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Astımlı Hastalarda Ev İçi Ortam Özelliklerinin Ev Tozu Akar Allerjeni Der p2 ve Der f2 Saptanmasına Etkisi

Year 2016, Volume: 17 Issue: 3, 129 - 137, 01.12.2016

Abstract

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References

  • 1. Gaffin JM, Phipatanakul W. The role of indoor allergens in the development of asthma. Curr Opin Allergy Clin Immunol 2009; 9: 128-35.
  • 2. Sherrill D, Stein R, Kurzius-Spencer M, Martinez F. On early sensitization to allergens and development of respiratory symptoms. Clin Exp Allergy 1999; 29: 905-11.
  • 3. Barnes C, Tuck J, Simon S, Pacheco F, Hu F, Portnoy J. Allergenic materials in the house dust of allergy clinic patients. Ann Allergy Asthma Immunol 2001; 86: 517-23.
  • 4. Jaakkola MS, Ieromnimon A, Jaakkola JJ. Are atopy and specific IgE to mites and molds important for adult asthma? J Allergy Clin Immunol 2006; 117: 642-8.
  • 5. Brunetto B, Barletta B, Brescianini S, Masciulli R, Perfetti L, Moscato G, et al. Differences in the presence of allergens among several types of indoor environments. Ann Ist Super Sanita 2009; 45: 409-14.
  • 6. Ulrik CS, Backer V, Hesse B, Dirksen A. Risk factors for development of asthma in children and adolescents: findings from a longitudinal population study. Respir Med 1996; 90: 623- 30.
  • 7. Korsgaard J. House-dust mites and asthma. A review on housedust mites as a domestic risk factor for mite asthma. Allergy 1998; 53: 77-83.
  • 8. Trombone AP, Tobias KR, Ferriani VP, Schuurman J, Aalberse RC, Smith AM, et al. Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis. Clin Exp Allergy 2002; 32: 1323-8.
  • 9. Kattan M, Mitchell H, Eggleston P, Gergen P, Crain E, Redline S, et al. Characteristics of inner-city children with asthma: the National Cooperative Inner-City Asthma Study. Pediatr Pulmonol 1997; 24: 253-62.
  • 10. Gulbahar O, Mete N, Kokuludag A, Sin A, Sebik F. House dust mite allergens in Turkish homes. Allergy 2004; 59: 231.
  • 11. Ceylan E, Ozkutuk A, Ergor G, Yucesoy M, Itil O, Caymaz S, et al. Fungi and indoor conditions in asthma patients. J Asthma 2006; 43: 789-94.
  • 12. Yazicioglu M, Asan A, Ones U, Vatansever U, Sen B, Ture M, et al. Indoor airborne fungal spores and home characteristics in asthmatic children from Edirne region of Turkey. Allergol Immunopathol (Madr) 2004; 32: 197-203.
  • 13. Kalpaklioglu AF, Emekci M, Ferizli A, Misirligil Z, House-Dust Mite Working G. A survey of acarofauna in Turkey: comparison of seven different geographic regions. Allergy Asthma Proc 2004; 25: 185-90.
  • 14. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2006 [cited 2007 July 7]. Global Initiative for Asthma (GINA).
  • 15. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995; 152: 1107-36.
  • 16. Maestrelli P, Zanolla L, Puccinelli P, Pozzan M, LM; F, Regione Veneto Study Group. Low domestic exposure to house dust mite allergens (Der p1) is associated with a reduced non-specific bronchial hyper-responsiveness in mite-sensitized asthmatic cases under optimal drug treatment. Clin Exp Allergy 2001; 31: 715-21.
  • 17. (2008) Available from: http://inbio.com/UK/images/pdfs/ELD2_CoA.pdf EPfMGAIIBMGEkDAPCE-DLNxS.
  • 18. Arbes SJ, Jr., Cohn RD, Yin M, Muilenberg ML, Burge HA, Friedman W, et al. House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing. J Allergy Clin Immunol 2003; 111: 408-14.
  • 19. Fahlbusch B, Heinrich J, Gross I, Jager L, Richter K, Wichmann HE. Allergens in house-dust samples in Germany: results of an EastWest German comparison. Allergy 1999; 54: 1215-22.
  • 20. Dharmage S, Bailey M, Raven J, Cheng A, Rolland J, Thien F, et al. Residential characteristics influence Der p 1 levels in homes in Melbourne, Australia. Clin Exp Allergy 1999; 29: 461-9.
  • 21. Simpson A, Simpson B, Custovic A, Cain G, Craven M, Woodcock A. Household characteristics and mite allergen levels in Manchester, UK. Clin Exp Allergy 2002; 32: 1413-9.
  • 22. Arlian LG, Platts-Mills TA. The biology of dust mites and the remediation of mite allergens in allergic disease. J Allergy Clin Immunol 2001; 107: 406-13.
  • 23. Reisacher WR. Allergy treatment: environmental control strategies. Otolaryngol Clin North Am 2011; 44: 711-25, x.
  • 24. Cho SH, Reponen T, Bernstein DI, Olds R, Levin L, Liu X, et al. The effect of home characteristics on dust antigen concentrations and loads in homes. Sci Total Environ 2006; 371: 31-43.
  • 25. Warner A, Bostrom S, Moller C, Kjellman NI. Mite fauna in the home and sensitivity to house-dust and storage mites. Allergy 1999; 54: 681-90.
  • 26. van Strien RT, Koopman LP, Kerkhof M, Oldenwening M, de Jongste JC, Gerritsen J, et al. Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy 2003; 33: 490-5.
  • 27. Paufler P, Gebel T, Dunkelberg H. Quantification of house dust mite allergens in ambient air. Rev Environ Health 2001; 16: 65- 80.
  • 28. Salo PM, Arbes SJ, Jr., Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol 2008; 121: 678- 84.e2.
  • 29. de Blay F, Sanchez J, Hedelin G, Perez-Infante A, Verot A, Chapman M, et al. Dust and airborne exposure to allergens derived from cockroach (Blattella germanica) in low-cost public housing in Strasbourg (France). J Allergy Clin Immunol 1997; 99: 107-12.
  • 30. Lewis SA, Weiss ST, Platts-Mills TA, Burge H, Gold DR. The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma. Am J Respir Crit Care Med 2002; 165: 961-6.
  • 31. Maas T, Rovers JJ, Schonberger HJ, Schayck CP. Distribution of house dust mite allergen: comparing house dust mite allergen levels in dust samples collected from different sites on living room floors with smooth coverings. Allergy 2003; 58: 500-2.

