May Serum Creatine Kınase (CK) Level Be a Malnutrition Parameter In Patients Wıth End-Stage Kidney Failure?

Year 2020, , 137 - 143, 12.07.2020

Ahmet Peker , Harun Akar , Mehmet Tanrısev

https://doi.org/10.30565/medalanya.679570

Abstract

Aim: The aim of this study was to investigate the relationship between serum CK levels and malnutrition parameters in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD) for end stage renal disease (ESRD).

Methods: In this prospective study, 60 patients receiving HD and 30 patients receiving PD for ESRD were evaluated. The relationship between serum CK levels and Mini Nutritional Assessment (MNA) Test scores, albumin, C-Reactive Protein (CRP), arterial blood gas parameters, KT / V ratio, total body water, muscle mass, body mass index (BMI) and lean body mass (determined by Bioelectrical Impedance Analysis (BIA) were examined.

Results: No correlation was found between CK levels and age, dialysis duration and Ca values in HD and PD patients (p> 0.05). A positive correlation was found between CK levels and MNA scores and triceps skinfold thickness, lean body mass, body muscle mass and BMI values of PD and HD patients, and a significant negative correlation between total body water values (p <0.001).

Conclusions: It was determined that serum CK level was compatible with other parameters used in the determination and follow-up of nutritional disorder and sarcopenia in ESRD patients. 

Keywords

End-Stage Renal Disease, Bioelectrical Impedance, Creatine Kinase, , Sarcopenia, , Malnutrition

Son Dönem Böbrek Yetmezliği Hastalarinda Serum Kreatin Kinaz (Ck) Düzeyi Malnutrisyon Parametresi Olabilir Mi?

Abstract

Amaç: Bu çalışmanın amacı; Son Dönem Böbrek Yetmezliği (SDBY) nedeniyle hemodiyaliz (HD) ve periton diyalizi (PD) tedavisi alan hastalarda serum CK düzeyleri ile malnutrisyon parametreleri arasındaki ilişkiyi incelemektir.

Gereç ve Yöntem: Prospektif olarak yürütülen bu çalışmada, Türkiye’ nin Ege bölgesinde hizmet veren bir hastanede SDBY nedeniyle HD tedavisi alan 60 hasta ve PD tedavisi alan 30 hasta değerlendirildi. Hastaların serum CK düzeyi ile Mini Nutrisyonel Değerlendirme Testi (MND)’ nden aldıkları puanlar, albumin ve C-Reaktif Protein (CRP) gibi biokimyasal parametreler, arteriyel kan gazı değerleri, KT/V oranı, Biyoelektriksel İmpedans Analiz (BİA) yöntemiyle bakılan total vücut suyu, kas kütlesi, vücut kitle indeksi (VKİ) yağsız vücut kütlesi ve VYO (vücut yağ oranı) gibi değişkenler arasındaki ilişki incelendi.

Bulgular: HD ve PD hastalarında CK düzeyleri ile yaş, diyaliz süresi ve Ca değerleri arasında ilişki saptanmadı (p>0,05). HD ve PD hastalarının CK düzeyleri ve MND puanları ile BİA parametrelerinden yağsız vücut kütlesi, vücut kas kütlesi ve VKİ değerleri arasında pozitif yönde, TVS değerleri arasında negatif ilişki saptandı (p<0,001).

Sonuç: SDBY hastalarında serum CK düzeyinin, beslenme bozukluğu ve sarkopeninin belirlenmesi ve takibinde kullanılan diğer parametreler ile uyumlu olduğu görülmektedir. 

Keywords

Son Dönem Böbrek Hastalığı, Biyoelektriksel Empedans, Kreatin Kinaz, Sarkopeni, Malnütrisyon

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