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Simüle İmmatür Apeksli Dişlerde Farklı İrrigasyon Aktivasyon Yöntemlerinin Ekstrüze İrrigasyon Solüsyonu Miktarı Üzerine Etkinliği

Year 2025, Volume: 26 Issue: 3, 263 - 270, 22.09.2025
https://doi.org/10.69601/meandrosmdj.1614135

Abstract

Amaç: Bu çalışmanın amacı, dört farklı final irrigasyon aktivasyon yönteminin—standart iğne irrigasyonu (SNI), pasif ultrasonik irrigasyon (PUI), EndoActivator (EA) ve EDDY—simüle immatür apeksli dişlerde irrigasyon solüsyonlarının apikal ekstrüzyonu üzerindeki nicel etkilerini değerlendirmektir.
Materyal ve yöntemler: Tek kanallı, tek köklü 60 diş ProTaper Next sisteminin X3 eğesine kadar genişletildi. İmmatür apeks simülasyonu için Gates Glidden frezleri (#1–#6) kullanılarak apikal çap 1,5 mm’de standartlaştırıldı. Kanallar sırasıyla %2 NaOCl, %17 EDTA ve distile su ile irrige edildi. Her bir diş, kök ucuna yerleştirilen 27G iğne aracılığıyla drenaja izin verecek şekilde bir Eppendorf tüp kapağına monte edildi. Tüpler NaOCl ile dolduruldu. Örnekler, irrigasyon aktivasyon yöntemine göre rastgele dört gruba ayrıldı (n=15): SNI, PUI, EA ve EDDY. Tüm gruplarda toplamda 6 ml %2 NaOCl, 3 dakika süreyle aktive edildi. Ekstrüze olan irrigasyon solüsyonu, insülin şırıngası ile toplandı ve mililitre cinsinden kaydedildi.
Verilerin dağılımı Kolmogorov-Smirnov testi ile değerlendirildi. İstatistiksel analiz Kruskal-Wallis testi kullanılarak gerçekleştirildi (p<0,05).
Bulgular: En yüksek irrigasyon solüsyonu ekstrüzyon ortalaması SNI ve PUI gruplarında gözlenirken, EA grubu diğer yöntemlere kıyasla daha düşük ekstrüzyon sergiledi. Bununla birlikte, ekstrüze irrigasyon solüsyonu hacmi açısından yöntemler arasında istatistiksel olarak anlamlı bir fark bulunmadı (p>0,05).
Sonuç: Bu çalışma, immatür apeksli dişlerde test edilen tüm irrigasyon aktivasyon yöntemlerinin apikal ekstrüzyon kontrolünde benzer performans gösterdiğini ortaya koymaktadır.

