Research Article
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Investigation of Different Pediatric Multivitamins and Mineral Supplements on the Color Stability of Resin-based Restorative Materials

Year 2025, Volume: 26 Issue: 3, 248 - 256, 22.09.2025
https://doi.org/10.69601/meandrosmdj.1695385

Abstract

Objective:This study aimed to investigate the effect of different pediatric multivitamins and mineral supplements on the discoloration and surface roughness of various resin based restorative materials.
Materials and Methods:40 samples of nanohybrid(Charisma Topaz,Kulzer,Germany) and 40 samples of microhybrid (Charisma Classic,Kulzer,Germany) composite resin were prepared with standard size molds. Baseline color measurement(T1) was made from each sample based on CIE L*a*b* system.Each sample was immersed in 5 different pediatric multivitamin and mineral supplements(iron, Sambucus nigra, resveratrol, propolis and distilled water) for 7 days.Color differences in each specimen were assessed using Δ𝐸∗ values measured with a spectrophotometer on day 1(T2) and day 7(T3).One sample from each group was randomly selected and stereo microscope images were obtained and surface roughness evaluated.Normal distribution was checked by Shapiro Wilk test and then repeated measures ANOVA was employed for statistical analysis.Statistical significance was defined at 0.05.
Results:In nanohybrid and microhybrid composites, statistically significant color change was observed between ΔE2 with ΔE1 and ΔE3 for resveratrol and propolis solution (p<0.001 and p<0.001).In nanohybrid composites, the highest color change difference between baseline and Day 7 (ΔE2) was observed in the resveratrol group (28.26±4,93),while in microhybrid composites,it belonged to the propolis group (26.82±5,44).Propolis solution discolored the microhybrid composite statistically significantly more than nanohybrid composite for Δ𝐸2.There is no statistically significant difference between the color change of microhybrid composites and nanohybrid composites for other solutions.
Conclusion:The color and surface of resin based restorative materials are esthetically unacceptably changed by long-term usage of multivitamins in particular containing resveratrol and propolis.

Ethical Statement

This study did not involve any biological materials; instead, it conducted experiments solely on dental materials. Therefore, there was no need for ethics committee approval.

