BibTex RIS Cite

Erişkinlerde Görülen Nadir Bir Yumuşak Doku Tümörü: Hibernom Olgu Sunumu

Year 2016, Volume: 17 Issue: 3, 168 - 171, 01.12.2016

Abstract

Hibernom, fetal kahverengi yağ doku kalıntılarından ortaya çıkan, seyrek görülen, kahverengi yağ doku tümörüdür. Genellikle erişkinlerde görülen, geniş, asidofilik, granüler ve vakuoler sitoplazmalı, santral nükleuslara sahip hücrelerden meydana gelmiş, kapsüllü, sarı-kahverengi, ağrısız ve benign yumuşak doku tümörüdür. Olgumuz 31 yaşında, boynunda şişlik şikayeti olan erkek hastadır. Yapılan görüntülemeler sonucu lezyonun lipom ile uyumlu olduğu bildirilmiştir. Eksizyon sonrası makroskopik olarak kahverengi, yer yer kirli sarı renkli yağ doku görünümünde, kesit yüzleri kahverengi ve hemorajik materyaller izlenmiştir. Mikroskopik incelemede vakuollü, granüler ve eozinofilik sitoplazmalı, yer yer santral yer yer periferik yerleşimli küçük, yuvarlak nükleuslu hücrelerden oluşan tümör gözlenmiştir. Uygulanan histokimyasal Oil-Red-O ile bu hücreler boyanmış ve lipositlerle uyumlu olarak değerlendirilmiştir. Bu bulgularla hastaya hibernom tanısı konulmuştur. Histopatolojik olarak, hibernom, granüler hücreli miyoblastom, yuvarlak hücreli liposarkom, lipoblastomatozis, sebase adenom, pleomorfik lipom ve kahverengi yağın normal birikimlerinden ayırt edilmelidir. Tedavide tümörün total eksizyonu yeterlidir. Bu olgu, nadir görülmesi, basit eksizyonla tedavi edilebilmesi ve özellikle yüksek damarlanma gösteren lezyonların ayırıcı tanısında akılda tutulması gerektiği için sunulmaya değer bulunmuştur

References

  • 1. Guidry CA, McGahren ED, Rodgers BM, Kane BJ. Pediatric cervicomediastinal hibernoma: a case report. J Pediatr Surg 2013; 48: 258-61.
  • 2. Dagher W, Fedore L, Wein RO. Hibernoma presenting as an asymptomatic neck mass. Am J Otolaryngol 2013; 34: 755-6.
  • 3. Mavrogenis AF, Coll-Mesa L, Drago G, Gambarotti M, Ruggieri P. Hibernomas: clinicopathological features, diagnosis, and treatment of 17 cases. Orthopedics 2011; 34: e755-9.
  • 4. Gery L, Bonnel MF. Discussion du Tumeur du Creux de l’Aisselle. Bull Men Soc Anat (Paris) 1914; 89: 110–2.
  • 5. Ökten T, Kandemir O. Kahverenkli Yağ Dokusunun Benign Tümörü: Hibernom. Türk Patoloji Dergisi 1991; 7: 55-6.
  • 6. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR. Hibernoma-correlation of histopathology and magneticresonance-imaging features in 10 cases. Skeletal Radiol 2006; 35: 579-89.
  • 7. Santambrogio L, Cioffi U, De Simone M, Nosotti M, Pavoni G, Caputo V, et al. Cervicomediastinal hibernoma. Ann Thorac Surg 1997; 64: 1160-2.
  • 8. Lele SM, Chundru S, Chaljub G, Adegboyega P, Haque AK. Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med 2002; 126: 975-8.
  • 9. Gaffney EF, Hargreaves HK, Semple E, Vellios F. Hibernoma: distinctive light and electron microscopic features and relationship to brown adipose tissue. Hum Pathol 1983; 14: 677- 87.
  • 10. Peycru T, Tardat E, Schwartz A, Dufau JP, Benois A, Durand-Dastes F. Hibernoma of the neck: a rare benign tumour. Can J Surg 2009; 52: E52-3.
  • 11. Biliński PJ, Junk S, Szukalski J. Hibernoma in a 13-year-old boy. Med Pediatr Oncol 2000; 35: 436-7.
  • 12. Stanford University, Faculty of Medicine, Surgical Pathology Criteria, Hibernoma. 2014, Available from: URL: http:// surgpathcriteria.stanford.edu/softfat/hibernoma/ differentialdiagnosis.html
  • 13. Teplitz C, Farrugia R, Glicksman AS. Malignant hibernoma does exist [abstract]. Lab Invest 1980; 42: 154–5.