The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics

Year 2016, Volume: 17 Issue: 3, 129 - 137, 01.12.2016

Abstract

Objective: Mites in house dust play a prominent role in the development of allergic sensitization and as a triggering factor that impairs disease control in asthma. The aim of the study was to determine whether the concentration of house dust mite allergens is associated with indoor conditions in stable asthmatics. Materials and Methods: During the study period, a total of 97 asthmatic patients were queried with a standard survey for their demographical characteristics and living environment. House dust samples from their houses were collected to quantitatively measure Dermatophagoides farinae (Der f2) and Dermatophagoides pteronyssinus  (Der p2) levels by using the Enzyme-linked immunosorbent assay (ELISA) method. Results: Using the quantitative ELISA method, measurable levels of mite allergens were found in 54.1% of the houses. Higher antigen detection rate was found in houses with visible mould and in those with moisture. The number of household was found to be significantly higher in houses with antigens than in those without antigens. When the indoor characteristics were evaluated by logistic regression analysis, larger number of household (≥4) was found to be a significant risk factor for the presence of mite allergens. The odds ratio for detecting Der p2 and Der f2 antigen was found to be 5.29 (confidence interval 2.18-12.86) (p<0.001). Conclusion: Mite allergen was detected in the house dusts of more than half of the cases by using quantitative ELISA method. Our results did not found any association between concentrations of allergens and indoor characteristics.

