Research Article
BibTex RIS Cite

Akut pulmoner tromboembolide serum sodyum, kreatinin ve glukoz değerlerinin prognoza etkisi

Year 2019, Volume: 3 Issue: 3, 220 - 225, 26.10.2019
https://doi.org/10.30565/medalanya.558123

Abstract

Amaç: Pulmoner tromboemboli, mortalitesi ve morbiditesi yüksek olan bir hastalıktır. Bu çalışmada serum sodyum, glukoz ve kreatinin değerlerinin prognoz üzerine olan etkileri araştırılmıştır. 

Hastalar ve Yöntemler: Ocak 2010 ile Aralık 2012 tarihleri arasında PTE tanısı ile yatırılarak tedavi edilen hastaların verileri retrospektif olarak incelendi. Başvuru anındaki rutin laboratuvar değerleri, arteriyel kan gazı ve transtorasik ekokardiyografi sonuçları ile 30 günlük mortalite oranları kaydedildi. 

Bulgular: Her iki grup karşılaştırıldığında mortalitesi yüksek olan grubun ortalama serum sodyum düzeyi ve eGFR, diğer gruba göre anlamlı olarak daha düşükken, serum glukoz düzeyi daha yüksek saptandı. Bu belirteçlerin PESI ile uyumluluğu incelendiğinde ise PESI sınıf V’de diğer sınıflara göre serum sodyum düzeyinin ve eGFR’nin daha düşük, serum glukoz düzeyinin daha yüksek olduğu saptandı ve bu fark istatistiksel olarak anlamlı bulundu. 

Sonuç: Çalışmamızda, her merkezde kolaylıkla uygulanabilme avantajına sahip parametreler olan serum sodyum, glukoz ve eGFR düzeylerinin, akut PTE’de mortalite riskini belirlemede, daha önce etkinliği kanıtlanmış prognostik faktörler olan RVD, troponin ve PESI parametreleri ile uyumluluk gösterdikleri saptandı. 

References

  • 1. Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galie N, Pruszczyk P et al. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force fort he Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J. 2008;29(18):2276-315. PMID: 18757870
  • 2. Söhne M, Wolde M, Büller HR. Biomarkers in pulmonary embolism. Curr Opin Cardiol. 2004;19(6):558-62. PMID: 15502498
  • 3. Yalamanchili K, Sukhija R, Aronow WS. Prevalence of increased cardiac troponin I levels in patients with and without acute pulmonary embolism and relation of increased cardiac troponin I levels with in-hospital mortality in patients with acute pulmonary embolism. Am J Cardiol. 2004;93(2):263-4. PMID: 14715366
  • 4. Scherz N, Aujesky D, Mean M. Elevated admission glucose and mortality in patients with acute pulmonary embolism. Diabetes Care. 2012;35(1):25-31. PMID: 22074725
  • 5. Scherz N, Labarere J, Mean M, Ibrahim SA, Fine MJ, Aujesky D. Prognostic importance of hyponatremia in patients with acute pulmonary embolism. Am J Respir Crit Care Med. 2010;182(9):1178-83. PMID: 20595225
  • 6. Kostrubiec M, Labyk A, Pedowska-WIoszek J, Pacho S, Dzikowska-Diduch O, Dul P et al. Rapid improvement of renal function in patients with acute pulmonary embolism indicates favorable short term prognosis. Thromb Res. 2012;130(3):37-42. PMID: 22705059
  • 7. McCabe A, Hassan T, Doyle M, McCann B. Identification of patients with low-risk pulmonary embolism suitable for outpatient treatment using the pulmonary embolism severity index (PESI). Ir J Med Sci. 2013;182(2):291-5. PMID: 23188547
  • 8. Mikulewicz M, Lewczuk J. Importance of cardiac biomarkers in risk stratification in acute pulmonary embolism. Cardiol J. 2008;15(1):17-20. PMID: 18651380
  • 9. Conget F, Otero R, Jimenez D, Marti D, Escobar C, Rodriguez C et al. Short-term clinical outcome after acute symptomatic pulmonary embolism. Thromb Haemost 2008;100(5):937-42. PMID: 18989541
  • 10. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet 2009;373(9677): 1798-807. PMID: 19465235

Prognostic effect of serum sodium, glucose, creatinine in patients with acute pulmonary thromboembolism

Year 2019, Volume: 3 Issue: 3, 220 - 225, 26.10.2019
https://doi.org/10.30565/medalanya.558123

Abstract

Aim: Pulmonary thromboembolism is a disease with high mortality and morbidity. In this study, the impacts of serum sodium, glucose and creatinine levels on prognosis were investigated. 

