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Year 2014, Volume: 1 Issue: 1, 34 - 47, 16.12.2014

Abstract

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References

  • Mocellin S. Vitamin D and cancer: Deciphering the truth. Biochimica et Biophysica Acta 1816 (2011) 172–178
  • Krishnan AV, Feldman D, Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.Annu. Rev. Pharmacol. Toxicol. 2011;51:311-36.
  • Peterlik M, Cross HS, Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur. J. Clin. Nutr. 63 (2009) 1377–1386.
  • Garland F, Gorham ED, Mohr SB, Garland FC, Vitamin D for cancer prevention: global perspective.Ann. Epidemiol. 19 (2009) 468–483
  • Krishnan AV, Trump DL, Johnson CS, Feldman D, The role of vitamin D in cancer prevention and treatment. Endocrinol. Metab. Clin. North Am. 39 (2010) 401–418.
  • Deeb KK, Trump DL, Johnson CS, Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.Nat. Rev. Cancer 7 (2007) 684–700.
  • Campbell MJ, Elstner E, Holden S, Uskokovic M, Koeffler HP, Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.J. Mol. Endocrinol.19 (1997) 15–27.
  • Holick MF,The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 29(6) (2008): 361–8.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2011) ;96(7):1911–30.
  • Adams JS and Hewison M, Update in Vitamin D. J Clin Endocrinol Metab (2010);95(2): 471–478.
  • Holick MF, Vitamin D Deficiency. N Engl J Med 357: 266–281.Metab (2007);95(2): 471–478.
  • Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, et al. The nonskeletal effects of vitamin D: an Endocrine Society Scientific statement. Endocr Rev (2012);33(3): 456–92.
  • Giovannucci E, Expanding roles of vitamin D. J Clin Endocrinol Metab 2009;94: 418–420.
  • Garland CF, Gorham ED, Mohr SB, Garland FC,Vitamin D for cancer prevention: global perspective. Ann Epidemiol (2009);19: 468–483.
  • Hossein-Nezhad A, Spira A, Holick MF. Influence of vitamin d status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.PLoS One. 2013;8(3):e58725. doi:10.1371/journal.pone.0058725
  • Yang ES, Burnstein KL, Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. J. Biol. Chem. 278 (2003) 46862–46868.
  • Verlinden L, Verstuyf A, Convents R, Marcelis S, Van Camp M, Bouillon R, Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells.Mol.Cell. Endocrinol. 142 (1998) 57–65.
  • Jensen SS, Madsen MW, Lukas J, Binderup L, Bartek J, Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery.Mol. Endocrinol. 15 (2001) 1370–1380.
  • Boyle BJ, Zhao XY, Cohen P, Feldman D, Insulin-like growth factor binding protein-3 mediates 1 alpha,25-dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1. J. Urol. 165 (2001) 1319–1324.
  • Peng L, Malloy PJ, Feldman D, Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.Mol. Endocrinol. 18 (2004) 1109–1119.
  • Palmer HG, Sanchez-Carbayo M, Ordonez-Moran P, Larriba MJ, Cordon-Cardo C, Munoz A, Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.Cancer Res. 63 (2003) 7799–7806.
  • Li P, Li C, Zhao X, Zhang X, Nicosia SV, Bai W, p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase.J. Biol. Chem. 279 (2004)25260–25267
  • Ma Y, Yu WD, Hershberger PA, Flynn G, Kong RX, Trump DL, Johnson CS, 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model.Mol. Cancer Ther. 7 (2008) 3047–3055.
  • Blutt SE, McDonnell TJ, Polek TC, Weigel NL, Endocrinology 141 (2000) 10–17.
  • Narvaez CJ, Welsh J, Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells.J. Biol. Chem. 276 (2001) 9101–9107
  • Jiang F, Bao J, Li P, Nicosia SV, Bai W, Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase.J. Biol. Chem. 279 (2004) 53213–53221.
  • Hoyer-Hansen M, Nordbrandt SP, Jaattela M, Autophagy as a basis for the health-promoting effects of vitamin D.Trends Mol. Med. 16 (2010) 295–302.
  • Pan L, Matloob AF, Du J, Pan H, Dong Z, Zhao J, Feng Y, Zhong Y, Huang B, Lu J, Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.FEBS J. 277 (2010) 989–999.
  • Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE, Circ. Res. 87(2000) 214–220.
  • Ben-Shoshan M, Amir S, Dang DT, Dang LH, Weisman Y, Mabjeesh NJ, Mol. 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells.Cancer Ther. 6 (2007) 1433–1439.
  • Chung I, Han G, Seshadri M, Gillard BM, Yu WD, Foster BA, Trump DL, Johnson CS, Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo.Cancer Res. 69 (2009) 967–975.
  • Bao BY, Yao J, Lee YF, 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.Carcinogenesis 27 (2006) 1883–1893.
  • Aparna R, Subhashini J, Roy KR, Reddy GS, Robinson M, Uskokovic MR, Venkateswara Reddy G, Reddanna P, Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. J. Cell. Biochem. 104 (2008) 1832–1842.
  • Agarwal S, Reddy GV, Reddanna P, Eicosanoids in inflammation and cancer: the role of COX-2. Expert Rev. Clin. Immunol. 5 (2009)145–165.
  • Chung I, Wong MK, Flynn G, Yu WD, Johnson CS, Trump DL, Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells.Cancer Res. 66 (2006) 8565–8573.
  • Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, Kuo WL, Gray JW, Pinkel D, Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene.Nat. Genet. 25 (2000) 144–146.
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  • Gonzalez-Sancho JM, Alvarez-Dolado M, Munoz A, 1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells. FEBS Lett. 426 (1998) 225–228.
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  • Van Waes C, Nuclear factor-kappaB in development, prevention, and therapy of cancer.Clin. Cancer Res. 13 (2007) 1076–1082.,
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  • Schwab M, Reynders V, Loitsch S, Steinhilber D, Stein J, Schroder O, Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling Mol.Immunol. 44 (2007) 3625–3632.
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VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?

