Comparison Of The Relationship Between Inflammatory Markers And Saphenous Vein Graft Disease In Patients With Stable Angina Pectoris.

Year 2023, , 213 - 218, 31.12.2023

Çağrı Zorlu , Sefa Erdi Ömür , Samet Yılmaz

https://doi.org/10.30565/medalanya.1291772

Abstract

Aim: Coronary artery bypass graft surgery is one of the most commonly used strategies to revascularization of occlusive coronary atherosclerotic lesions. Atherosclerosis is known to be a chronic inflammatory process. Many inflammatory cells and mechanisms are active in this process. Markers such as mean platelet volume-to-lymphocyte ratio (MPVLR) and C-reactive protein-to-albumin (CAR) which may be associated with the severity of inflammation. In this study, it was aimed to determine the relationship between these parameters and saphenous vein graft (SVG) diseases.

Methods: In this retrospective study, 314 patients SVG disease with stable angina pectoris were included. Patients were divided into two groups according to the severity of SVG disease. We compared 159 patients who had severe stenosis in SVG and 156 patients who did not,in terms of CAR, NLR, PLR, MPVLR.

Results: Patients who ≥50% stenosis in SVG had significantly higher CAR, MPVLR, NLR, and PLR (respectively 9.1 (4.2-16.8) p<0.001, 4.5)0.68) p<0.001, 2.4 (0.69) p=0.002, 153 )6) p=0.048). In line with these data, CAR and MPVLR values were also higher in the group with ≥50% stenosis in SVG, which was highly statistically significant (respectively 3.2 (0.9-4.4) vs 9.1 (4.2-16.8); p<0.001 and 3.64)0.43) vs 4.53)0.68); p<0.001).

Conclusion: C-reactive protein-to-albumin and MPVLR can be a useful and easily accessible markers to predict severity SVG stenosis.

Keywords

C-reactive protein-to-albumin, mean platelet volume-to-lymphocytes ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, saphenous vein graft diseases.

Stabil Anjina Pektorisli Hastalarda İnflamatuvar Belirteçler ile Safen Damar Grefti Hastalığı Arasındaki İlişkinin Karşılaştırılması.

Abstract

Amaç: Koroner arter baypas greft cerrahisi, tıkayıcı koroner aterosklerotik lezyonların revaskülarizasyonu için en sık kullanılan stratejilerden biridir. Aterosklerozun kronik bir inflamatuar süreç olduğu bilinmektedir. Bu süreçte birçok enflamatuar hücre ve mekanizma aktiftir. Enflamasyonun ciddiyeti ile ilişkili olabilecek biyobelirteçler; ortalama trombosit hacmi-lenfosit oranı (MPVLR) ve C-reaktif protein-albümin (CAR), nötrofil-lenfosit oranı (NLR) ve platelet-lenfosit oranı (PLR)’dir. Bu çalışmada bu parametreler ile safen ven grefti (SVG) hastalıkları arasındaki ilişkinin belirlenmesi amaçlanmıştır.

Yöntemler: Bu retrospektif çalışmaya stabil anjina pektorisli SVG hastalığı olan 314 hasta dahil edildi. Hastalar SVG hastalığının şiddetine göre iki gruba ayrıldı. SVG'de ciddi darlık olan 159 hasta ile darlık olmayan 156 hastayı CAR, NLR, PLR, MPVLR açısından karşılaştırdık.

Bulgular: SVG'de ≥%50 darlığı olan hastalarda CAR, MPVLR, NLR ve PLR anlamlı olarak daha yüksekti (sırasıyla 9.1 (4.2-16.8) p<0.001, 4.5(0.68) p<0.001, 2.4 (0.69) p=0.002, 153 (6) p=0.048). Bu veriler doğrultusunda SVG'de ≥%50 darlık olan grupta CAR ve MPVLR değerleri de istatistiksel olarak anlamlıydı (sırasıyla 3,2 (0,9-4,4) ve 9,1 (4,2-16,8); p<0,001 ve 3,64 (0,43) - 4,53(0,68); p<0.001).

Sonuç: C-reaktif protein-albümin ve MPVLR, SVG stenozunun ciddiyetini tahmin etmek için yararlı ve kolay erişilebilir bir belirteç olabilir.

Keywords

C-reactive protein-albumin oranı, ortalama platelet hacmi- lenfosit oranı, nötrofil-lenfosit oranı, platelet-lenfosit oranı, safen ven greft hastalığı

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