References

  • 1. Kaya-Büyükbayram I, Özalp Ş, Aytugar E, Aydemir S. Regenerative endodontic treatment of an infected immature dens invaginatus with the aid of cone-beam computed tomography. Case Rep Dent. 2014;2014:403045. Epub 20141030. doi: 10.1155/2014/403045. PubMed PMID: 25530890; PubMed Central PMCID: PMC4229997.
  • 2. Cehreli ZC, Isbitiren B, Sara S, Erbas G. Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series. J Endod. 2011;37(9):1327-30. Epub 20110713. doi: 10.1016/j.joen.2011.05.033. PubMed PMID: 21846559.
  • 3. Cehreli ZC, Sara S, Aksoy B. Revascularization of immature permanent incisors after severe extrusive luxation injury. J Can Dent Assoc. 2012;78:c4. PubMed PMID: 22322021.
  • 4. Trope M. Treatment of the immature tooth with a non-vital pulp and apical periodontitis. Dent Clin North Am. 2010;54(2):313-24. doi: 10.1016/j.cden.2009.12.006. PubMed PMID: 20433980.
  • 5. Sharma R, Kumar V, Logani A, Chawla A, Sharma S, Koli B. Effect of Gravity on Periapical Extrusion of Irrigating Solution With Different Irrigation Protocols in Immature Anterior Teeth. Eur Endod J. 2020;5(2):150-4. Epub 20200514. doi: 10.14744/eej.2020.20592. PubMed PMID: 32766527; PubMed Central PMCID: PMC7398988.
  • 6. Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves N, Hargreaves KM, et al. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips. J Endod. 2011;37(8):1109-15. doi: 10.1016/j.joen.2011.05.013. PubMed PMID: 21763903.
  • 7. Jäggi M, Magni E, Eggmann F, ElAyouti A, Connert T, Weiger R. Apical Pressure Generated Using Conventional Syringe Irrigation in Immature Teeth-An In Vitro Study. Materials (Basel). 2021;14(10). Epub 20210515. doi: 10.3390/ma14102580. PubMed PMID: 34063549; PubMed Central PMCID: PMC8156040.
  • 8. Siu C, Baumgartner JC. Comparison of the debridement efficacy of the EndoVac irrigation system and conventional needle root canal irrigation in vivo. J Endod. 2010;36(11):1782-5. Epub 20100916. doi: 10.1016/j.joen.2010.08.023. PubMed PMID: 20951287.
  • 9. Curtis TO, Sedgley CM. Comparison of a continuous ultrasonic irrigation device and conventional needle irrigation in the removal of root canal debris. J Endod. 2012;38(9):1261-4. Epub 20120630. doi: 10.1016/j.joen.2012.05.012. PubMed PMID: 22892747.
  • 10. Ramamoorthi S, Nivedhitha MS, Divyanand MJ. Comparative evaluation of postoperative pain after using endodontic needle and EndoActivator during root canal irrigation: A randomised controlled trial. Aust Endod J. 2015;41(2):78-87. Epub 20140904. doi: 10.1111/aej.12076. PubMed PMID: 25195661.
  • 11. İnce Yusufoglu S, Keskin NB, Saricam E, Bozkurt DA. Comparison of apical debris extrusion using EDDY, passive ultrasonic activation and photon-initiated photoacoustic streaming irrigation activation devices. Aust Endod J. 2020;46(3):400-4. Epub 20200903. doi: 10.1111/aej.12429. PubMed PMID: 32881182.
  • 12. Dos Reis S, Cruz VM, Hungaro Duarte MA, da Silveira Bueno CE, Vivan RR, Pelegrine RA, et al. Volumetric Analysis of Irrigant Extrusion in Immature Teeth after Different Final Agitation Techniques. J Endod. 2020;46(5):682-7. Epub 20200302. doi: 10.1016/j.joen.2020.01.014. PubMed PMID: 32139265.
  • 13. M SZ, R RN, V SP, Gowda Y, R MA. Reinforcing Effects of Calcium Silicate-based Cement and Dual Cure Composite Resin in Simulated Immature Teeth with an Open Apex: An in vitro Study. Int J Clin Pediatr Dent. 2017;10(4):351-7. Epub 20170227. doi: 10.5005/jp-journals-10005-1464. PubMed PMID: 29403228; PubMed Central PMCID: PMC5789138.
  • 14. Velmurugan N, Sooriaprakas C, Jain P. Apical Extrusion of Irrigants in Immature Permanent Teeth by Using EndoVac and Needle Irrigation: An In Vitro Study. J Dent (Tehran). 2014;11(4):433-9. Epub 20140731. PubMed PMID: 25584055; PubMed Central PMCID: PMC4283745.
  • 15. Chueh LH, Ho YC, Kuo TC, Lai WH, Chen YH, Chiang CP. Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod. 2009;35(2):160-4. Epub 20081212. doi: 10.1016/j.joen.2008.10.019. PubMed PMID: 19166764.
