Evaluation of Ocular Surface Disease in Glaucoma Patients Using Topical Antiglaucomatous Agents

Year 2017, Volume: 1 Issue: 3, 116 - 121, 15.12.2017

Tevfik Oğurel , Reyhan Oğurel Murat Atabey Özer Zafer Onaran

https://doi.org/10.30565/medalanya.342369

Cited By: 1

Abstract

Aim: Evaluation of ocular surface disease (OSD) in glaucoma patients using
topical antiglaucomatous agents

Patients
and Method: 159 eyes of 83 patients at the age 18 years or over,
who had any types of different glaucoma and had been using antiglaucomatous
agents for at least 6 months were included in the study. The Ocular Surface
Disease Index (OSDI) questionnaire was filled by asking patients individually.
Afterwards, in order to examine ocular surface clinically, patients underwent
the Schirmer test(under anesthesia) evaluation, tear break-up time(TBUT) and
corneal staining.

Results: A total of 159 eyes from 51 male and 32 female patients were included
in the study. The average age of men was 64,51 ± 9,07 and the average age of
women was 54,32 ± 11,44. Mean duration of medication use of the patients was
6.35 ± 5.63 years. 36.5% of the patients had single medication, 32.1% had two
medications, 13.8% had three medications and 17.6% had four medications. Of the
patients whose dry eye symptoms were assessed using the OSDI questionnaire,
3.8% were normal, 15.7% were mild, 22.6% were moderate and 57.9% were severe
dry eye. The mean OSDI score of all patients was 46.80 ± 19.44. The Schirmer
test was found at less than 5 mm in 34.1% of eyes. In terms of TBUT, 52.3% of
the eyes were evaluated as mild, 29.5% as moderate, 8.5% as severe. When
evaluated for corneal staining, normal staining was observed in 13.2%, slight
staining in 39.6%, moderate staining in 23.3% and severe staining in 23.9%.

Conclusion: In diagnosing OCD, it would also be beneficial to use a test that
includes not only the OSDI questionnaire but also tests showing the quality and
stability of the tears.

Keywords

Glaucoma, Antiglaucomatous agents, Ocular Surface Disease

Antiglokomatöz İlaç Kullanan Glokom Hastalarında Oküler Yüzey Hastalığının Değerlendirilmesi

Abstract

Amaç: Topikal antiglokomatöz
ilaç kullanan glokom hastalarında oküler yüzey hastalığını (OYH) değerlendirmek

Hastalar
ve Yöntem: Çalışmaya herhangi bir değişik tipte
glokomu olan ve en az 6 aydır glokom ilacı kullanan 18 yaş üstü 83 hastanın 159
gözü çalışmaya dâhil edildi. Oküler yüzey hastalık endeks(OSDI) anketi
hastalara tek tek sorularak dolduruldu. Sonrasında hastalarda oküler yüzeyi
klinik olarak değerlendirmek için schirmer testi (anestezili), gözyaşı kırılma
zamanı(GKZ) ve korneal boyanmaya bakıldı.

Bulgular: Çalışmaya
51 erkek 32 kadın hastanın 159 gözü dâhil edildi.  Erkeklerin yaş ortalaması 64,51±9,07
bayanların yaş ortalaması 54,32±11,44 idi. Hastaların ortalama ilaç kullanım
süreleri 6,35±5,63 yıldı. Hastaların %36,5’i tek ilaç ,%32,1’i iki ilaç,
%13,8’i üç ilaç ve %17,6’sı dört ilaç kullanmaktaydı. OSDI anketi kullanılarak
kuru göz semptomları değerlendirilen hastaların %3,8’i normal, % 15,7’si hafif,
%22,6’sı orta ve %57,9 şiddetli kuru göz hastası olarak değerlendirildi. Tüm
hastaların ortalama OSDI skoru 46,80±19,44’tü. Schirmer testi gözlerin
%34,1’inde 5 mm’nin altında saptandı. GKZ gözlerin % 52,3’de hafif,%29,5’de
orta, %8,5,de şiddetli olarak değerlendirildi. Korneal boyanma açısından
değerlendirildiğinde ise gözlerin %13,2’da normal boyanma, %39,6’de hafif
boyanma, %23,3’de orta derecede boyanma ve %23,9’da ise şiddetli boyanma
mevcuttu.

Sonuç: OYH'nın
teşhis edilmesinde, sadece OSDI anketinin kullanılmasının yanı sıra, gözyaşı
kalitesini ve stabilitesini gösteren testleri de içeren bir testin kullanılması
da sağlıklı olacaktır.

Keywords

Glokom, Antiglokomatöz İlaçlar, Oküler Yüzey Hastalığı

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