Factors Affecting Arterial Stiffness Level in Cancer Patients Receiving Immunotherapy

Year 2025, Volume: 26 Issue: 1, 101 - 107, 20.03.2025

Esra Güner , Merve Bıyıklı Alemdar , Bilgin Demir , Merve Turan , Esin Oktay

https://doi.org/10.69601/meandrosmdj.1594499

Abstract

Aim: This study aimed of our study is to investigate the factors affecting the level of arterial stiffness in cancer patients receiving immunotherapy.
Materials and Methods: The height, weight, BMI, age, gender, type of cancer, previous cancer treatment, agents used in the treatment, current immunotherapy agents, comorbid conditions, smoking history of 42 patients diagnosed with renal cell carcinoma (RCC), lung cancer, malignant melanoma and receiving immunotherapy treatment were recorded at the time of their first application and their arterial stiffness levels were measured. Following the first measurement, the patients were seen again in the third and sixth therapy cycles and their measurements were repeated and recorded. Factors affecting the arterial stiffness level of the patients were evaluated.
Results: It was observed that pulse wave velocity (NWV) increased with increasing age (p<0.01). No significant difference was found between cancer type and PWV; however, patients with lung cancer had higher pulse pressure at the first measurement than other patients. No significant difference was found between immunotherapy agents and PWV. PWV was found to be significantly higher in those with concomitant diseases (p<0.005). Pulse pressure was found to be higher in smokers than in non-smokers (p<0.007).
Conclusion: It was concluded that smoking, gender and cancer type were effective in the change of pulse pressure in cancer patients receiving immunotherapy, that there was no significant difference in other factors; PWV increased with age; and that PWV was higher in those with additional diseases.

Keywords

Arterial stiffness, immunotherapy, cancer

Immünoterapi Alan Kanser Hastalarinda Arteriyel Sertlik Seviyesini Etkileyen Faktörler

Abstract

Amaç: Bu çalışmanın amacı, immünoterapi alan kanser hastalarında arteriyel sertlik düzeyini etkileyen faktörleri araştırmaktır.
Gereç ve Yöntemler: Renal hücreli karsinom (RCC), akciğer kanseri, malign melanom tanısı almış ve immünoterapi tedavisi gören 42 hastanın boyu, kilosu, VKİ'si, yaşı, cinsiyeti, kanser türü, daha önce kanser tedavisi görmesi, tedavide kullanılan ajanlar, mevcut immünoterapi ajanları, eşlik eden hastalıkları, sigara içme öyküsü ilk başvuru anında kaydedildi ve arteriyel sertlik düzeyleri ölçüldü. İlk ölçümün ardından hastalar üçüncü ve altıncı tedavi sikluslarında tekrar görüldü ve ölçümleri tekrarlanarak kaydedildi. Hastaların arteriyel sertlik düzeyini etkileyen faktörler değerlendirildi.
Bulgular: Nabız dalga hızının (NWV) artan yaşla birlikte arttığı görüldü (p<0.01). Kanser türü ile PWV arasında anlamlı bir fark bulunmadı; ancak akciğer kanserli hastaların ilk ölçümde diğer hastalara göre daha yüksek nabız basıncı vardı. İmmünoterapi ajanları ile PWV arasında anlamlı bir fark bulunmadı. Eşlik eden hastalıkları olanlarda PWV anlamlı olarak daha yüksek bulundu (p<0.005). Nabız basıncı sigara içenlerde sigara içmeyenlere göre daha yüksek bulundu (p<0.007).
Sonuç: İmmünoterapi alan kanser hastalarında nabız basıncının değişiminde sigara içmenin, cinsiyetin ve kanser tipinin etkili olduğu, diğer faktörlerde anlamlı bir fark olmadığı, PWV'nin yaşla arttığı ve ek hastalıkları olanlarda PWV'nin daha yüksek olduğu sonucuna varıldı.

Keywords

Arteriyel sertlik, immünoterapi, kanser

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