  • 16. Altundasar E, Nagas E, Uyanik O, Serper A. Debris and irrigant extrusion potential of 2 rotary systems and irrigation needles. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):e31-5. Epub 20110720. doi: 10.1016/j.tripleo.2011.03.044. PubMed PMID: 21778084.
  • 17. Garcia-Godoy F, Murray PE. Recommendations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol. 2012;28(1):33-41. Epub 20110727. doi: 10.1111/j.1600-9657.2011.01044.x. PubMed PMID: 21794081.
  • 18. Welbury R, Walton AG. Continued apexogenesis of immature permanent incisors following trauma. Br Dent J. 1999;187(12):643-4. doi: 10.1038/sj.bdj.4800356. PubMed PMID: 10654438.
  • 19. Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod. 2008;34(8):919-25; Discussion 1157. Epub 20080625. doi: 10.1016/j.joen.2008.05.001. PubMed PMID: 18634921. 20. Ok E, Altunsoy M, Tanriver M, Capar ID, Kalkan A, Gok T. Fracture resistance of simulated immature teeth after apexification with calcium silicate-based materials. Eur J Dent. 2016;10(2):188-92. doi: 10.4103/1305-7456.178301. PubMed PMID: 27095894; PubMed Central PMCID: PMC4813433.
  • 21. Aksel H, Askerbeyli S, Canbazoglu C, Serper A. Effect of needle insertion depth and apical diameter on irrigant extrusion in simulated immature permanent teeth. Braz Oral Res. 2014;28:1-6. doi: 10.1590/1807-3107bor-2014.vol28.0053. PubMed PMID: 25271966.
  • 22. Zhabuawala MS, Nadig RR, Pai VS, Gowda Y. Comparison of fracture resistance of simulated immature teeth with an open apex using Biodentine and composite resin: An in vitro study. J Indian Soc Pedod Prev Dent. 2016;34(4):377-82. doi: 10.4103/0970-4388.191424. PubMed PMID: 27681403.
  • 23. Topçuoglu HS, Akti A, Düzgün S, Ceyhanli KT, Topçuoglu G. Effectiveness of different irrigation procedures for removal of dentin debris from a simulated internal resorption cavity. Int J Artif Organs. 2015;38(3):165-9. Epub 20150326. doi: 10.5301/ijao.5000398. PubMed PMID: 25837879.
  • 24. Psimma Z, Boutsioukis C, Kastrinakis E, Vasiliadis L. Effect of needle insertion depth and root canal curvature on irrigant extrusion ex vivo. J Endod. 2013;39(4):521-4. Epub 20130130. doi: 10.1016/j.joen.2012.12.018. PubMed PMID: 23522549.
  • 25. Toyoğlu M, Altunbaş D. Influence of Different Kinematics on Apical Extrusion of Irrigant and Debris during Canal Preparation Using K3XF Instruments. J Endod. 2017;43(9):1565-8. Epub 20170720. doi: 10.1016/j.joen.2017.05.001. PubMed PMID: 28735794.
  • 26. Rodríguez-Figueroa C, McClanahan SB, Bowles WR. Spectrophotometric determination of irrigant extrusion using passive ultrasonic irrigation, EndoActivator, or syringe irrigation. J Endod. 2014;40(10):1622-6. Epub 20140429. doi: 10.1016/j.joen.2014.03.017. PubMed PMID: 25260734.
  • 27. Azim AA, Aksel H, Margaret Jefferson M, Huang GT. Comparison of sodium hypochlorite extrusion by five irrigation systems using an artificial root socket model and a quantitative chemical method. Clin Oral Investig. 2018;22(2):1055-61. Epub 20170726. doi: 10.1007/s00784-017-2187-y. PubMed PMID: 28748298.
  • 28. Akçay A, Gorduysus M, Rahman B, Gorduysus MO, Asaeli AP, Yuliati A, et al. Effects of six different irrigation systems on potential apical extrusion of irrigants. J Int Dent Med Res. 2019;12(1):1-5.
  • 29. Boutsioukis C, Psimma Z, van der Sluis LW. Factors affecting irrigant extrusion during root canal irrigation: a systematic review. Int Endod J. 2013;46(7):599-618. Epub 20130104. doi: 10.1111/iej.12038. PubMed PMID: 23289914.
  • 30. Gupta J, Nikhil V, Jha P. Corelation between machines assisted endodontic irrigant agitation and apical extrusion of debris and irrigant: a laboratory study. ScientificWorldJournal. 2014;2014:346184. Epub 20141016. doi: 10.1155/2014/346184. PubMed PMID: 25386593; PubMed Central PMCID: PMC4214052.
  • 31. Rungcharoenporn N, Pimkhaokham S. Comparison in amount of sodium hypochlorite extrusion during irrigation with needle-syringe and EndoActivator: in vitro study. CU Dent J. 2014;37:39-46.

