Oxyhemoglobin Dissociation Curve in COVID-19 Patients

Year 2023, Volume: 24 Issue: 3, 258 - 261, 30.09.2023

Hilal Üstündağ , Cuma Mertoğlu , Mehmet Tahir Huyut

Abstract

• The sentences under the heading Abstract and Öz onpage 58 have been changed.

- Incorrect
Results: It was concluded that patients with COVID-19 and other respiratory distress patients had a slight right-leaning trend in the ODC compared with the standard curve. The P50 value of the ICU group was higher than the other groups (mean: 30.74 mmHg, n=131, p=0.047). While the percentage of oxyhemoglobin (mean: 65.44% vs 69.81%, p=0.015), the amount of glucose (mean: 163.39 mg/dL vs 195.36 mg/dL, p=0.002) and pH (median: 7.38 vs 7.41, p=0.007) in the nonICU group was higher compared with the control group, the carboxyhemoglobin percentage (mean: 1.66% vs 1.13%, p=0.000), PCO2 (42.02 mmHg vs 39.44 mmHg, p=0.015), potassium (mean: 4.33 mmol/L vs 4.04, p=0.026), and sodium (mean: 138.10 mmol/L vs 135.80 mmol/L, p=0.000) were lower. The methemoglobin percentage of the ICU group was lower (p=0.000) than the other groups. Bulgular: COVID-19 tanılı ve diğer solunum sıkıntılı hastaların ODC’lerinin standart eğriye göre hafif sağa eğilim gösterdiği belirlendi. YBÜ grubunun P50 değeri, diğer gruplara kıyasla daha yüksekti (ortalama: 30,74 mmHg, n=131, p=0,047). Kontrole kıyasla non-YBÜ grubunun; oksihemoglobin yüzdesi (ortalama: %65,44 vs %69,81, p=0,015), PO2 ’ı (46,98 mmHg vs 48,98 mmHg, p=0,001), glikoz miktarı (ortalama: 163,39 mg/dL vs 195,36 mg/dL, p=0,002) ve pH’sı (medyan: 7,38 vs 7,41, p=0,007) daha yüksek iken karboksihemoglobin yüzdesi (ortalama: %1,66 vs %1,13, p=0,000), PCO2 ’ı (42,02 mmHg vs 39,44 mmHg, p=0,015), potasyum (ortalama: 4,33 mmol/L vs 4,04, p=0,026) ve sodyum (ortalama: 138,10 mmol/L vs 135,80 mmol/L, p=0,000) seviyesi daha düşüktü. YBÜ grubunun methemoglobin yüzdesi ise diğer gruplara kıyasla daha düşüktü (p=0,000).

- Corrected
Results: It was concluded that patients with COVID-19 and other respiratory distress patients had a slight rightleaning trend in the ODC compared with the standard curve. The P50 value of the ICU group was higher than the other groups (mean: 30.74 mmHg, n=131, p=0.047). While the percentage of oxyhemoglobin (mean: 65.44% vs 69.81%, p=0.015), PO2 (46.98 mmHg vs 48.98 mmHg, p<0.001), the amount of glucose (mean: 163.39 mg/dL vs 195.36 mg/dL, p=0.002) and pH (median: 7.38 vs 7.41, p=0.007) in the nonICU group was higher compared with the control group, the carboxyhemoglobin percentage (mean: 1.66% vs 1.13%, p<0.001), PCO2 (42.02 mmHg vs 39.44 mmHg, p=0.015), potassium (mean: 4.33 mmol/L vs 4.04, p=0.026), and sodium (mean: 138.10 mmol/L vs 135.80 mmol/L, p<0.001) were lower. The methemoglobin percentage of the ICU group was lower (p<0.001) than the other groups. Bulgular: COVID-19 tanılı ve diğer solunum sıkıntılı hastaların ODC’lerinin standart eğriye göre hafif sağa eğilim gösterdiği belirlendi. YBÜ grubunun P50 değeri, diğer gruplara kıyasla daha yüksekti (ortalama: 30,74 mmHg, n=131, p=0,047). Kontrole kıyasla non-YBÜ grubunun; oksihemoglobin yüzdesi (ortalama: %65,44 vs %69,81, p=0,015), PO2 (46,98 mmHg vs 48,98 mmHg, p<0,001), glikoz miktarı (ortalama: 163,39 mg/dL vs 195,36 mg/dL, p=0,002) ve pH’si (medyan: 7,38 vs 7,41, p=0,007) daha yüksek iken karboksihemoglobin yüzdesi (ortalama: %1,66 vs %1,13, p<0,001), PCO2 ’ı (42,02 mmHg vs 39,44 mmHg, p=0,015), potasyum (ortalama: 4,33 mmol/L vs 4,04, p=0,026) ve sodyum (ortalama: 138,10 mmol/L vs 135,80 mmol/L, p<0,001) seviyesi daha düşüktü. YBÜ grubunun methemoglobin yüzdesi ise diğer gruplara kıyasla daha düşüktü (p<0,001).

• A sentence has been changed under the title of Statistical Analysis on page 59, 11th line.
- Incorrect Tukey and Dunnett post-hoc tests determined significant changes’ sources.
- Corrected Tukey HSD or Games-Howell post-hoc tests were employed to assess differences between groups following one-way ANOVA analysis, while Dunn’s post-hoc test was utilized to assess differences between groups after Kruskal-Wallis analysis.

• The p=0.000 values in the p-values column in Table 1 on page 60 of the related article have been changed to p=0.001.

Keywords

COVID-19, hematological parameters, oxygen affinity, SARS-CoV-2