Evaluation of inflammation in obesity and chronic kidney disease with hemogram parameters

Year 2021, , 276 - 281, 31.12.2021

İlter Bozacı , Erhan Tatar

https://doi.org/10.30565/medalanya.943299

Abstract

Aim: Chronic inflammation is involved in the pathogenesis of both obesity and chronic kidney disease (CKD). We aimed to evaluate the parameters derived from complete blood count (CBC) as inflammatory markers in obese patients and obese CKD patients.

Methods: Individuals enrolled in the study were divided into three groups. Group-1 was composed of obese patients; group-2 was composed of obese CKD patients and group-3 was composed of healthy individuals as the control group. This study was conducted at a training and research hospital over 6 months period.

Results: Forty-one patients were in group-1; 41 patients were in group-2 and 22 individuals were in group-3. White blood cell count (WBC) was significantly higher in group-1 and group-2 compared with group-3 (7,5±1,4 x10³/µL vs 8,4±2,4 x10³/µL vs 6,5±1,3 x10³/µL, respectively, p<0.001) and neutrophile to lymphocyte ratio (NLR) was significantly higher in group-1 and group-2 compared with group-3 (1,9±0,7 vs 2,5±1,5 vs 1,7±0,4, respectively, p<0.001). NLR and WBC was found positively correlated with systolic blood pressure, urea, creatinine, uric acid, whereas negatively correlated with estimated glomerular filtration rate.

Conclusion: It is important to determine significant results in CBC derived markers that are widely used in routine clinical practice as inflammatory markers.

Keywords

Inflammation, Renal Insufficiency, Blood cell count.

Obezite ve Kronik Böbrek Hastalığındaki İnflamasyonun Hemogram Parametreleri ile Değerlendirilmesi

Abstract

Amaç: Kronik inflamasyon hem obezitenin hem de kronik böbrek hastalığının patogenezi ile ilişkilidir. Çalışmamızda obez hastalarda ve obez kronik böbrek hastalarında inflamasyon belirteci olarak tam kan sayımı parametrelerinin değerlendirilmesini amaçladık.

Yöntemler: Çalışmada yer alan bireyler 3 ayrı gruba bölündü. Grup-1 obez hastalardan, grup-2 obez kronik böbrek hastalarından, grup-3 kontrol grubu olarak sağlıklı bireylerden oluşmakta idi. Çalışmamız, 6 aylık bir sürede bir eğitim ve araştırma hastanesinde gerçekleştirildi.

Bulgular: Kırkbir hasta grup-1’de; 41 hasta grup-2’de ve 22 sağlıklı birey grup-3’de yer aldı. Beyaz küre sayıları grup-3’e kıyasla grup-1 ve grup-2’de anlamlı düzeyde yüksek saptandı (7,5±1,4 x10³/µL vs 8,4±2,4 x10³/µL vs 6,5±1,3 x10³/µL, sırasıyla, p<0.001) ve nötrofil lenfosit oranı grup-3’e kıyasla grup-1 ve grup-2’de anlamlı düzeyde yüksek saptandı (1,9±0,7 vs 2,5±1,5 vs 1,7±0,4, sırasıyla, p<0.001). Nötrofil lenfosit oranı ve beyaz küre sayısının, sistolik kan basıncı, ürik asit, üre ve kreatinin arasında pozitif; glomerüler filtrasyon hızı ile negatif korelasyon saptandı.

Sonuç: Rutin klinik pratikte sıkça kullanılan hemogramdan elde edilen parametrelerin inflamasyon belirteçleri olarak anlamlı sonuçlanması önemlidir.

Keywords

Enflamasyon, Böbrek Yetmezliği, Kan Hücre Sayımı

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