Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels

Year 2020, Volume: 4 Issue: 1, 10 - 15, 02.03.2020

Abdurrahman Erdem Basaran Aslınur Sırcan-küçüksayan Murat Canpolat Sevtap Velipasaoğlu

https://doi.org/10.30565/medalanya.569972

Abstract

Aim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels.

Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnosed by a physician as having scrotal hyperpigmentation and 18 with normal scrotal pigmentation, who were admitted for the evaluation of prolonged jaundice. Age, gestational week, birth weight and scrotal pigmentation noted by the physician were recorded. Spectral data were acquired from scrotum and thigh. A correlation between the spectral measurements and the blood 17-hydroxyprogesterone level was determined by comparing spectral value in the wavelength range of 620-800 nm and 17-hydroxyprogesterone levels.

Results: No statistically significant difference was observed between the groups who were categorized by the physician as having “hyperpigmented” or “normal” scrotal color in terms of the infant’s age, gestational week, birth weight, 17-hydroxyprogesterone level or spectrometric values. We observed a strong correlation between 17-hydroxyprogesterone levels and spectrometric values in all groups.

Conclusion: This preliminary study is the first one in the literature which evaluates scrotal pigmentation with an objective spectrometric method and determines its relationship with 17-hydroxyprogesterone levels. Further studies are needed to employ this method as a non-invasive, indirect screening test for the screening of congenital adrenal hyperplasia in male infants.

Keywords

Congenital adrenal hyperplasia, spectrometry, scrotal pigmentation, 17-hydroxyprogesterone, spectroscopic method

Supporting Institution

Akdeniz University Scientific Research Unit, Antalya, Turkey

Project Number

2014.04.0103.005

Yenidoğanlarda skrotal pigmentasyonun spektrometre ile değerlendirilmesi ve 17-hidroksiprogesteron kan düzeyi ile korelasyonunun incelenmesi

Abstract

Amaç: Spektrometre ile bebeklerin skrotal melanin dansitesini değerlendirmek ve spektrometrik değerlendirme ile fizik muayene ve kan 17-hidroksiprogesteron düzeyleri arasındaki ilişkiyi belirlemektir.

Gereç ve Yöntemler: Çalışmaya skrotal hiperpigmentasyonu olduğu düşünülen 22 olgu ile uzamış sarılık nedeniyle başvuran normal skrotal pigmentasyona sahip 18 olgu olmak üzere toplam 40 bebek dahil edildi. Olguların yaşı, gestasyon haftası, doğum ağırlığı, anne yaşı, skrotum rengi kayıt altına alındı. Spektral veriler skrotumdan ve uyluktan elde edildi. Spektral ölçümler ve kan 17- hidroksiprogesteron seviyesi arasındaki korelasyon, 620-800 nm dalga boyu aralığındaki spektral değer ve 17- hidroksiprogesteron seviyelerinin karşılaştırılmasıyla incelendi.

Bulgular: Skrotal hiperpigmentasyonu saptanan ve saptanmayan grup arasında anne-olgu yaşı, gestasyon haftası, doğum ağırlığı, 17-hidroksiprogesteron düzeyi ve spektrometri değeri arasında istatistiksel olarak anlamlı farklılık saptanmadı. Tüm gruplarda 17-hidroksiprogesteron düzeyleri ile spektrometrik değerler arasında güçlü bir korelasyon gözlemledik.

Sonuç: Çalışmamız, literatürde spektrometre değerleriyle skrotal pigmentasyonun nesnel bir ölçüt hale getirildiği, 17-hidroksiprogesteron ile ilişkisinin incelendiği, gelecekte erkek bebeklerde konjenital adrenal hiperplazi taramasına dolaylı yoldan yardımcı olabilecek bir çalışmadır.

Keywords

Konjenital adrenal hiperplazi, spektrometre, skrotal pigmentasyon, 17-hidroksiprogesteron, spektroskopik yöntem

Project Number

2014.04.0103.005

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