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Obstruktif Sleep Apne ve Erektil Disfonksiyon Arasındaki İlişki

Year 2019, Volume: 3 Issue: 2, 164 - 167, 23.08.2019
https://doi.org/10.30565/medalanya.504233

Abstract

Amaç: Obstruktif Sleep Apne Sendromu (OSAS) sık görülen uyku bozukluklarından biridir. Uykuda üst solunum yollarında parsiyel ya da tam obstrüksiyona bağlı gelişen, kronik intermitant hipoksi sonucu sistemik etkileri olan bir hastalıktır. Çalışmamızda OSAS tanısı almış hastalarda Erektil Disfonkiyon (ED) sıklığını saptamak amaçlandı. 

Yöntem: Çalışmamıza Ekim 2013- Aralık 2015 tarihleri arasında hastanemiz KBB polikliniğine horlama şikayeti ile başvurup polisomnografide OSAS tanısı alan 68 hasta dahil edildi. ED varlığını araştırmak için IIEF -15 (international index erectile dysfunction-15) anket formları dolduruldu. 

Bulgular: Çalışmadaki 68 erkek hastanın yaşları 25 ile 81 arasında, ortalama yaş 44.75±10,654 idi En düşük AHI değeri 5,1 en yüksek 82,4 ortalama 25.750± 23.226 idi (Tablo 1). IIEF 15 anketine göre çalışmaya katılan hastaların % 67.6 ‘sında ED saptandı. 













Sonuç: ED, OSAS’ın önemli bir komplikasyonudur ve erkek hastalar için önemli bir sağlık sorunudur. OSAS hastalarında ED mutlaka sorgulanmalıdır. 

References

  • 1. Hanak V, Jacobson DJ, McGree ME, Sauver JL, Lieber MM, Olson EJ, et al. Snoring as a Risk Factor for Sexual Dysfunction in Community Men J Sex Med. 2008 April; 5(4): 898–908. doi: 10.1111/j.1743-6109.2007.00706.x.
  • 2. Gürel A. Obstrüktif Uyku Apnre Sendromu İle Ürolojik Hastalıkların İlişkisi. Bozok Tıp Dergisi ;2018(8): 87-91.
  • 3. Lui K, Lui XS, Xiao L. NADPH Oxidase activation: A mechanism of erectile disfunction in a rat model of sleep apnea. J Androl 2012; 33:1186. doi: 10.2164/jandrol.112.016642.
  • 4. Perimenis P, Karkoulias K, Konstantinopoulos A, Perimeni PP, Katsenis G, Athanasopoulos A, et al. Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient's satisfaction with treatment. Asian J Androl. 2007 Mar;9(2):259-64. doi: 10.1111/j.1745-7262.2007.00085.x
  • 5. Margel D, Cohen M, Livne PM, Pillar G. Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology 2004; 3: 545-549. doi: 10.1016/j.urology.2003.10.016
  • 6. Gonçalves MA, Guilleminault C, Ramos E, Palha A, Paiva T. Erectile dysfunction, obstructive sleep apnea syndrome and nasal CPAP treatment. Sleep Medicine 2005; 6: 333-339. doi: 10.1016/j.sleep.2005.03.001
  • 7. Verratti V, DiGuilio C, Berardinelli F. The role of hypoxia in erectile dysfunction mechanisms. Int J ImpotRes 2007; 19:496. doi: 10.1038/sj.ijir.3901560
  • 8. Kim N, Vardi Y, Patma-Nathan H. Oxygen tension regulates the nitricoxide pathway. Physiological role in penileerection. J ClinInvest 1993; 91:437. doi: 10.1172/JCI116220
  • 9. Acar M, Kaya C, Çatlı T, Üre İ, Fidan H.S, Kaymakçı M. Obstruktif Uyku Apne Sendromu olan Erektil Disfonksiyonlu Erkek Hastalarda Polisomnografik Bulguların Analizi ve Nazal CPAP Tedavisinin Erektil Disfonksiyon Üzerine Etkisi. Bakırköy Tıp Dergisi, 2014,10(4). doi: 10.5350/BTDMJB201410404
  • 10. Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K, Mikami H, et al. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem Biophys Res Commun. 1990 Jun 29;169(3):973-7. doi: 10.1016/0006-291x(90)91989-6
  • 11. Budweiser S, Enderlein S, Jörres RA, Hitzl AP, Wieland WF, Pfeifer M, et al. Sleep apnea is an independent correlate of erectile and sexual dysfunction. J Sex Med. 2009 Nov;6(11):3147-57. doi: 10.1111/j.1743-6109.2009.01372.x.
  • 12. Shin HW, Rha YC, Han DH, Chung S, Yoon IY, Rhee CS,  et al. Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea. Int J Impot Res. 2008 Nov-Dec;20(6):549-53. doi: 10.1038/ijir.2008.39. 
  • 13. . Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, et al. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocrinol Metab. 2002 Jul;87(7):3394-8. doi: 10.1210/jcem.87.7.8663
  • 14. Campos-Juanatey F, Fernandez-Barriales M, Gonzalez M, Portillo-Martin JA. Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review. Asian J Androl 2017;19:303-10. doi: 10.4103/1008-682X.170440.
  • 15. Collard PH, Rodenstein DO. CPAP therapy. Eur Respir Mon 1998; 10: 179-204.
  • 16. Pascual M, de Batlle J, Barbé F, Castro-Grattoni AL, Auguet JM, Pascual L, et al. Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP). Plos One;2018(13): e0201930. doi: 10.1371/journal.pone.0201930.
  • 17. Fanfulla F, Malaguti S, Montagna T, Salvini S, Bruschi C,  Crotti P et al. Erectile dysfunction in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep. 2000 Sep 15;23(6):775-81. PMID: 11007444
  • 18. Mayer P, Dennatteis M, Pepin JL. Peripheral neuropathy in sleep apnea: a tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med 1999; 159: 213-219. doi: 10.1164/ajrccm.159.1.9709051
  • 19. McCowen KC, Malhotra A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men. Sleep Med 2003; 4: 83-84. doi: 10.1016/S1389-9457(02)00248-4
  • 20. Akashiba T, Kawahara S, Akahoshi S, Omori C, Saito O, Majima T et al. Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest 2002; 122: 861-865. doi: 10.1378/chest.122.3.861.
  • 21. Ahmet A. Systematic Reviews and Meta-Analyses Acta Med. Alanya 2018;2(2):62-63 [Turkish] DOI: 10.30565/medalanya.439541