References

  • 1. Bhandari N, Bahl R, Taneja S. Effect of micronutrient supplementation on linear growth of children. Br J Nutr. 2001;85(S2):S131.
  • 2. Rerksuppaphol S, Rerksuppaphol L. Effect of zinc plus multivitamin supplementation on growth in school children. Pediatr Int. 2016;58(11):1193–9.
  • 3. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients. 2019;11(11).
  • 4. Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 SUPPL.):560–71.
  • 5. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: A systematic review and meta-analysis. Nutr J. 2010;9(1):1–16.
  • 6. Harnett J, Oakes K, Carè J, Leach M, Brown D, Cramer H, et al. The effects of Sambucus nigra berry on acute respiratory viral infections: A rapid review of clinical studies. Adv Integr Med. 2020;7(4):240–6.
  • 7. Inchingolo AD, Inchingolo AM, Malcangi G, Avantario P, Azzollini D, Buongiorno S, et al. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review. Vol. 14, Nutrients. 2022.
  • 8. Martini L, Pecoraro L, Salvottini C, Piacentini G, Atkinson R, Pietrobelli A. Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020;9:1–8.
  • 9. Mentes A. pH changes in dental plaque after using sugar-free pediatric medicine. J Clin Pediatr Dent. 2001;25(4).
  • 10. Costa CC, Almeida ICS, Costa Filho LC. Erosive effect of an antihistamine-containing syrup on primary enamel and its reduction by fluoride dentifrice. Int J Paediatr Dent. 2006;16(3):174–80.
  • 11. Maguire A, Baqir W, Nunn JH. Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children. Int J Paediatr Dent. 2007;17(4):231–8.
  • 12. Tüzüner T, Turgut S, Baygin O, Yilmaz N, Tuna EB, Ozen B. Effects of Different Pediatric Drugs on the Color Stability of Various Restorative Materials Applicable in Pediatric Dentistry. Biomed Res Int. 2017;2017.
  • 13. Faghihi T, Heidarzadeh Z, Jafari K, Farhoudi I, Hekmatfar S. An experimental study on the effect of four pediatric drug types on color stability in different tooth-colored restorative materials. Dent Res J (Isfahan). 2021;18(1):1–6.
  • 14. Almutairi M, Moussa I, Alsaeri N, Alqahtani A, Alsulaiman S, Alhajri M. The Effects of Different Pediatric Drugs and Brushing on the Color Stability of Esthetic Restorative Materials Used in Pediatric Dentistry: An In Vitro Study. Children. 2022;9(7):5–8.
  • 15. Çapan BŞ, Birant S. Effect of pediatric drugs on the color stability of dental restorative materials currently used in pediatric dentistry. J Aust Ceram Soc [Internet]. 2024;(0123456789). Available from: https://doi.org/10.1007/s41779-024-00991-2
  • 16. Jamal DY, Farsi NM, El-Housseiny AA, Felemban OM. Effects of pediatric liquid medications on surface properties of dental restorations. Med Sci. 2022;26(120):1.
  • 17. Valera B, Bhatt R, Patel M, Patel C, Makwani D, Goyal S. Effect of different pediatric medications on various tooth colored restorative materials used in pediatric dentistry. Int J Health Sci (Qassim). 2022;6(March):508–21.
  • 18. Doğu Kaya B, Yılmaz Atalı P, Özmen S, Öztürk S, Tarçın B. Effect of an Effervescent Multivitamin on Color and Surface Roughness of Micro-Hybrid Dental Resin Composites. Materials (Basel). 2024;17(5).
  • 19. Nasim I, Neelakantan P, Sujeer R, Subbarao C V. Color stability of microfilled, microhybrid and nanocomposite resins - An in vitro study. J Dent [Internet]. 2010;38(SUPPL. 2):e137–42. Available from: http://dx.doi.org/10.1016/j.jdent.2010.05.020
  • 20. Lehmann KM, Devigus A, Igiel C, Weyhrauch M, Schmidtmann I, Wentaschek S, et al. Are dental color measuring devices CIE compliant? Eur J Esthet Dent. 2012;7(3):324–33.
  • 21. Paravina RD, Pérez MM, Ghinea R. Acceptability and perceptibility thresholds in dentistry: A comprehensive review of clinical and research applications. J Esthet Restor Dent. 2019;31(2):103–12.
  • 22. Zhou ZR, Zheng J. Tribology of dental materials: A review. J Phys D Appl Phys. 2008;41(11).
  • 23. Hong G, Yang J, Jin X, Wu T, Dai S, Xie H, et al. Mechanical properties of nanohybrid resin composites containing various mass fractions of modified zirconia particles. Int J Nanomedicine. 2020;15:9891–907.
  • 24. Erturk-Avunduk AST, Aksu S, Delikan E. The Effects of Mouthwashes on the Color Stability of Resin-Based Restorative Materials. Odovtos - Int J Dent Sci. 2021;23(1):91–102.
  • 25. Çelik ZC, Elbek Çubukçu Ç, Batmaz SG. Exploring the discoloration potential of Propolis extract and Morus nigra syrup on restorative dental composites: an in vitro study. J Heal Sci Med. 2023;6(2):289–93.

Farklı Pediatrik Multivitamin ve Mineral Takviyelerinin Rezin Esaslı Restoratif Materyallerin Renk Stabilitesi Üzerine Etkisinin Araştırılması

Year 2025, Volume: 26 Issue: 3, 248 - 256, 22.09.2025
https://doi.org/10.69601/meandrosmdj.1695385

