Research Article
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Year 2021, Volume: 22 Issue: 2, 187 - 195, 31.08.2021
https://doi.org/10.4274/meandros.galenos.2021.53824

Abstract

References

  • 1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-94.
  • 2. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7: 270-9.
  • 3. Gallassi R, Oppi F, Poda R, Scortichini S, Stanzani Maserati M, Marano G, et al. Are subjective cognitive complaints a risk factor for dementia? Neurol Sci 2010; 31: 327-36.
  • 4. Nordlund A, Rolstad S, Klang O, Edman A, Hansen S, Wallin A. Two-year outcome of MCI subtypes and aetiologies in the Göteborg MCI study. J Neurol Neurosurg Psychiatry 2010; 81: 541-6.
  • 5. Ganguli M, Snitz BE, Saxton JA, Chang CC, Lee CW, Vander Bilt J, et al. Outcomes of mild cognitive impairment by definition: a population study. Arch Neurol 2011; 68: 761-7.
  • 6. Ganguli M, Dodge HH, Shen C, DeKosky ST. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology 2004; 63: 115-21.
  • 7. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği \[Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg 2002; 13: 273-81.
  • 8. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566-72.
  • 9. Karakaş S, Eski R, Başar E. Türk kültürü için standardizasyonu yapılmış nöropsikolojik testler topluluğu: BİLNOT Bataryası. 32. Ulusal Nöroloji Kongresi kitabı. İstanbul; 1996. p. 43-70.
  • 10. Öktem Ö. Nöropsikolojik testler ve nöropsikolojik değerlendirme. Türk Psikoloji Dergisi 1994; 9:33-44.
  • 11. Tumaç A. Normal deneklerde frontal hasarlara duyarlı bazı testlerde performansa yaş ve eğitimin etkisi. İstanbul Üniversitesi Sosyal Bilimler Enstitüsü Psikoloji Bölümü, Yüksek Lisans Tezi, İstanbul. 1997.
  • 12. Karakaş S. Bilnot Bataryası El Kitabı: Nöropsikolojik Testler için Araştırma ve Geliştirme Çalışmaları Dizayn Ofset, Ankara: 2004.
  • 13. Sezgin N, Baştuğ G, Karaağaç Yargıcı S, Yılmaz B. Wechsler Yetişkinler İçin Zekâ Ölçeği Gözden Geçirilmiş Formu (WAIS-R) Türkiye Standardizasyonu: Ön Çalışma. Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 2014; 54: 451-80.
  • 14. Öktem Ö. Sözel Bellek Süreçleri Testi (SBST) – Bir Ön Çalışma. Nöropsikiyatri Arşivi 1992; 29: 196-206.
  • 15. Keskinkılıç C. Standardization of Benton Face Recognition Test in a Turkish Normal Adult Population. Turk J Neurol 2008; 14: 179-90.
  • 16. Kurt M, Can H, Karakaş S. Boston Adlandırma Testi Türk Formu İçin Araştırma-Geliştirme Çalışması. Yeni Symposium 2016; 54: 6-14.
  • 17. Shulman KI, Shedletsky R, Silver IL. The challenge of time: Clock-drawing and cognitive function in the elderly. Int J Geriatr Psychiatr 1986; 1: 135-40.
  • 18. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği \[Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg 2002; 13: 273-81.
  • 19. Cornelis E, Gorus E, Beyer I, Bautmans I, De Vriendt P. Early diagnosis of mild cognitive impairment and mild dementia through basic and instrumental activities of daily living: Development of a new evaluation tool. PLoS Med 2017; 14: e1002250.
  • 20. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer’s disease: an independent component analysis. J Neurosci 2006; 26: 10222-31.
  • 21. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron 2009; 62: 42-52.
  • 22. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004; 256: 240-6.
  • 23. Tang-Wai DF, Knopman DS, Geda YE, Edland SD, Smith GE, Ivnik RJ, et al. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol 2003; 60: 1777-83.
  • 24. Standish TI, Molloy DW, Cunje A, Lewis DL. Do the ABCS 135 short cognitive screen and its subtests discriminate between normal cognition, mild cognitive impairment and dementia? Int J Geriatr Psychiatry 2007; 22: 189-94.
  • 25. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
  • 26. Holsinger T, Deveau J, Boustani M, Williams JW Jr. Does this patient have dementia? JAMA 2007; 297: 2391-404.
  • 27. Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health 2020; 5: 661-71.
  • 28. Lopez OL, Becker JT, Chang YF, Sweet RA, DeKosky ST, Gach MH, et al. Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. Neurology 2012; 79: 1599-606.
  • 29. Galasko D, Edland SD, Morris JC, Clark C, Mohs R, Koss E. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part XI. Clinical milestones in patients with Alzheimer’s disease followed over 3 years. Neurology 1995; 45: 1451-5.
  • 30. Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, et al. Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology 2010; 74: 201-9.
  • 31. Ashendorf L, Jefferson AL, O’Connor MK, Chaisson C, Green RC, Stern RA. Trail Making Test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol 2008; 23: 129-37.
  • 32. Chen NC, Chang CC, Lin KN, Huang CW, Chang WN, Chang YT, et al. Patterns of executive dysfunction in amnestic mild cognitive impairment. Int Psychogeriatr 2013; 25: 1181-9.
  • 33. Weakley A, Schmitter-Edgecombe M, Anderson J. Analysis of verbal fluency ability in amnestic and non-amnestic mild cognitive impairment. Arch Clin Neuropsychol 2013; 28: 721-31.
  • 34. Yagi T, Ito D, Sugiyama D, Iwasawa S, Tabuchi H, Konishi M, et al. Diagnostic accuracy of neuropsychological tests for classification of dementia. Neurology Asia 2016; 21: 47-54.
  • 35. Shulman KI. Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry 2000; 15: 548-61.
  • 36. Mendez MF, Ala T, Underwood KL. Development of scoring criteria for the clock drawing task in Alzheimer’s disease. J Am Geriatr Soc 1992; 40: 1095-9.
  • 37. Royall DR, Cordes JA, Polk M. CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry 1998; 64: 588-94.
  • 38. Umidi S, Trimarchi PD, Corsi M, Luzzati C, Annoni G. Clock drawing test (CDT) in the screening of mild cognitive impairment (MCI). Arch Gerontol Geriatr 2009; 49: 227-9.
  • 39. Beber BC, Kochhann R, Matias B, Chaves MLF. The Clock Drawing Test: Performance differences between the free-drawn and incomplete-copy versions in patients with MCI and dementia. Dement Neuropsychol 2016; 10: 227-31.

