Retrospective Comparison of Age-Related Efficacy and Cost of Sugammadex and Neostigmine in Obese Female Patients Undergoing Elective Surgery

Year 2024, Volume: 8 Issue: 3, 175 - 180, 30.12.2024

Miraç Alasu , Filiz Alkaya Solmaz

https://doi.org/10.30565/medalanya.1514454

Abstract

Aim: The purpose of the study is to compare the clinical impact and cost of sugammadex and neostigmine in obese, young-elderly patients.

Materials and Methods: In this study, the medical and anesthesia records of patients whose operation did not exceed 150 minutes and who used rocuronium as a muscle relaxant were evaluated retrospectively. Patients whose files were examined were divided into 4 groups according to age and drug given; Group YS: 2 mg/kg sugammadex between 20–60 years, Group ES: 2 mg/kg sugammadex between 60-80years, Group YN: 0.04 mg/kg neostigmin + 0.01 mg/kg atropine between 20–60 years, Group EN: 0.04 mg/kg neostigmin + 0.01 mg/kg atropine between 60–80 years. Time of TOF 25, 75, 90 recovery scores were recorded from the anesthesia records of the patients.

Results: Regarding the time to reach TOF 25,75,90, it was seen that the patients in Group YS and Group ES reached faster TOF values than Group YN and Group EN ( p<0,05). Compared with neostigmine, patients who were given sugammadex in the same age group were found to have faster recovery time and statistically significant differences (p<0,05).

Conclusion: Sugammadex provides rapid and effective reversal of moderate neuromuscular block compared to neostigmine, with a very low incidence of side effects and faster recovery times.

Keywords

Neostigmine, Obesity, Sugammadex, Tof, Age

Elektif Cerrahi Uygulanan Obez Kadın Hastalarda Sugammadeks ve Neostigminin Yaşa Bağlı Etkinlik ve Maliyetinin Retrospektif Olarak Karşılaştırılması

Abstract

Amaç: Çalışmanın amacı, obez, genç-yaşlı hastalarda sugammadeks ve neostigminin klinik etkisini ve maliyetini karşılaştırmaktır.

Gereç ve Yöntemler: Bu çalışmada, ameliyat süresi 150 dakikayı geçmeyen ve kas gevşetici olarak rokuronyum kullanılan hastaların tıbbi ve anestezi kayıtları retrospektif olarak değerlendirildi. Dosyaları incelenen hastalar yaş ve verilen ilaca göre 4 gruba ayrıldı; Grup YS: 20-60 yaş arası 2mg/kg sugammadeks, Grup ES: 60-80 yaş arası 2mg/kg sugammadeks, Grup YN: 20-60 yaş arası 0,04 mg/kg neostigmin + 0,01 mg/kg atropin, Grup EN: 60-80 yaş arası 0,04 mg/kg neostigmin + 0,01 mg/kg atropin. TOF 25,75,90 zamanı, derlenme skorları hastaların anestezi kayıtlarından kaydedildi.

Bulgular: TOF 25,75,90'a ulaşma süreleri açısından Grup YS ve Grup ES'deki hastaların Grup YN ve Grup EN'ye göre daha hızlı TOF değerlerine ulaştığı görüldü. (p<0,05). Neostigmin ile karşılaştırıldığında, aynı yaş grubunda sugammadeks verilen hastaların daha hızlı iyileşme süresine sahip olduğu ve istatistiksel olarak anlamlı farklılıklar olduğu bulundu (p<0,05).

Sonuç: Sugammadeks, neostigmine göre orta dereceli nöromüsküler bloğun hızlı ve etkili geri dönüşümünü sağlamakla birlikte, çok düşük yan etki insidansına ve daha hızlı iyileşme sürelerine sahiptir.

Keywords

Neostigmin, Obezite, Sugammadeks, TOF, Yaş

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