Research Article
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Spontan regresyon gösteren disk herniasyonları

Year 2023, Volume: 7 Issue: 1, 53 - 58, 21.06.2023
https://doi.org/10.30565/medalanya.1217069

Abstract

Amaç: Vertebral disk hernileri sık görülen bir klinik durumdur. Cerrahiye gitmeden iyileşen vakalar vardır. Spontan regresyon gösteren disk hernilerini istatistiksel olarak anlamlı şekilde ortaya koyan bir toplu çalışma yapılmamıştır. Amacımız, cerrahi endikasyona rağmen, spontan regresyon gösteren disk hernisi vakalarını belirleyip istatistiksel olarak anlamlı şekilde ortaya koymaktır.

Yöntemler: Bu amaçla, 4,5 yıldır beyin cerrahisine gelen 2700 hastanın dosyalarından retrospektif kohort yapıldı. 341 hastaya cerrahi endikasyon kondu. 323 hasta opere edildi. Cerrahi endikasyona rağmen ameliyat olmayan 18 hastaya fizik tedavi, ilaç tedavisi, istirahat önerildi. 18 hastanın kontrol MRG sonuçlarına göre disk hernilerinin spontan gerilediği belirlendi. İnsidans, rölatif risk (RR), atfedilen risk (AR) ve korunabilirlik hızı hesaplandı. Demografik değerler için SPSS’de ortalamaların karşılaştırılması kullanıldı. Ki-kare testi yapıldı. P<0,05 istatistiki olarak anlamlı kabul edildi.

Bulgular: Disk herrnisi spontan regresyon gösterenlerin yaş ortalaması 46,4 idi. Yaş olarak iki grupta istatistiki olarak anlamlı bir fark yoktu (P>0,05). En fazla spontan regresyon Lumbal 5 Sakral 1’de görüldü. 4,5 yıl için vertebral disk hernisi insidansı % 12.62 bulundu. Rölatif risk, 1.06 bulundu. Cerrahi uygulananlarda, pozitif etken olarak cerrahi girişimin % 94 hastada tam iyileşme olduğu belirlendi. Negatif etken olarak, cerrahi endikasyon olduğu halde cerrahi yapılmayan, istirahat, medikal ve fizik tedavi uygulananlarda tam iyileşme %100’dü. Cerrahi endikasyonu olup, cerrahi yapılanlar %94,42, cerrahisiz spontan regresyona gidenler %5,57 bulundu. Cerrahi gitmeyenlerin tüm hastalar içindeki yüzdesi % 0,66 idi. Disk hernilerinde, cerrahisiz spontan regresyon düşünülmesi istatistiki olarak anlamlı bulundu (p<0,05).

Sonuç: Uygun klinik takipteki disk hernilerinde cerrahi tedaviden önce spontan regresyon ihtimalinin göz önünde bulundurulmalı, vücudun iyileşme yönünde inflamatuar yanıtına zaman verilmelidir

Supporting Institution

Yok.