Abstract

Amaç:Bu çalışmanın amacı farklı pediatrik multivitamin ve mineral takviyelerinin çeşitli rezin esaslı restoratif materyallerin renklenme ve yüzey pürüzlülüğü üzerine etkisini araştırmaktır.
Gereç ve Yöntem:40 adet nanohibrit (Charisma Topaz,Kulzer,Almanya) ve 40 adet mikrohibrit (Charisma Classic,Kulzer,Almanya) kompozit rezin örnek standart boyutlardaki kalıplarla hazırlandı.Her örnekten CIE L*a*b* sistemine göre başlangıç renk ölçümü(T1) yapıldı. 5 farklı pediatrik multivitamin ve mineral takviyesine (demir,Sambucus nigra,resveratrol,propolis ve distile su) 7 gün boyunca daldırılan her örnekteki renk farklılıkları, 1. gün (T2) ve 7. gün (T3) spektrofotometre ile ölçülen Δ𝐸∗ ile değerlendirildi. Her gruptan bir örnek rastgele seçilerek stere mikroskop görüntüleri elde edilmiş ve yüzey pürüzlülüğü incelendi. Normal dağılım Shapiro-Wilk testi ile kontrol edilmiş ve ardından istatistiksel analiz için tekrarlanan ölçümler ANOVA kullanılmıştır. 0,05 istatistiksel anlamlılık olarak tanımlanmıştır.
Bulgular:Nanohibrit ve mikrohibrit kompozitlerde, resveratrol ve propolis solüsyonu için ΔE2 ile ΔE1 ve ΔE3 arasında istatistiksel olarak anlamlı renk değişimi gözlenmiştir(p<0.001 ve p<0.001).Nanohibrit kompozitlerde, başlangıç ve 7.gün(ΔE2) arasındaki en yüksek renk değişimi farkı resveratrol grubunda(28.26±4,93), mikrohibrit kompozitlerde ise propolis grubuna(26,82±5,44) aittir.Δ𝐸2 için propolis solüsyonu mikrohibrit kompozitin rengini nanohibrit kompozitten istatistiksel olarak anlamlı şekilde daha fazla değiştirmiştir.Diğer solüsyonlar için mikrohibrit ve nanohibrit kompozitlerin renk değişimi arasında istatistiksel olarak anlamlı bir fark yoktur.
Sonuç:Rezin esaslı restoratif materyallerin rengi ve yüzeyi, özellikle resveratrol ve propolis içeren multivitaminlerin uzun süreli kullanımı ile estetik olarak kabul edilemez şekilde değişmektedir.