Year 2014, Volume: 1 Issue: 1, 34 - 47, 16.12.2014

Abstract

 Özet

Vitamin D, kemik metabolizması haricinde birçok hastalık ve kansere karşı potansiyel koruyucu etkileri vardır. Hücre proliferasyonu, apopitozu, inflamasyon ve angiogenez üzerinden kanser insidansı, progresyonu ve bazı kanser tiplerinde mortaliteye karşı vitamin D’nin koruyucu etiklerine ait veriler giderek artmaktadır. Meme kanseri, prostat kanseri, gastrointestinal kanserler açısından  epidemiyolojik veriler ve preklinik bulgular Vitamin D’nin kanser gelişimi ve progresyonundaki rollerini desteklemektedir. 

Anahtar kelimeler: Vitamin D, kanser, dehidrokolekalsiferol

 DOES VITAMIN D CAUSE TO CANCER?

Vitamin D has a potential protective effects against cancer and some diseases except bone metabolism. Data  about the protective  effects of  vitamin D against cancer incidence, progression and mortality of different types  which are due to cell proliferatiton, apaptozis, inflammation and angiogenesis, have increased. The epidemiologycal data and preclinical findings support the role of vitamin D at cancer development and progression in relation to breast, prostat and colorectal cancers.

Key words:Vitamin D, cancer, dehidrocolecalsiferol

References

  • Mocellin S. Vitamin D and cancer: Deciphering the truth. Biochimica et Biophysica Acta 1816 (2011) 172–178
  • Krishnan AV, Feldman D, Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D.Annu. Rev. Pharmacol. Toxicol. 2011;51:311-36.
  • Peterlik M, Cross HS, Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur. J. Clin. Nutr. 63 (2009) 1377–1386.
  • Garland F, Gorham ED, Mohr SB, Garland FC, Vitamin D for cancer prevention: global perspective.Ann. Epidemiol. 19 (2009) 468–483
  • Krishnan AV, Trump DL, Johnson CS, Feldman D, The role of vitamin D in cancer prevention and treatment. Endocrinol. Metab. Clin. North Am. 39 (2010) 401–418.
  • Deeb KK, Trump DL, Johnson CS, Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.Nat. Rev. Cancer 7 (2007) 684–700.
  • Campbell MJ, Elstner E, Holden S, Uskokovic M, Koeffler HP, Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.J. Mol. Endocrinol.19 (1997) 15–27.
  • Holick MF,The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 29(6) (2008): 361–8.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2011) ;96(7):1911–30.
  • Adams JS and Hewison M, Update in Vitamin D. J Clin Endocrinol Metab (2010);95(2): 471–478.
  • Holick MF, Vitamin D Deficiency. N Engl J Med 357: 266–281.Metab (2007);95(2): 471–478.
  • Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, et al. The nonskeletal effects of vitamin D: an Endocrine Society Scientific statement. Endocr Rev (2012);33(3): 456–92.
  • Giovannucci E, Expanding roles of vitamin D. J Clin Endocrinol Metab 2009;94: 418–420.
  • Garland CF, Gorham ED, Mohr SB, Garland FC,Vitamin D for cancer prevention: global perspective. Ann Epidemiol (2009);19: 468–483.
  • Hossein-Nezhad A, Spira A, Holick MF. Influence of vitamin d status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.PLoS One. 2013;8(3):e58725. doi:10.1371/journal.pone.0058725
  • Yang ES, Burnstein KL, Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. J. Biol. Chem. 278 (2003) 46862–46868.
  • Verlinden L, Verstuyf A, Convents R, Marcelis S, Van Camp M, Bouillon R, Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells.Mol.Cell. Endocrinol. 142 (1998) 57–65.
  • Jensen SS, Madsen MW, Lukas J, Binderup L, Bartek J, Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery.Mol. Endocrinol. 15 (2001) 1370–1380.
  • Boyle BJ, Zhao XY, Cohen P, Feldman D, Insulin-like growth factor binding protein-3 mediates 1 alpha,25-dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1. J. Urol. 165 (2001) 1319–1324.
