Şizofreni Hastalarında Serum Ürik Asit, Serum Ürik Asit Kreatinin Ranlarının Hastalık Şiddeti Ve Metabolik Sendrom İle İlişkisi

Year 2024, Volume: 8 Issue: 2, 122 - 128, 30.08.2024

Merve Akkuş , Kader Semra Karataş , Onur Gökçen , Feyza Dönmez , Çağla Özdemir

https://doi.org/10.30565/medalanya.1486564

Abstract

Amaç: Bu araştırmanın amacı çok yönlü etiyopatogeneze sahip şizofrenide serum ürik asit (SUA) ve serum ürik asit/kreatinin oranı (SUA/Cre) ile hastalık şiddeti ve metabolik sendrom arasındaki ilişkiyi incelemektir.

Yöntem: Çalışmaya 120'si sağlıklı kontrol ve 120'si şizofreni hastası olmak üzere toplam 240 katılımcı dahil edilmiştir. Sosyodemografik, klinik ve laboratuvar verileri toplandı, kriterlere göre metabolik sendrom durumu değerlendirildi. SUA ve kreatinin düzeyleri ölçülmüş ve SUA/Cre oranı hesaplanmıştır. Hastalığın şiddeti Pozitif ve Negatif Sendrom Ölçeği (PANSS) kullanılarak değerlendirilmiştir. Korelasyon ve ilişkileri tespit etmek için istatistiksel analizler yapılmıştır.

Bulgular: SUA düzeyleri ve SUA/Cre oranı şizofreni hastalarında kontrol grubuna göre daha yüksekti (sırasıyla p=0.14, p=0.010). SUA/Cre oranı PANSS negatif skoru ile pozitif korelasyon gösterdi (r=0.266,p=0.03). SUA düzeyleri, metabolik sendromu da olan şizofreni tanılı bireylerde, metabolik sendromu olmayanlara kıyasla daha yüksekti (p=0.009). Doğrusal regresyon analizleri, SUA düzeyleri ve SUA/Cre oranı ile şizofreni arasındaki ilişkinin cinsiyet, yaş, metabolik sendrom, BMI ve sigara içmenin etkileri sabitlendiğinde de devam ettiğini göstermiştir.

Sonuç: Bu çalışma, şizofreni tanısı almış bireylerde SUA ve SUA/Cre oranının hastalık şiddeti ve metabolik sendrom ile ilişkisini vurgulamaktadır.

Keywords

Şizofreni, Ürik asit, Ürik asit kreatinin oranı, Metabolik sendrom, Hastalık şiddeti

The Relationship of Serum Uric Acid, Serum Uric Acid Creatinine Ratios With Disease Severity and Metabolic Syndrome in Schizophrenia Patients

Abstract

Aim: The objective of this research was to examine the association between serum uric acid (SUA) and serum uric acid/creatinine ratio (SUA/Cre), disease severity and metabolic syndrome in schizophrenia with a multifaceted etiopathogenesis.

Methods: The study comprised 240 participants in total, 120 of whom were healthy controls and 120 of whom were schizophrenia patients. Sociodemographic, clinical and laboratory data was collected and metabolic syndrome was assessed according to the established criteria. SUA and creatinine levels were measured and the SUA/Cre ratio was calculated. The severity of the disease was evaluated utilizing the Positive and Negative Syndrome Scale (PANSS). Statistical analyses were conducted to ascertain correlations and associations.

Results: SUA levels and SUA/Cre ratio higher in schizophrenia patients than controls (p=0.14, p=0.010, respectively). SUA/Cre ratio was positively correlated with PANSS negative score (r=0.266, p=0.03). SUA levels were elevated in individuals diagnosed with schizophrenia who also had metabolic syndrome, in comparison to those who did not have metabolic syndrome (p=0.009). Linear regression analyses showed that the association between SUA levels and SUA/Cre ratio and schizophrenia persisted when the effects of gender, age, metabolic syndrome, BMI and smoking were fixed.

Conclusions: This study highlights the association of SUA and SUA/Cre ratio with disease severity and metabolic syndrome among individuals diagnosed with schizophrenia.

Keywords

Schizophrenia, Uric acid, Uric acid creatinine ratio, Metabolic syndrome, Disease severity

Ethical Statement

The research received approval from the Ethics Committee of XXX University (2023/01-24). Each participant provided written informed permission to participate in this research.

Supporting Institution

None

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