Efficacy of Different Irrigation Activation Methods on the Amount of Extruded Irrigation Solution in Teeth with Simulated Immature Apex

Year 2025, Volume: 26 Issue: 3, 263 - 270, 22.09.2025
https://doi.org/10.69601/meandrosmdj.1614135

Abstract

Objective: The study aimed to quantitatively evaluate the effects of four final irrigation activation methods—standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), EndoActivator (EA), and EDDY—on apical irrigant extrusion in teeth with simulated immature apex.

Materials and Methods: Sixty single-rooted teeth with single canals were prepared up to the X3 instrument of the ProTaper Next system. To simulate open apices, Gates Glidden burs (#1–#6) were used, standardizing the apical diameter to 1.5 mm. The canals were irrigated with 2.5% NaOCl, 17% EDTA, and distilled water. Each tooth was mounted in the cap of an Eppendorf tube, allowing drainage through a 27G needle positioned at the root tip. The tubes were filled with NaOCl. Samples were randomly divided into four groups (n=15) based on the irrigation activation method: SNI, PUI, EA, and EDDY. In all groups, 6 ml of 2.5% NaOCl was activated over 3 minutes. The extruded irrigant was collected using an insulin syringe, and the volume was recorded in milliliters.

Results: Data normality was assessed with the Kolmogorov-Smirnov test. Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests (p<.05). The highest mean irrigant extrusion occurred in the SNI and PUI groups, while the EA group exhibited lower extrusion compared to others. However, no statistically significant difference was found among the methods regarding the mean volume of extruded irrigant (p>.05).

Conclusion: This study highlights that all tested irrigation activation methods perform similarly in controlling apical extrusion in teeth with immature apex.