References

  • 1. Gaffin JM, Phipatanakul W. The role of indoor allergens in the development of asthma. Curr Opin Allergy Clin Immunol 2009; 9: 128-35.
  • 2. Sherrill D, Stein R, Kurzius-Spencer M, Martinez F. On early sensitization to allergens and development of respiratory symptoms. Clin Exp Allergy 1999; 29: 905-11.
  • 3. Barnes C, Tuck J, Simon S, Pacheco F, Hu F, Portnoy J. Allergenic materials in the house dust of allergy clinic patients. Ann Allergy Asthma Immunol 2001; 86: 517-23.
  • 4. Jaakkola MS, Ieromnimon A, Jaakkola JJ. Are atopy and specific IgE to mites and molds important for adult asthma? J Allergy Clin Immunol 2006; 117: 642-8.
  • 5. Brunetto B, Barletta B, Brescianini S, Masciulli R, Perfetti L, Moscato G, et al. Differences in the presence of allergens among several types of indoor environments. Ann Ist Super Sanita 2009; 45: 409-14.
  • 6. Ulrik CS, Backer V, Hesse B, Dirksen A. Risk factors for development of asthma in children and adolescents: findings from a longitudinal population study. Respir Med 1996; 90: 623- 30.
  • 7. Korsgaard J. House-dust mites and asthma. A review on housedust mites as a domestic risk factor for mite asthma. Allergy 1998; 53: 77-83.
  • 8. Trombone AP, Tobias KR, Ferriani VP, Schuurman J, Aalberse RC, Smith AM, et al. Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis. Clin Exp Allergy 2002; 32: 1323-8.
  • 9. Kattan M, Mitchell H, Eggleston P, Gergen P, Crain E, Redline S, et al. Characteristics of inner-city children with asthma: the National Cooperative Inner-City Asthma Study. Pediatr Pulmonol 1997; 24: 253-62.
  • 10. Gulbahar O, Mete N, Kokuludag A, Sin A, Sebik F. House dust mite allergens in Turkish homes. Allergy 2004; 59: 231.
  • 11. Ceylan E, Ozkutuk A, Ergor G, Yucesoy M, Itil O, Caymaz S, et al. Fungi and indoor conditions in asthma patients. J Asthma 2006; 43: 789-94.
  • 12. Yazicioglu M, Asan A, Ones U, Vatansever U, Sen B, Ture M, et al. Indoor airborne fungal spores and home characteristics in asthmatic children from Edirne region of Turkey. Allergol Immunopathol (Madr) 2004; 32: 197-203.
  • 13. Kalpaklioglu AF, Emekci M, Ferizli A, Misirligil Z, House-Dust Mite Working G. A survey of acarofauna in Turkey: comparison of seven different geographic regions. Allergy Asthma Proc 2004; 25: 185-90.
  • 14. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2006 [cited 2007 July 7]. Global Initiative for Asthma (GINA).
  • 15. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995; 152: 1107-36.
  • 16. Maestrelli P, Zanolla L, Puccinelli P, Pozzan M, LM; F, Regione Veneto Study Group. Low domestic exposure to house dust mite allergens (Der p1) is associated with a reduced non-specific bronchial hyper-responsiveness in mite-sensitized asthmatic cases under optimal drug treatment. Clin Exp Allergy 2001; 31: 715-21.
  • 17. (2008) Available from: http://inbio.com/UK/images/pdfs/ELD2_CoA.pdf EPfMGAIIBMGEkDAPCE-DLNxS.
  • 18. Arbes SJ, Jr., Cohn RD, Yin M, Muilenberg ML, Burge HA, Friedman W, et al. House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing. J Allergy Clin Immunol 2003; 111: 408-14.
  • 19. Fahlbusch B, Heinrich J, Gross I, Jager L, Richter K, Wichmann HE. Allergens in house-dust samples in Germany: results of an EastWest German comparison. Allergy 1999; 54: 1215-22.
  • 20. Dharmage S, Bailey M, Raven J, Cheng A, Rolland J, Thien F, et al. Residential characteristics influence Der p 1 levels in homes in Melbourne, Australia. Clin Exp Allergy 1999; 29: 461-9.
  • 21. Simpson A, Simpson B, Custovic A, Cain G, Craven M, Woodcock A. Household characteristics and mite allergen levels in Manchester, UK. Clin Exp Allergy 2002; 32: 1413-9.
  • 22. Arlian LG, Platts-Mills TA. The biology of dust mites and the remediation of mite allergens in allergic disease. J Allergy Clin Immunol 2001; 107: 406-13.
  • 23. Reisacher WR. Allergy treatment: environmental control strategies. Otolaryngol Clin North Am 2011; 44: 711-25, x.
  • 24. Cho SH, Reponen T, Bernstein DI, Olds R, Levin L, Liu X, et al. The effect of home characteristics on dust antigen concentrations and loads in homes. Sci Total Environ 2006; 371: 31-43.
  • 25. Warner A, Bostrom S, Moller C, Kjellman NI. Mite fauna in the home and sensitivity to house-dust and storage mites. Allergy 1999; 54: 681-90.
  • 26. van Strien RT, Koopman LP, Kerkhof M, Oldenwening M, de Jongste JC, Gerritsen J, et al. Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy 2003; 33: 490-5.
  • 27. Paufler P, Gebel T, Dunkelberg H. Quantification of house dust mite allergens in ambient air. Rev Environ Health 2001; 16: 65- 80.
  • 28. Salo PM, Arbes SJ, Jr., Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol 2008; 121: 678- 84.e2.
  • 29. de Blay F, Sanchez J, Hedelin G, Perez-Infante A, Verot A, Chapman M, et al. Dust and airborne exposure to allergens derived from cockroach (Blattella germanica) in low-cost public housing in Strasbourg (France). J Allergy Clin Immunol 1997; 99: 107-12.
  • 30. Lewis SA, Weiss ST, Platts-Mills TA, Burge H, Gold DR. The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma. Am J Respir Crit Care Med 2002; 165: 961-6.
  • 31. Maas T, Rovers JJ, Schonberger HJ, Schayck CP. Distribution of house dust mite allergen: comparing house dust mite allergen levels in dust samples collected from different sites on living room floors with smooth coverings. Allergy 2003; 58: 500-2.
There are 31 citations in total.

Details

Other ID JA47KG74NV
Journal Section Research Article
Authors

Nimet Demirtaş This is me

Emel Ceylan This is me

Sevin Kırdar This is me

Fisun Karadağ This is me

Orhan Çildağ This is me

Publication Date December 1, 2016
Published in Issue Year 2016 Volume: 17 Issue: 3

Cite

EndNote Demirtaş N, Ceylan E, Kırdar S, Karadağ F, Çildağ O (December 1, 2016) The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal 17 3 129–137.