Differentiating Mild Forms of Cognitive Impairment and Dementia: Where Other Tests Fail, Verbal Memory Assessment May Prove Critical

Year 2021, Volume: 22 Issue: 2, 187 - 195, 31.08.2021
https://doi.org/10.4274/meandros.galenos.2021.53824

Abstract

Objective: Mild cognitive impairment (MCI) and mild dementia are common. In both cases, objective symptoms of cognitive impairment are present; as such, diagnosis is based on patient history and cognitive examination. This study aimed to investigate the role of neurocognitive tests in the discrimination of these disorders, by comparing mild dementia with MCI.
Materials and Methods: A battery of neurocognitive tests were applied to patients admitted to the neurology and psychiatry clinics with diagnoses of MCI (n=30) or Alzheimer-type dementia (mild, n=23; moderate, n=19).
Results: The three groups demonstrated significant differences in the neurocognitive tests, but the mild dementia and MCI groups almost always had similar results. Only the Öktem verbal memory processes test showed significantly different results in the comparison of MCI and mild dementia, with better scores in the MCI group than in the mild dementia group in terms of total learning and delayed free recall subtests (p=0.023 and p=0.001).
Conclusion: The short-term memory recall (total learning) and long-term memory recall (delayed free recall) subtests of the verbal memory processes test can guide in the discrimination of MCI from mild dementia.