References

  • 1. Kaya-Büyükbayram I, Özalp Ş, Aytugar E, Aydemir S. Regenerative endodontic treatment of an infected immature dens invaginatus with the aid of cone-beam computed tomography. Case Rep Dent. 2014;2014:403045. Epub 20141030. doi: 10.1155/2014/403045. PubMed PMID: 25530890; PubMed Central PMCID: PMC4229997.
  • 2. Cehreli ZC, Isbitiren B, Sara S, Erbas G. Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series. J Endod. 2011;37(9):1327-30. Epub 20110713. doi: 10.1016/j.joen.2011.05.033. PubMed PMID: 21846559.
  • 3. Cehreli ZC, Sara S, Aksoy B. Revascularization of immature permanent incisors after severe extrusive luxation injury. J Can Dent Assoc. 2012;78:c4. PubMed PMID: 22322021.
  • 4. Trope M. Treatment of the immature tooth with a non-vital pulp and apical periodontitis. Dent Clin North Am. 2010;54(2):313-24. doi: 10.1016/j.cden.2009.12.006. PubMed PMID: 20433980.
  • 5. Sharma R, Kumar V, Logani A, Chawla A, Sharma S, Koli B. Effect of Gravity on Periapical Extrusion of Irrigating Solution With Different Irrigation Protocols in Immature Anterior Teeth. Eur Endod J. 2020;5(2):150-4. Epub 20200514. doi: 10.14744/eej.2020.20592. PubMed PMID: 32766527; PubMed Central PMCID: PMC7398988.
  • 6. Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves N, Hargreaves KM, et al. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips. J Endod. 2011;37(8):1109-15. doi: 10.1016/j.joen.2011.05.013. PubMed PMID: 21763903.
  • 7. Jäggi M, Magni E, Eggmann F, ElAyouti A, Connert T, Weiger R. Apical Pressure Generated Using Conventional Syringe Irrigation in Immature Teeth-An In Vitro Study. Materials (Basel). 2021;14(10). Epub 20210515. doi: 10.3390/ma14102580. PubMed PMID: 34063549; PubMed Central PMCID: PMC8156040.
  • 8. Siu C, Baumgartner JC. Comparison of the debridement efficacy of the EndoVac irrigation system and conventional needle root canal irrigation in vivo. J Endod. 2010;36(11):1782-5. Epub 20100916. doi: 10.1016/j.joen.2010.08.023. PubMed PMID: 20951287.
  • 9. Curtis TO, Sedgley CM. Comparison of a continuous ultrasonic irrigation device and conventional needle irrigation in the removal of root canal debris. J Endod. 2012;38(9):1261-4. Epub 20120630. doi: 10.1016/j.joen.2012.05.012. PubMed PMID: 22892747.
  • 10. Ramamoorthi S, Nivedhitha MS, Divyanand MJ. Comparative evaluation of postoperative pain after using endodontic needle and EndoActivator during root canal irrigation: A randomised controlled trial. Aust Endod J. 2015;41(2):78-87. Epub 20140904. doi: 10.1111/aej.12076. PubMed PMID: 25195661.
  • 11. İnce Yusufoglu S, Keskin NB, Saricam E, Bozkurt DA. Comparison of apical debris extrusion using EDDY, passive ultrasonic activation and photon-initiated photoacoustic streaming irrigation activation devices. Aust Endod J. 2020;46(3):400-4. Epub 20200903. doi: 10.1111/aej.12429. PubMed PMID: 32881182.
  • 12. Dos Reis S, Cruz VM, Hungaro Duarte MA, da Silveira Bueno CE, Vivan RR, Pelegrine RA, et al. Volumetric Analysis of Irrigant Extrusion in Immature Teeth after Different Final Agitation Techniques. J Endod. 2020;46(5):682-7. Epub 20200302. doi: 10.1016/j.joen.2020.01.014. PubMed PMID: 32139265.
  • 13. M SZ, R RN, V SP, Gowda Y, R MA. Reinforcing Effects of Calcium Silicate-based Cement and Dual Cure Composite Resin in Simulated Immature Teeth with an Open Apex: An in vitro Study. Int J Clin Pediatr Dent. 2017;10(4):351-7. Epub 20170227. doi: 10.5005/jp-journals-10005-1464. PubMed PMID: 29403228; PubMed Central PMCID: PMC5789138.
  • 14. Velmurugan N, Sooriaprakas C, Jain P. Apical Extrusion of Irrigants in Immature Permanent Teeth by Using EndoVac and Needle Irrigation: An In Vitro Study. J Dent (Tehran). 2014;11(4):433-9. Epub 20140731. PubMed PMID: 25584055; PubMed Central PMCID: PMC4283745.
  • 15. Chueh LH, Ho YC, Kuo TC, Lai WH, Chen YH, Chiang CP. Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod. 2009;35(2):160-4. Epub 20081212. doi: 10.1016/j.joen.2008.10.019. PubMed PMID: 19166764.
  • 16. Altundasar E, Nagas E, Uyanik O, Serper A. Debris and irrigant extrusion potential of 2 rotary systems and irrigation needles. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):e31-5. Epub 20110720. doi: 10.1016/j.tripleo.2011.03.044. PubMed PMID: 21778084.