Project Number

Yok

Thanks

Yok

References

  • 1. Kim SG, Yang JC, Kim TW, Park KH. Spontaneous regression of extruded lumbar disc herniation: three cases report. Korean J Spine. 2013;10(2):78-81. doi: 10.14245/kjs.2013.10.2.78.
  • 2. Çitişli V, İbrahimoğlu M. Spontaneous remission of a big subligamentous extruded disc herniation: case report and review of the literature. Korean J Spine. 2015;12(1):19-21. doi: 10.14245/kjs.2015.12.1.19.
  • 3. Ribeiro RP, Matos RM, Vieira A, Costa JM, Proença R, Pinto R. Spontaneous regression of symptomatic lumbar disc herniation. Acta Reumatol Port. 2011;36(4):396-8. PMID: 22472931.
  • 4. Greenberg MS. Hand book of Neurosurgery. 6th edition. Thieme medical Publisher 2006:289-312.
  • 5. Kuruoğlu E, Marangoz AH, Aydın K, Çokluk C.Spontaneous regression in herniated lumbar disc. Journal of Experimental and Clinical Medicine 2013;30:103-5 doi: 10.5835/jecm.omu.30.s1.017
  • 6. Mixter WJ, Barr JS. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 1934;211:210-5. doi: 10.1056/NEJM193408022110506
  • 7. Slavin KV, Raja A, Thornton J, Wagner FC Jr. Spontaneous regression of a large lumbar disc herniation: report of an illustrative case. Surg Neurol. 2001;56(5):333-6; discussion 337. doi: 10.1016/s0090-3019(01)00607-3.
  • 8. Reddy PK, Sathyanarayana S, Nanda A. MRI-documented spontaneous regression of cervical disc herniation: a case report and review of the literature. J La State Med Soc. 2003;155(2):97-8. PMID: 12778993.
  • 9. Westmark RM, Westmark KD, Sonntag VK. Disappearing cervical disc. Case report. J Neurosurg. 1997;86(2):289-90. doi: 10.3171/jns.1997.86.2.0289.
  • 10. Yang X, Zhang Q, Hao X, Guo X, Wang L. Spontaneous regression of herniated lumbar discs: Report of one illustrative case and review of the literature. Clin Neurol Neurosurg. 2016;143:86-9. doi: 10.1016/j.clineuro.2016.02.020.
  • 11. KayaE, Ozyurek S, Kaplan C, Gokcen B,Kose O. Regression of an extruded lumbardisc herniation after thermo mechanical massage bed therapy, OA Orthopaedics 2013;1(2):15.doi: 10.13172/2052-9627-1-2-769
  • 12. Albayrak S, Durdağ E, Atçı İB, Ayden Ö.Rapid Spontaneus Regression of Lumbar Disc Herniation Accompanying Neurological Recovery: Case Report. J PMR Sci. 2012;15: 89-91.
  • 13. Gezici AR, Ergün R. Spontaneous regression of a huge subligamentous extruded disc herniation: short report of an illustrative case. Acta Neurochir (Wien). 2009;151(10):1299-300. doi: 10.1007/s00701-009-0370-x.
  • 14. Macki M, Hernandez-Hermann M, Bydon M, Gokaslan A, McGovern K, Bydon A. Spontaneous regression of sequestrated lumbar disc herniations: Literature review. Clin Neurol Neurosurg. 2014;120:136-41. doi: 10.1016/j.clineuro.2014.02.013.
  • 15. . Orief T, Orz Y, Attia W, Almusrea K. Spontaneous resorption of sequestrated intervertebral disc herniation. World Neurosurg. 2012 Jan;77(1):146-52. doi: 10.1016/j.wneu.2011.04.021.
  • 16. Autio RA, Karppinen J, Niinimaki J, Ojala R, Kurunlahti M, Haapea M, et al.Determinants of spontaneous resorption of intervertebral disc herniations. Spine (Phila Pa 1976). 2006;31(11):1247-52. doi: 10.1097/01.brs.0000217681.83524.4a.
  • 17. Kobayashi S, Meir A, Kokubo Y, Uchida K, Takeno K, Miyazaki T, et al.Ultrastructural analysis on lumbar disc herniation using surgical specimens: role of neovascularization and macrophages in hernias. Spine (Phila Pa 1976). 2009 Apr 1;34(7):655-62. doi: 10.1097/BRS.0b013e31819c9d5b.
  • 18. Yoshida M, Nakamura T, Sei A, Kikuchi T, Takagi K, Matsukawa A.Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. Spine (Phila Pa 1976). 2005;30(1):55-61. doi: 10.1097/01.brs.0000149194.17891.bf.
  • 19. Cunha C, Silva AJ, Pereira P, Vaz R, Gonçalves RM, Barbosa MA. The inflammatory response in the regression of lumbar disc herniation. Arthritis Res Ther. 2018;20(1):251. doi: 10.1186/s13075-018-1743-4.

Disc herniations with spontaneous regression

Year 2023, Volume: 7 Issue: 1, 53 - 58, 21.06.2023
https://doi.org/10.30565/medalanya.1217069

Abstract

Aim: Vertebral disc hernias are a common clinical condition. There are reported cases of recovery without surgery. However, no collective study has yet been conducted to reveal spontaneously regressing disc hernias statistically significant. Our aim is to determine the cases of spontaneous regression disc herniation and to reveal statistically significant and to reveal the chance of spontaneous regression without surgery.

Methods: For this purpose, a retrospective cohort was made from the files of 2,700 patients who came to our clinic during a period of 4.5 years. Surgical indication was determined in 341 patients and 323 patients were operated on. Physical and drug therapy as well as rest were recommended to 18 patients. These 18 patients who did not receive surgical treatment, it was determined that the disc hernias had spontaneous regression. Incidence, relative risk (RR), attributable risk (AR), and rate of protection were calculated. Comparison of the means in the SPSS and Chi-square test.

Results: The most spontaneously regressed disc herniation was determined as L5S1 level. In those treated surgically, surgical intervention as a positive factor was found to provide complete recovery in 94% of patients. Surgery indication determined that 94.42% of those who had surgery were indicated and those who did not undergo surgery and went to spontaneous regression, represented 5.57%. Spontaneous regression of disc hernias without surgery was found to be statistically significant (p<0.05).

Conclusion: It is important to consider the possibility of spontaneous regression before surgical treatment in disc herniations. In disc herniation, time should be allocated for the body's inflammatory response to heal.