  • Peng L, Malloy PJ, Feldman D, Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter.Mol. Endocrinol. 18 (2004) 1109–1119.
  • Palmer HG, Sanchez-Carbayo M, Ordonez-Moran P, Larriba MJ, Cordon-Cardo C, Munoz A, Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.Cancer Res. 63 (2003) 7799–7806.
  • Li P, Li C, Zhao X, Zhang X, Nicosia SV, Bai W, p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase.J. Biol. Chem. 279 (2004)25260–25267
  • Ma Y, Yu WD, Hershberger PA, Flynn G, Kong RX, Trump DL, Johnson CS, 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model.Mol. Cancer Ther. 7 (2008) 3047–3055.
  • Blutt SE, McDonnell TJ, Polek TC, Weigel NL, Endocrinology 141 (2000) 10–17.
  • Narvaez CJ, Welsh J, Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells.J. Biol. Chem. 276 (2001) 9101–9107
  • Jiang F, Bao J, Li P, Nicosia SV, Bai W, Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase.J. Biol. Chem. 279 (2004) 53213–53221.
  • Hoyer-Hansen M, Nordbrandt SP, Jaattela M, Autophagy as a basis for the health-promoting effects of vitamin D.Trends Mol. Med. 16 (2010) 295–302.
  • Pan L, Matloob AF, Du J, Pan H, Dong Z, Zhao J, Feng Y, Zhong Y, Huang B, Lu J, Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.FEBS J. 277 (2010) 989–999.
  • Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE, Circ. Res. 87(2000) 214–220.
  • Ben-Shoshan M, Amir S, Dang DT, Dang LH, Weisman Y, Mabjeesh NJ, Mol. 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells.Cancer Ther. 6 (2007) 1433–1439.
  • Chung I, Han G, Seshadri M, Gillard BM, Yu WD, Foster BA, Trump DL, Johnson CS, Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo.Cancer Res. 69 (2009) 967–975.
  • Bao BY, Yao J, Lee YF, 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.Carcinogenesis 27 (2006) 1883–1893.
  • Aparna R, Subhashini J, Roy KR, Reddy GS, Robinson M, Uskokovic MR, Venkateswara Reddy G, Reddanna P, Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. J. Cell. Biochem. 104 (2008) 1832–1842.
  • Agarwal S, Reddy GV, Reddanna P, Eicosanoids in inflammation and cancer: the role of COX-2. Expert Rev. Clin. Immunol. 5 (2009)145–165.
  • Chung I, Wong MK, Flynn G, Yu WD, Johnson CS, Trump DL, Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells.Cancer Res. 66 (2006) 8565–8573.
  • Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, Kuo WL, Gray JW, Pinkel D, Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene.Nat. Genet. 25 (2000) 144–146.
  • King AN, Beer DG, Christensen PJ, Simpson RU, Ramnath N, The vitamin D/CYP24A1 story in cancer.Anticancer Agents Med Chem. 10 (2010) 213–224.
  • Koli K, Keski-Oja J, 1alpha,25-dihydroxyvitamin D3 and its analogues down-regulate cell invasion-associated proteases in cultured malignant cells.Cell Growth Differ. 11 (2000) 221–229.
  • Gonzalez-Sancho JM, Alvarez-Dolado M, Munoz A, 1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells. FEBS Lett. 426 (1998) 225–228.
  • Sung V, Feldman D, 1,25-Dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration. Mol. Cell. Endocrinol. 164 (2000) 133–143
  • Mantovani A, . Molecular pathways linking inflammation and cancer.Curr. Mol. Med. 10 (2010) 369–373
  • Krishnan AV, Shinghal R, Raghavachari N, Brooks JD, Peehl DM, Feldman D, Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays.Prostate 59 (2004) 243–251.
  • Van Waes C, Nuclear factor-kappaB in development, prevention, and therapy of cancer.Clin. Cancer Res. 13 (2007) 1076–1082.,
  • Sun J, Kong J, Duan Y, Szeto FL, Liao A, Madara JL, Li YC, . Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor.Am. J. Physiol. Endocrinol. Metab. 291 (2006) E315–E322
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There are 75 citations in total.