References

  • 1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-94.
  • 2. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7: 270-9.
  • 3. Gallassi R, Oppi F, Poda R, Scortichini S, Stanzani Maserati M, Marano G, et al. Are subjective cognitive complaints a risk factor for dementia? Neurol Sci 2010; 31: 327-36.
  • 4. Nordlund A, Rolstad S, Klang O, Edman A, Hansen S, Wallin A. Two-year outcome of MCI subtypes and aetiologies in the Göteborg MCI study. J Neurol Neurosurg Psychiatry 2010; 81: 541-6.
  • 5. Ganguli M, Snitz BE, Saxton JA, Chang CC, Lee CW, Vander Bilt J, et al. Outcomes of mild cognitive impairment by definition: a population study. Arch Neurol 2011; 68: 761-7.
  • 6. Ganguli M, Dodge HH, Shen C, DeKosky ST. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology 2004; 63: 115-21.
  • 7. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği \[Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg 2002; 13: 273-81.
  • 8. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566-72.
  • 9. Karakaş S, Eski R, Başar E. Türk kültürü için standardizasyonu yapılmış nöropsikolojik testler topluluğu: BİLNOT Bataryası. 32. Ulusal Nöroloji Kongresi kitabı. İstanbul; 1996. p. 43-70.
  • 10. Öktem Ö. Nöropsikolojik testler ve nöropsikolojik değerlendirme. Türk Psikoloji Dergisi 1994; 9:33-44.
  • 11. Tumaç A. Normal deneklerde frontal hasarlara duyarlı bazı testlerde performansa yaş ve eğitimin etkisi. İstanbul Üniversitesi Sosyal Bilimler Enstitüsü Psikoloji Bölümü, Yüksek Lisans Tezi, İstanbul. 1997.
  • 12. Karakaş S. Bilnot Bataryası El Kitabı: Nöropsikolojik Testler için Araştırma ve Geliştirme Çalışmaları Dizayn Ofset, Ankara: 2004.
  • 13. Sezgin N, Baştuğ G, Karaağaç Yargıcı S, Yılmaz B. Wechsler Yetişkinler İçin Zekâ Ölçeği Gözden Geçirilmiş Formu (WAIS-R) Türkiye Standardizasyonu: Ön Çalışma. Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 2014; 54: 451-80.
  • 14. Öktem Ö. Sözel Bellek Süreçleri Testi (SBST) – Bir Ön Çalışma. Nöropsikiyatri Arşivi 1992; 29: 196-206.
  • 15. Keskinkılıç C. Standardization of Benton Face Recognition Test in a Turkish Normal Adult Population. Turk J Neurol 2008; 14: 179-90.
  • 16. Kurt M, Can H, Karakaş S. Boston Adlandırma Testi Türk Formu İçin Araştırma-Geliştirme Çalışması. Yeni Symposium 2016; 54: 6-14.
  • 17. Shulman KI, Shedletsky R, Silver IL. The challenge of time: Clock-drawing and cognitive function in the elderly. Int J Geriatr Psychiatr 1986; 1: 135-40.
  • 18. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği \[Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg 2002; 13: 273-81.
  • 19. Cornelis E, Gorus E, Beyer I, Bautmans I, De Vriendt P. Early diagnosis of mild cognitive impairment and mild dementia through basic and instrumental activities of daily living: Development of a new evaluation tool. PLoS Med 2017; 14: e1002250.
  • 20. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer’s disease: an independent component analysis. J Neurosci 2006; 26: 10222-31.
  • 21. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron 2009; 62: 42-52.
  • 22. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004; 256: 240-6.
  • 23. Tang-Wai DF, Knopman DS, Geda YE, Edland SD, Smith GE, Ivnik RJ, et al. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol 2003; 60: 1777-83.
  • 24. Standish TI, Molloy DW, Cunje A, Lewis DL. Do the ABCS 135 short cognitive screen and its subtests discriminate between normal cognition, mild cognitive impairment and dementia? Int J Geriatr Psychiatry 2007; 22: 189-94.
  • 25. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
  • 26. Holsinger T, Deveau J, Boustani M, Williams JW Jr. Does this patient have dementia? JAMA 2007; 297: 2391-404.
  • 27. Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health 2020; 5: 661-71.
  • 28. Lopez OL, Becker JT, Chang YF, Sweet RA, DeKosky ST, Gach MH, et al. Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. Neurology 2012; 79: 1599-606.
  • 29. Galasko D, Edland SD, Morris JC, Clark C, Mohs R, Koss E. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part XI. Clinical milestones in patients with Alzheimer’s disease followed over 3 years. Neurology 1995; 45: 1451-5.
  • 30. Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, et al. Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology 2010; 74: 201-9.
  • 31. Ashendorf L, Jefferson AL, O’Connor MK, Chaisson C, Green RC, Stern RA. Trail Making Test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol 2008; 23: 129-37.
  • 32. Chen NC, Chang CC, Lin KN, Huang CW, Chang WN, Chang YT, et al. Patterns of executive dysfunction in amnestic mild cognitive impairment. Int Psychogeriatr 2013; 25: 1181-9.
  • 33. Weakley A, Schmitter-Edgecombe M, Anderson J. Analysis of verbal fluency ability in amnestic and non-amnestic mild cognitive impairment. Arch Clin Neuropsychol 2013; 28: 721-31.
  • 34. Yagi T, Ito D, Sugiyama D, Iwasawa S, Tabuchi H, Konishi M, et al. Diagnostic accuracy of neuropsychological tests for classification of dementia. Neurology Asia 2016; 21: 47-54.
  • 35. Shulman KI. Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry 2000; 15: 548-61.
  • 36. Mendez MF, Ala T, Underwood KL. Development of scoring criteria for the clock drawing task in Alzheimer’s disease. J Am Geriatr Soc 1992; 40: 1095-9.
  • 37. Royall DR, Cordes JA, Polk M. CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry 1998; 64: 588-94.
  • 38. Umidi S, Trimarchi PD, Corsi M, Luzzati C, Annoni G. Clock drawing test (CDT) in the screening of mild cognitive impairment (MCI). Arch Gerontol Geriatr 2009; 49: 227-9.
  • 39. Beber BC, Kochhann R, Matias B, Chaves MLF. The Clock Drawing Test: Performance differences between the free-drawn and incomplete-copy versions in patients with MCI and dementia. Dement Neuropsychol 2016; 10: 227-31.
There are 39 citations in total.

Details

Primary Language English
Subjects Psychiatry, Neurology and Neuromuscular Diseases
Journal Section Research Article
Authors

Ahmet Şair

Yaşan Bilge Şair

Simel Ayar

Publication Date August 31, 2021
Published in Issue Year 2021 Volume: 22 Issue: 2

Cite

EndNote Şair A, Şair YB, Ayar S (August 1, 2021) Differentiating Mild Forms of Cognitive Impairment and Dementia: Where Other Tests Fail, Verbal Memory Assessment May Prove Critical. Meandros Medical And Dental Journal 22 2 187–195.