Project Number

Yok

References

  • 1. Kim SG, Yang JC, Kim TW, Park KH. Spontaneous regression of extruded lumbar disc herniation: three cases report. Korean J Spine. 2013;10(2):78-81. doi: 10.14245/kjs.2013.10.2.78.
  • 2. Çitişli V, İbrahimoğlu M. Spontaneous remission of a big subligamentous extruded disc herniation: case report and review of the literature. Korean J Spine. 2015;12(1):19-21. doi: 10.14245/kjs.2015.12.1.19.
  • 3. Ribeiro RP, Matos RM, Vieira A, Costa JM, Proença R, Pinto R. Spontaneous regression of symptomatic lumbar disc herniation. Acta Reumatol Port. 2011;36(4):396-8. PMID: 22472931.
  • 4. Greenberg MS. Hand book of Neurosurgery. 6th edition. Thieme medical Publisher 2006:289-312.
  • 5. Kuruoğlu E, Marangoz AH, Aydın K, Çokluk C.Spontaneous regression in herniated lumbar disc. Journal of Experimental and Clinical Medicine 2013;30:103-5 doi: 10.5835/jecm.omu.30.s1.017
  • 6. Mixter WJ, Barr JS. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 1934;211:210-5. doi: 10.1056/NEJM193408022110506
  • 7. Slavin KV, Raja A, Thornton J, Wagner FC Jr. Spontaneous regression of a large lumbar disc herniation: report of an illustrative case. Surg Neurol. 2001;56(5):333-6; discussion 337. doi: 10.1016/s0090-3019(01)00607-3.
  • 8. Reddy PK, Sathyanarayana S, Nanda A. MRI-documented spontaneous regression of cervical disc herniation: a case report and review of the literature. J La State Med Soc. 2003;155(2):97-8. PMID: 12778993.
  • 9. Westmark RM, Westmark KD, Sonntag VK. Disappearing cervical disc. Case report. J Neurosurg. 1997;86(2):289-90. doi: 10.3171/jns.1997.86.2.0289.
  • 10. Yang X, Zhang Q, Hao X, Guo X, Wang L. Spontaneous regression of herniated lumbar discs: Report of one illustrative case and review of the literature. Clin Neurol Neurosurg. 2016;143:86-9. doi: 10.1016/j.clineuro.2016.02.020.
  • 11. KayaE, Ozyurek S, Kaplan C, Gokcen B,Kose O. Regression of an extruded lumbardisc herniation after thermo mechanical massage bed therapy, OA Orthopaedics 2013;1(2):15.doi: 10.13172/2052-9627-1-2-769
  • 12. Albayrak S, Durdağ E, Atçı İB, Ayden Ö.Rapid Spontaneus Regression of Lumbar Disc Herniation Accompanying Neurological Recovery: Case Report. J PMR Sci. 2012;15: 89-91.
  • 13. Gezici AR, Ergün R. Spontaneous regression of a huge subligamentous extruded disc herniation: short report of an illustrative case. Acta Neurochir (Wien). 2009;151(10):1299-300. doi: 10.1007/s00701-009-0370-x.
  • 14. Macki M, Hernandez-Hermann M, Bydon M, Gokaslan A, McGovern K, Bydon A. Spontaneous regression of sequestrated lumbar disc herniations: Literature review. Clin Neurol Neurosurg. 2014;120:136-41. doi: 10.1016/j.clineuro.2014.02.013.
  • 15. . Orief T, Orz Y, Attia W, Almusrea K. Spontaneous resorption of sequestrated intervertebral disc herniation. World Neurosurg. 2012 Jan;77(1):146-52. doi: 10.1016/j.wneu.2011.04.021.
  • 16. Autio RA, Karppinen J, Niinimaki J, Ojala R, Kurunlahti M, Haapea M, et al.Determinants of spontaneous resorption of intervertebral disc herniations. Spine (Phila Pa 1976). 2006;31(11):1247-52. doi: 10.1097/01.brs.0000217681.83524.4a.
  • 17. Kobayashi S, Meir A, Kokubo Y, Uchida K, Takeno K, Miyazaki T, et al.Ultrastructural analysis on lumbar disc herniation using surgical specimens: role of neovascularization and macrophages in hernias. Spine (Phila Pa 1976). 2009 Apr 1;34(7):655-62. doi: 10.1097/BRS.0b013e31819c9d5b.
  • 18. Yoshida M, Nakamura T, Sei A, Kikuchi T, Takagi K, Matsukawa A.Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. Spine (Phila Pa 1976). 2005;30(1):55-61. doi: 10.1097/01.brs.0000149194.17891.bf.
  • 19. Cunha C, Silva AJ, Pereira P, Vaz R, Gonçalves RM, Barbosa MA. The inflammatory response in the regression of lumbar disc herniation. Arthritis Res Ther. 2018;20(1):251. doi: 10.1186/s13075-018-1743-4.
There are 19 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Research Article
Authors

Veli Çıtışlı 0000-0002-1631-3795

Project Number Yok
Early Pub Date May 28, 2023
Publication Date June 21, 2023
Submission Date December 13, 2022
Acceptance Date March 31, 2023
Published in Issue Year 2023 Volume: 7 Issue: 1

Cite

Vancouver Çıtışlı V. Disc herniations with spontaneous regression. Acta Med. Alanya. 2023;7(1):53-8.

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