Glycated Albumin and Hba1c for the Diagnosis of Prediabetes in Obeseand Non-obese Individuals

Year 2023, Volume: 24 Issue: 4, 327 - 333, 30.12.2023

Rovshan Abbasov Pervin Demir Almila Şenat , Tuba Çandar , Reyhan Ersoy , Leyla Didem Kozacı

Abstract

Objective: In our study, we examined whether glycated albumin (GA) had any superiority overthe HbA1c test in detecting individualswith insulin resistance, prediabetes, and diabetes in obese and non-obese groups. This study is the first to examine the diagnosticpower of HbA1c and GA tests alone ortogether for prediabetes, diabetes, and insulin resistance in non-obese and obese individuals.
Materials and Methods: The study was conducted at Ankara Yıldırım Beyazıt University Faculty of Medicine and Atatürk Trainingand Research Hospital. Individuals were divided into three groups: diabetes, prediabetes, and insulin resistance, which were furthersub-grouped as obese and non-obese according to their body mass index values.
Results: When we examined the HbA1c and GA values in the diabetes, prediabetes, and insulin resistance groups, we foundsignificantly higherrates of correct detection of prediabetes and diabetes (sensitivity) forGAthan forHbA1c in non-obese individuals. The specificity of GA was lower than HbA1c in these non-obese individuals, whereas the specificity of GA was similar to HbA1cinobese individuals. Our data show that in non-obese individuals, GA measurement is a more sensitive but less specific tool comparedwith the measurement of HbA1c. Therefore, we suggest that, while HbA1c and GA were in agreement with oral glucose tolerancetest and fasting glucose levels in the diagnosis of diabetes in obese individuals (p<0.05), GA alone or together with HbA1c maybeavaluable tool in the diagnosis of prediabetes and diabetes in non-obese individuals.
Conclusion: This study shows that GA levels have higher sensitivity and lower specificity than HbA1c in the diagnosis of type2diabetes in non-obese individuals.

Keywords

Prediabetes, diabetes mellitus, glycated albumin, HbA1c

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