Relationships between Erectile dysfunction and obstructive sleep apnea syndrome

Year 2019, Volume: 3 Issue: 2, 164 - 167, 23.08.2019
https://doi.org/10.30565/medalanya.504233

Abstract

Aim: Obstructive Sleep Apnea Syndrome (OSAS) is one of the common sleep disorders.  Chronic intermittent hypoxia due to partial or complete obstruction of the upper airways during sleep causes systemic effects. In our study, we aimed to determine the frequency of Erectile Dysfunction (ED) in patients with OSAS. 

Methods: Our study included 68 patients between October 2013 and December 2015 which the patient was admitted to the ENT outpatient clinic in our hospital with a complaint of snoring and diagnosed as OSAS by polysomnography. IIEF-15 (international index erectile dysfunction-15) questionnaire forms were completed to investigate the presence of ED. 

Results: The age of 68 male patients in the study are between 25 and 81 years, with a mean age of 44.75 ± 10.654. The lowest and highest AHI values were 5.1 and 82.4, respectively and average 25.750 ± 23.226 (Table 1). 67.6% of patients participating in the study had ED by according to the IIEF-15 survey. 













Conclusion: ED is an important complication of OSAS which is an important health problem for male patients. ED should be questioned in patients with OSAS. 

References

  • 1. Hanak V, Jacobson DJ, McGree ME, Sauver JL, Lieber MM, Olson EJ, et al. Snoring as a Risk Factor for Sexual Dysfunction in Community Men J Sex Med. 2008 April; 5(4): 898–908. doi: 10.1111/j.1743-6109.2007.00706.x.
  • 2. Gürel A. Obstrüktif Uyku Apnre Sendromu İle Ürolojik Hastalıkların İlişkisi. Bozok Tıp Dergisi ;2018(8): 87-91.
  • 3. Lui K, Lui XS, Xiao L. NADPH Oxidase activation: A mechanism of erectile disfunction in a rat model of sleep apnea. J Androl 2012; 33:1186. doi: 10.2164/jandrol.112.016642.
  • 4. Perimenis P, Karkoulias K, Konstantinopoulos A, Perimeni PP, Katsenis G, Athanasopoulos A, et al. Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient's satisfaction with treatment. Asian J Androl. 2007 Mar;9(2):259-64. doi: 10.1111/j.1745-7262.2007.00085.x
  • 5. Margel D, Cohen M, Livne PM, Pillar G. Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology 2004; 3: 545-549. doi: 10.1016/j.urology.2003.10.016
  • 6. Gonçalves MA, Guilleminault C, Ramos E, Palha A, Paiva T. Erectile dysfunction, obstructive sleep apnea syndrome and nasal CPAP treatment. Sleep Medicine 2005; 6: 333-339. doi: 10.1016/j.sleep.2005.03.001
  • 7. Verratti V, DiGuilio C, Berardinelli F. The role of hypoxia in erectile dysfunction mechanisms. Int J ImpotRes 2007; 19:496. doi: 10.1038/sj.ijir.3901560
  • 8. Kim N, Vardi Y, Patma-Nathan H. Oxygen tension regulates the nitricoxide pathway. Physiological role in penileerection. J ClinInvest 1993; 91:437. doi: 10.1172/JCI116220
