Root Dentin Remineralization by Arginine and Sodium Fluoride

Year 2023, Volume: 24 Issue: 2, 125 - 130, 30.06.2023

Selver Suna Başak , Funda Bayındır , Eda Dokumacıoğlu

Abstract

Objective: The aim of this study was to investigate the possible effects of arginine and sodium fluoride on the microhardness of demineralized root dentin.
Materials and Methods: Forty anterior teeth were collected. Disc specimens with 2 mm thickness were prepared. Specimens were divided into 4 groups (10 specimens/group). Microhardness measurements and scanning electron microscopy/energy dispersive X-ray spectrometry analysis were performed before and after the treatment. Statistical analyses were conducted with the software SPSS 19.0.
Results: There was a significant difference between mean values of microhardness (p<0.05). There were statistically significant differences among the groups in terms of phosphorus (p<0.05) while the difference in calcium was not statistically significant (p>0.05).
Conclusion: No effects on microhardness and remineralization were observed by arginine application

Keywords

Arginine , dental caries , energy dispersive X-ray spectroscopy , fluoride , microhardness , scanning electron microscopy

References

• 1. Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of untreated caries: a systematic review and metaregression. J Dent Res 2015; 94: 650-8.
• 2. Fontana M. Enhancing Fluoride: Clinical Human Studies of Alternatives or Boosters for Caries Management. Caries Res 2016; 50 Suppl 1: 22-37.
• 3. Altan H, Göztaş Z, Kahraman K, Kuş M, Tosun G. Inhibition Effects of Different Toothpastes on Demineralisation of Incipient Enamel Lesions. Oral Health Prev Dent 2019; 17: 179-85.
• 4. Arifa MK, Ephraim R, Rajamani T. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent 2019; 12: 139-44.
• 5. Amaechi BT, AbdulAzees PA, Alshareif DO, Shehata MA, Lima PPCS, Abdollahi A, et al. Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children. BDJ Open 2019; 5: 18.
• 6. Anderson CJ, Kugel G, Zou Y, Ferrari M, Gerlach R. A randomized, controlled, two-month pilot trial of stannous fluoride dentifrice versus sodium fluoride dentifrice after oxalate treatment for dentinal hypersensitivity. Clin Oral Investig 2020; 24: 4043-9.
• 7. Erdemir U, Yıldız E. Diagnosis and Treatment Planning of Dentinal Hypersensitivity. EU Dishek Fak Derg 2011; 32: 9-22.
• 8. Osmari D, Fraga S, Ferreira ACO, Eduardo CP, Marquezan M, Silveira BLD. In-office Treatments for Dentin Hypersensitivity: A Randomized Split-mouth Clinical Trial. Oral Health Prev Dent 2018; 16: 125-30.
• 9. Ritter AV, de L Dias W, Miguez P, Caplan DJ, Swift EJ Jr. Treating cervical dentin hypersensitivity with fluoride varnish: a randomized clinical study. J Am Dent Assoc 2006; 137: 1013-20; quiz 9.
• 10. Souza ML, Cury JA, Tenuta LM, Zhang YP, Mateo LR, Cummins D, et al. Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. J Dent 2013; 41 Suppl 2: S35-41.
• 11. Ástvaldsdóttir Á, Naimi-Akbar A, Davidson T, Brolund A, Lintamo L, Attergren Granath A, et al. Arginine and Caries Prevention: A Systematic Review. Caries Res 2016; 50: 383-93.
• 12. Yu OY, Mei ML, Zhao IS, Li QL, Lo EC, Chu CH. Remineralisation of enamel with silver diamine fluoride and sodium fluoride. Dent Mater 2018; 34: e344-52.
• 13. Ten Cate JM, Larsen MJ, Pearce EIF, Fejerskov O. Chemical interactions between the tooth and oral fluid.s (8th ed.). Copenhagen, Denmark: Blackwell Munksgaard, 2003.
• 14. Rafael CF, Quinelato V, Morsch CS, DeDeus G, Reis CM. Morphological Analysis of Dentin Surface after Conditioning with Two Different methods: Chemical and Mechanical. J Contemp Dent Pract 2016; 17: 58-62.
• 15. Alsubhi H, Gabbani M, Alsolami A, Alosaimi M, Abuljadayel J, Taju W, et al. A Comparison between Two Different Remineralizing Agents against White Spot Lesions: An In Vitro Study. Int J Dent 2021; 2021: 6644069.
• 16. Konagala RK, Mandava J, Anwarullah A, Uppalapati LV, Karumuri S, Angadala PL. Synergistic Effect of Arginine on Remineralization Potential of Fluoride Varnish and Nanohydroxyapatite on Artificial Caries Lesions: An In Vitro Study. J Contemp Dent Pract 2020; 21: 1048-53.
• 17. Bijle MN, Abdalla MM, Ashraf U, Ekambaram M, Yiu CKY. Enamel remineralization potential of arginine-fluoride varnish in a multispecies bacterial pH-cycling model. J Dent 2021; 104: 103528.
• 18. Butera A, Pascadopoli M, Gallo S, Lelli M, Tarterini F, Giglia F, et al. SEM/EDS Evaluation of the Mineral Deposition on a Polymeric Composite Resin of a Toothpaste Containing Biomimetic ZnCarbonate Hydroxyapatite (microRepair®) in Oral Environment: A Randomized Clinical Trial. Polymers (Basel) 2021; 13: 2740.
• 19. Arnold WH, Heidt BA, Kuntz S, Naumova EA. Effects of fluoridated milk on root dentin remineralization. PLoS One 2014; 9: e104327. Erratum in: PLoS One 2014; 9: e108199.
• 20. Chuenarrom, Benjakul P, Daosodsai P. Effect of indentation load and time on knoop and vickers microhardness tests for enamel and dentin. Materials Research 2009; 12: 473-6.
• 21. Reis DP, Filho JDN, Rossi AL, de Almeida Neves A, Portela MB, da Silva EM. Remineralizing potential of dental composites containing silanized silica-hydroxyapatite (Si-HAp) nanoporous particles charged with sodium fluoride (NaF). J Dent 2019; 90: 103211.
• 22. Rosin-Grget K, Lincir I, Tudja M. Effect of amine fluoride on enamel surface morphology. Coll Antropol 2000; 24: 501-8.
• 23. Hsua HC, Lee SS, Chang YC. Clinical efficacy of toothpaste containing 8.0% arginine and calcium carbonate for teeth hypersensitivity. Journal of Dental Sciences 2013; 8: 444-7.
• 24. Que K, Fu Y, Lin L, Hu D, Zhang YP, Panagakos FS, et al. Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults. Am J Dent 2010; 23: 28A-35.