A Rare Soft Tissue Tumor in Adults: Hibernoma a Case Report

Year 2016, Volume: 17 Issue: 3, 168 - 171, 01.12.2016

Abstract

Hibernoma is a rare lipomatous tumor of brown fat origin that emerges from remnants of fetal brown adipose tissue. They are encapsulated, yellow- tan colored, painless and benign soft tissue tumors, usually seen in adults and occur with large cells that have acidophilic, granular and vacuolar cytoplasm and central nuclei. Our case is a 31-year-old male who had swelling in the neck. Imaging studies depicted a lesion compatible with lipoma. Macroscopic evaluation of the excision specimen revealed brown, tan-yellow colored and haemorrhagic cut surface compatible with fat tissue. In microscopic examination, a tumor composed of cells with vacuolar, granular and eosinophilic cytoplasm, centrally or peripherally localized small, round nuclei, were observed. These cells were stained with histochemical Oil-Red-O and were evaluated to be comparable with lipocytes. With these findings, the patient was diagnosed as having hibernoma. Histopathologically, hibernoma must be distinguished from granular cell myoblastoma, round cell liposarcoma, lipoblastomatosis, sebaceous adenoma, pleomorphic lipoma and normal brown fat accumulation. Total excision of the tumor is sufficient. We present this case for its rarity, and for the fact that it can be treated with simple excision, and should be kept in mind especially in the differential diagnosis of lesions with high vascularity.

References

  • 1. Guidry CA, McGahren ED, Rodgers BM, Kane BJ. Pediatric cervicomediastinal hibernoma: a case report. J Pediatr Surg 2013; 48: 258-61.
  • 2. Dagher W, Fedore L, Wein RO. Hibernoma presenting as an asymptomatic neck mass. Am J Otolaryngol 2013; 34: 755-6.
  • 3. Mavrogenis AF, Coll-Mesa L, Drago G, Gambarotti M, Ruggieri P. Hibernomas: clinicopathological features, diagnosis, and treatment of 17 cases. Orthopedics 2011; 34: e755-9.
  • 4. Gery L, Bonnel MF. Discussion du Tumeur du Creux de l’Aisselle. Bull Men Soc Anat (Paris) 1914; 89: 110–2.
  • 5. Ökten T, Kandemir O. Kahverenkli Yağ Dokusunun Benign Tümörü: Hibernom. Türk Patoloji Dergisi 1991; 7: 55-6.
  • 6. Ritchie DA, Aniq H, Davies AM, Mangham DC, Helliwell TR. Hibernoma-correlation of histopathology and magneticresonance-imaging features in 10 cases. Skeletal Radiol 2006; 35: 579-89.
  • 7. Santambrogio L, Cioffi U, De Simone M, Nosotti M, Pavoni G, Caputo V, et al. Cervicomediastinal hibernoma. Ann Thorac Surg 1997; 64: 1160-2.
  • 8. Lele SM, Chundru S, Chaljub G, Adegboyega P, Haque AK. Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med 2002; 126: 975-8.
  • 9. Gaffney EF, Hargreaves HK, Semple E, Vellios F. Hibernoma: distinctive light and electron microscopic features and relationship to brown adipose tissue. Hum Pathol 1983; 14: 677- 87.
  • 10. Peycru T, Tardat E, Schwartz A, Dufau JP, Benois A, Durand-Dastes F. Hibernoma of the neck: a rare benign tumour. Can J Surg 2009; 52: E52-3.
  • 11. Biliński PJ, Junk S, Szukalski J. Hibernoma in a 13-year-old boy. Med Pediatr Oncol 2000; 35: 436-7.
  • 12. Stanford University, Faculty of Medicine, Surgical Pathology Criteria, Hibernoma. 2014, Available from: URL: http:// surgpathcriteria.stanford.edu/softfat/hibernoma/ differentialdiagnosis.html
  • 13. Teplitz C, Farrugia R, Glicksman AS. Malignant hibernoma does exist [abstract]. Lab Invest 1980; 42: 154–5.
There are 13 citations in total.

Details

Other ID JA52SE64KJ
Journal Section Case Report
Authors

Tuğba Özbek This is me

Canten Tataroğlu This is me

Özlem Erdal Özdemir This is me

Ayşe Gül Örmeci This is me

Ceren Günel This is me

Publication Date December 1, 2016
Published in Issue Year 2016 Volume: 17 Issue: 3

Cite

EndNote Özbek T, Tataroğlu C, Özdemir ÖE, Örmeci AG, Günel C (December 1, 2016) A Rare Soft Tissue Tumor in Adults: Hibernoma a Case Report. Meandros Medical And Dental Journal 17 3 168–171.