Details

Primary Language tr,en
Journal Section Makaleler
Authors

Sevil Uygun İlikhan This is me

Fatih Kuzu

Muammer Bilici

Taner Bayraktaroğlu

Publication Date December 16, 2014
Published in Issue Year 2014 Volume: 1 Issue: 1

Cite

APA Uygun İlikhan, S., Kuzu, F., Bilici, M., Bayraktaroğlu, T. (2014). VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, 1(1), 34-47.
AMA Uygun İlikhan S, Kuzu F, Bilici M, Bayraktaroğlu T. VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. December 2014;1(1):34-47.
Chicago Uygun İlikhan, Sevil, Fatih Kuzu, Muammer Bilici, and Taner Bayraktaroğlu. “VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 1, no. 1 (December 2014): 34-47.
EndNote Uygun İlikhan S, Kuzu F, Bilici M, Bayraktaroğlu T (December 1, 2014) VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 1 1 34–47.
IEEE S. Uygun İlikhan, F. Kuzu, M. Bilici, and T. Bayraktaroğlu, “VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?”, Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, vol. 1, no. 1, pp. 34–47, 2014.
ISNAD Uygun İlikhan, Sevil et al. “VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM 1/1 (December 2014), 34-47.
JAMA Uygun İlikhan S, Kuzu F, Bilici M, Bayraktaroğlu T. VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. 2014;1:34–47.
MLA Uygun İlikhan, Sevil et al. “VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?”. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM, vol. 1, no. 1, 2014, pp. 34-47.
Vancouver Uygun İlikhan S, Kuzu F, Bilici M, Bayraktaroğlu T. VİTAMİN D KANSERDEN SORUMLU MU? DOES VITAMIN D CAUSE TO CANCER?. Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Dergisi Medi ForuM. 2014;1(1):34-47.