycin really safe on the corneal endothelial cells? Graefes Arch Clin Exp Ophthalmol 2010; 248: 415-20.
  • 7. Olavi P. Ocular toxicity in cataract surgery because of inaccurate preparation and erroneous use of 50 mg⁄ml intracameral cefuroxime. Acta Ophthalmol 2012; 90: 153-4.
  • 8. Sakarya Y, Sakarya R. Cefuroxime dilution error. Eur J Ophthalmol 2010; 20: 460-1.
There are 8 citations in total.

Details

Other ID JA49GG32AP
Journal Section Case Report
Authors

Harun Çakmak This is me

Mehmet Özbağçıvan This is me

Tolga Kocatürk This is me

Sema Oruç Dündar This is me

Publication Date August 1, 2016
Published in Issue Year 2016 Volume: 17 Issue: 2

Cite

EndNote Çakmak H, Özbağçıvan M, Kocatürk T, Dündar SO (August 1, 2016) Ocular Toxicity after High-Dose Cefuroxime Injection into the Anterior Chamber. Meandros Medical And Dental Journal 17 2 113–115.