  • 9. Acar M, Kaya C, Çatlı T, Üre İ, Fidan H.S, Kaymakçı M. Obstruktif Uyku Apne Sendromu olan Erektil Disfonksiyonlu Erkek Hastalarda Polisomnografik Bulguların Analizi ve Nazal CPAP Tedavisinin Erektil Disfonksiyon Üzerine Etkisi. Bakırköy Tıp Dergisi, 2014,10(4). doi: 10.5350/BTDMJB201410404
  • 10. Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K, Mikami H, et al. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem Biophys Res Commun. 1990 Jun 29;169(3):973-7. doi: 10.1016/0006-291x(90)91989-6
  • 11. Budweiser S, Enderlein S, Jörres RA, Hitzl AP, Wieland WF, Pfeifer M, et al. Sleep apnea is an independent correlate of erectile and sexual dysfunction. J Sex Med. 2009 Nov;6(11):3147-57. doi: 10.1111/j.1743-6109.2009.01372.x.
  • 12. Shin HW, Rha YC, Han DH, Chung S, Yoon IY, Rhee CS,  et al. Erectile dysfunction and disease-specific quality of life in patients with obstructive sleep apnea. Int J Impot Res. 2008 Nov-Dec;20(6):549-53. doi: 10.1038/ijir.2008.39. 
  • 13. . Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, et al. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocrinol Metab. 2002 Jul;87(7):3394-8. doi: 10.1210/jcem.87.7.8663
  • 14. Campos-Juanatey F, Fernandez-Barriales M, Gonzalez M, Portillo-Martin JA. Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review. Asian J Androl 2017;19:303-10. doi: 10.4103/1008-682X.170440.
  • 15. Collard PH, Rodenstein DO. CPAP therapy. Eur Respir Mon 1998; 10: 179-204.
  • 16. Pascual M, de Batlle J, Barbé F, Castro-Grattoni AL, Auguet JM, Pascual L, et al. Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP). Plos One;2018(13): e0201930. doi: 10.1371/journal.pone.0201930.
  • 17. Fanfulla F, Malaguti S, Montagna T, Salvini S, Bruschi C,  Crotti P et al. Erectile dysfunction in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep. 2000 Sep 15;23(6):775-81. PMID: 11007444
  • 18. Mayer P, Dennatteis M, Pepin JL. Peripheral neuropathy in sleep apnea: a tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med 1999; 159: 213-219. doi: 10.1164/ajrccm.159.1.9709051
  • 19. McCowen KC, Malhotra A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men. Sleep Med 2003; 4: 83-84. doi: 10.1016/S1389-9457(02)00248-4
  • 20. Akashiba T, Kawahara S, Akahoshi S, Omori C, Saito O, Majima T et al. Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest 2002; 122: 861-865. doi: 10.1378/chest.122.3.861.
  • 21. Ahmet A. Systematic Reviews and Meta-Analyses Acta Med. Alanya 2018;2(2):62-63 [Turkish] DOI: 10.30565/medalanya.439541
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Surgery
Journal Section Research Article
Authors

Hüseyin Günizi

Suat Avcı

Arif Kol This is me

Berna Devrim Yağbasan This is me

Publication Date August 23, 2019
Submission Date December 28, 2018
Acceptance Date March 20, 2019
Published in Issue Year 2019 Volume: 3 Issue: 2

Cite

Vancouver Günizi H, Avcı S, Kol A, Yağbasan BD. Obstruktif Sleep Apne ve Erektil Disfonksiyon Arasındaki İlişki. Acta Med. Alanya. 2019;3(2):164-7.

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