  • 17. Garcia-Godoy F, Murray PE. Recommendations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol. 2012;28(1):33-41. Epub 20110727. doi: 10.1111/j.1600-9657.2011.01044.x. PubMed PMID: 21794081.
  • 18. Welbury R, Walton AG. Continued apexogenesis of immature permanent incisors following trauma. Br Dent J. 1999;187(12):643-4. doi: 10.1038/sj.bdj.4800356. PubMed PMID: 10654438.
  • 19. Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod. 2008;34(8):919-25; Discussion 1157. Epub 20080625. doi: 10.1016/j.joen.2008.05.001. PubMed PMID: 18634921. 20. Ok E, Altunsoy M, Tanriver M, Capar ID, Kalkan A, Gok T. Fracture resistance of simulated immature teeth after apexification with calcium silicate-based materials. Eur J Dent. 2016;10(2):188-92. doi: 10.4103/1305-7456.178301. PubMed PMID: 27095894; PubMed Central PMCID: PMC4813433.
  • 21. Aksel H, Askerbeyli S, Canbazoglu C, Serper A. Effect of needle insertion depth and apical diameter on irrigant extrusion in simulated immature permanent teeth. Braz Oral Res. 2014;28:1-6. doi: 10.1590/1807-3107bor-2014.vol28.0053. PubMed PMID: 25271966.
  • 22. Zhabuawala MS, Nadig RR, Pai VS, Gowda Y. Comparison of fracture resistance of simulated immature teeth with an open apex using Biodentine and composite resin: An in vitro study. J Indian Soc Pedod Prev Dent. 2016;34(4):377-82. doi: 10.4103/0970-4388.191424. PubMed PMID: 27681403.
  • 23. Topçuoglu HS, Akti A, Düzgün S, Ceyhanli KT, Topçuoglu G. Effectiveness of different irrigation procedures for removal of dentin debris from a simulated internal resorption cavity. Int J Artif Organs. 2015;38(3):165-9. Epub 20150326. doi: 10.5301/ijao.5000398. PubMed PMID: 25837879.
  • 24. Psimma Z, Boutsioukis C, Kastrinakis E, Vasiliadis L. Effect of needle insertion depth and root canal curvature on irrigant extrusion ex vivo. J Endod. 2013;39(4):521-4. Epub 20130130. doi: 10.1016/j.joen.2012.12.018. PubMed PMID: 23522549.
  • 25. Toyoğlu M, Altunbaş D. Influence of Different Kinematics on Apical Extrusion of Irrigant and Debris during Canal Preparation Using K3XF Instruments. J Endod. 2017;43(9):1565-8. Epub 20170720. doi: 10.1016/j.joen.2017.05.001. PubMed PMID: 28735794.
  • 26. Rodríguez-Figueroa C, McClanahan SB, Bowles WR. Spectrophotometric determination of irrigant extrusion using passive ultrasonic irrigation, EndoActivator, or syringe irrigation. J Endod. 2014;40(10):1622-6. Epub 20140429. doi: 10.1016/j.joen.2014.03.017. PubMed PMID: 25260734.
  • 27. Azim AA, Aksel H, Margaret Jefferson M, Huang GT. Comparison of sodium hypochlorite extrusion by five irrigation systems using an artificial root socket model and a quantitative chemical method. Clin Oral Investig. 2018;22(2):1055-61. Epub 20170726. doi: 10.1007/s00784-017-2187-y. PubMed PMID: 28748298.
  • 28. Akçay A, Gorduysus M, Rahman B, Gorduysus MO, Asaeli AP, Yuliati A, et al. Effects of six different irrigation systems on potential apical extrusion of irrigants. J Int Dent Med Res. 2019;12(1):1-5.
  • 29. Boutsioukis C, Psimma Z, van der Sluis LW. Factors affecting irrigant extrusion during root canal irrigation: a systematic review. Int Endod J. 2013;46(7):599-618. Epub 20130104. doi: 10.1111/iej.12038. PubMed PMID: 23289914.
  • 30. Gupta J, Nikhil V, Jha P. Corelation between machines assisted endodontic irrigant agitation and apical extrusion of debris and irrigant: a laboratory study. ScientificWorldJournal. 2014;2014:346184. Epub 20141016. doi: 10.1155/2014/346184. PubMed PMID: 25386593; PubMed Central PMCID: PMC4214052.
  • 31. Rungcharoenporn N, Pimkhaokham S. Comparison in amount of sodium hypochlorite extrusion during irrigation with needle-syringe and EndoActivator: in vitro study. CU Dent J. 2014;37:39-46.
There are 30 citations in total.

Details

Primary Language English
Subjects Dentistry (Other)
Journal Section Research Article
Authors

Merve Ölmez 0000-0002-4095-5042

Zeliha Uğur Aydın 0000-0002-1773-9114

Hulde Korucu 0000-0002-7389-9470

Publication Date September 22, 2025
Submission Date January 17, 2025
Acceptance Date June 5, 2025
Published in Issue Year 2025 Volume: 26 Issue: 3

Cite

EndNote Ölmez M, Uğur Aydın Z, Korucu H (September 1, 2025) Efficacy of Different Irrigation Activation Methods on the Amount of Extruded Irrigation Solution in Teeth with Simulated Immature Apex. Meandros Medical And Dental Journal 26 3 263–270.