Patients and Methods: The data of the patients with PTE who received treatment between January 2010 and December 2012 were analyzed retrospectively. Routine laboratory values, arterial blood gas and transthoracic echocardiography results at the time of admission and 30-day mortality rates were recorded. 

Results: The mean serum sodium level and eGFR in the group with high mortality were significantly lower compared to the other group, while the serum glucose level was higher. When the compatibility of these markers with PESI was examined, it was found that serum sodium level and eGFR were lower and serum glucose level was higher in PESI class V compared to the other classes, and this difference was statistically significant. 

Conclusion: In this study, it was found that serum sodium, glucose and eGFR levels, which have the advantage of availability in every center, were compatible with RVD, troponin and PESI parameters that were previously proven prognostic factors in determining the mortality risk in acute PTE. 

References

  • 1. Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galie N, Pruszczyk P et al. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force fort he Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J. 2008;29(18):2276-315. PMID: 18757870
  • 2. Söhne M, Wolde M, Büller HR. Biomarkers in pulmonary embolism. Curr Opin Cardiol. 2004;19(6):558-62. PMID: 15502498
  • 3. Yalamanchili K, Sukhija R, Aronow WS. Prevalence of increased cardiac troponin I levels in patients with and without acute pulmonary embolism and relation of increased cardiac troponin I levels with in-hospital mortality in patients with acute pulmonary embolism. Am J Cardiol. 2004;93(2):263-4. PMID: 14715366
  • 4. Scherz N, Aujesky D, Mean M. Elevated admission glucose and mortality in patients with acute pulmonary embolism. Diabetes Care. 2012;35(1):25-31. PMID: 22074725
  • 5. Scherz N, Labarere J, Mean M, Ibrahim SA, Fine MJ, Aujesky D. Prognostic importance of hyponatremia in patients with acute pulmonary embolism. Am J Respir Crit Care Med. 2010;182(9):1178-83. PMID: 20595225
  • 6. Kostrubiec M, Labyk A, Pedowska-WIoszek J, Pacho S, Dzikowska-Diduch O, Dul P et al. Rapid improvement of renal function in patients with acute pulmonary embolism indicates favorable short term prognosis. Thromb Res. 2012;130(3):37-42. PMID: 22705059
  • 7. McCabe A, Hassan T, Doyle M, McCann B. Identification of patients with low-risk pulmonary embolism suitable for outpatient treatment using the pulmonary embolism severity index (PESI). Ir J Med Sci. 2013;182(2):291-5. PMID: 23188547
  • 8. Mikulewicz M, Lewczuk J. Importance of cardiac biomarkers in risk stratification in acute pulmonary embolism. Cardiol J. 2008;15(1):17-20. PMID: 18651380
  • 9. Conget F, Otero R, Jimenez D, Marti D, Escobar C, Rodriguez C et al. Short-term clinical outcome after acute symptomatic pulmonary embolism. Thromb Haemost 2008;100(5):937-42. PMID: 18989541
  • 10. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet 2009;373(9677): 1798-807. PMID: 19465235
There are 10 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Research Article
Authors

Aliye Gamze Calis 0000-0002-1629-7852

Aliye Candan Ogus This is me 0000-0001-9371-4288

Publication Date October 26, 2019
Submission Date April 26, 2019
Acceptance Date June 22, 2019
Published in Issue Year 2019 Volume: 3 Issue: 3

Cite

Vancouver Calis AG, Ogus AC. Prognostic effect of serum sodium, glucose, creatinine in patients with acute pulmonary thromboembolism. Acta Med. Alanya. 2019;3(3):220-5.

9705

This Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.