References

  • 1. Bhandari N, Bahl R, Taneja S. Effect of micronutrient supplementation on linear growth of children. Br J Nutr. 2001;85(S2):S131.
  • 2. Rerksuppaphol S, Rerksuppaphol L. Effect of zinc plus multivitamin supplementation on growth in school children. Pediatr Int. 2016;58(11):1193–9.
  • 3. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients. 2019;11(11).
  • 4. Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 SUPPL.):560–71.
  • 5. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: A systematic review and meta-analysis. Nutr J. 2010;9(1):1–16.
  • 6. Harnett J, Oakes K, Carè J, Leach M, Brown D, Cramer H, et al. The effects of Sambucus nigra berry on acute respiratory viral infections: A rapid review of clinical studies. Adv Integr Med. 2020;7(4):240–6.
  • 7. Inchingolo AD, Inchingolo AM, Malcangi G, Avantario P, Azzollini D, Buongiorno S, et al. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review. Vol. 14, Nutrients. 2022.
  • 8. Martini L, Pecoraro L, Salvottini C, Piacentini G, Atkinson R, Pietrobelli A. Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020;9:1–8.
  • 9. Mentes A. pH changes in dental plaque after using sugar-free pediatric medicine. J Clin Pediatr Dent. 2001;25(4).
  • 10. Costa CC, Almeida ICS, Costa Filho LC. Erosive effect of an antihistamine-containing syrup on primary enamel and its reduction by fluoride dentifrice. Int J Paediatr Dent. 2006;16(3):174–80.
  • 11. Maguire A, Baqir W, Nunn JH. Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children. Int J Paediatr Dent. 2007;17(4):231–8.
  • 12. Tüzüner T, Turgut S, Baygin O, Yilmaz N, Tuna EB, Ozen B. Effects of Different Pediatric Drugs on the Color Stability of Various Restorative Materials Applicable in Pediatric Dentistry. Biomed Res Int. 2017;2017.
  • 13. Faghihi T, Heidarzadeh Z, Jafari K, Farhoudi I, Hekmatfar S. An experimental study on the effect of four pediatric drug types on color stability in different tooth-colored restorative materials. Dent Res J (Isfahan). 2021;18(1):1–6.
  • 14. Almutairi M, Moussa I, Alsaeri N, Alqahtani A, Alsulaiman S, Alhajri M. The Effects of Different Pediatric Drugs and Brushing on the Color Stability of Esthetic Restorative Materials Used in Pediatric Dentistry: An In Vitro Study. Children. 2022;9(7):5–8.
  • 15. Çapan BŞ, Birant S. Effect of pediatric drugs on the color stability of dental restorative materials currently used in pediatric dentistry. J Aust Ceram Soc [Internet]. 2024;(0123456789). Available from: https://doi.org/10.1007/s41779-024-00991-2
  • 16. Jamal DY, Farsi NM, El-Housseiny AA, Felemban OM. Effects of pediatric liquid medications on surface properties of dental restorations. Med Sci. 2022;26(120):1.
  • 17. Valera B, Bhatt R, Patel M, Patel C, Makwani D, Goyal S. Effect of different pediatric medications on various tooth colored restorative materials used in pediatric dentistry. Int J Health Sci (Qassim). 2022;6(March):508–21.
  • 18. Doğu Kaya B, Yılmaz Atalı P, Özmen S, Öztürk S, Tarçın B. Effect of an Effervescent Multivitamin on Color and Surface Roughness of Micro-Hybrid Dental Resin Composites. Materials (Basel). 2024;17(5).
  • 19. Nasim I, Neelakantan P, Sujeer R, Subbarao C V. Color stability of microfilled, microhybrid and nanocomposite resins - An in vitro study. J Dent [Internet]. 2010;38(SUPPL. 2):e137–42. Available from: http://dx.doi.org/10.1016/j.jdent.2010.05.020
  • 20. Lehmann KM, Devigus A, Igiel C, Weyhrauch M, Schmidtmann I, Wentaschek S, et al. Are dental color measuring devices CIE compliant? Eur J Esthet Dent. 2012;7(3):324–33.
  • 21. Paravina RD, Pérez MM, Ghinea R. Acceptability and perceptibility thresholds in dentistry: A comprehensive review of clinical and research applications. J Esthet Restor Dent. 2019;31(2):103–12.
  • 22. Zhou ZR, Zheng J. Tribology of dental materials: A review. J Phys D Appl Phys. 2008;41(11).
  • 23. Hong G, Yang J, Jin X, Wu T, Dai S, Xie H, et al. Mechanical properties of nanohybrid resin composites containing various mass fractions of modified zirconia particles. Int J Nanomedicine. 2020;15:9891–907.
  • 24. Erturk-Avunduk AST, Aksu S, Delikan E. The Effects of Mouthwashes on the Color Stability of Resin-Based Restorative Materials. Odovtos - Int J Dent Sci. 2021;23(1):91–102.
  • 25. Çelik ZC, Elbek Çubukçu Ç, Batmaz SG. Exploring the discoloration potential of Propolis extract and Morus nigra syrup on restorative dental composites: an in vitro study. J Heal Sci Med. 2023;6(2):289–93.
There are 25 citations in total.

Details

Primary Language English
Subjects Dentistry (Other)
Journal Section Research Article
Authors

Aslı Aşık 0000-0003-4865-3249

Sibel Acar 0000-0002-9303-8360

Özant Önçağ 0000-0001-7913-6928

Publication Date September 22, 2025
Submission Date May 8, 2025
Acceptance Date August 5, 2025
Published in Issue Year 2025 Volume: 26 Issue: 3

Cite

EndNote Aşık A, Acar S, Önçağ Ö (September 1, 2025) Investigation of Different Pediatric Multivitamins and Mineral Supplements on the Color Stability of Resin-based Restorative Materials. Meandros Medical And Dental Journal 26 3 248–256.