Relationship between Serum Fetuin-B Level and Metabolic Parameters in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Year 2025, , 75 - 80, 15.01.2025

Canan Karan , Mehmet Çalan , Arif Yüksel , Oktay Bilgir , Giray Bozkaya , Emre Gezer

https://doi.org/10.37990/medr.1496137

Abstract

Aim: Fetuin-B, which is part of the fetuin family, has been demonstrated to be related with the emergence of insulin resistance. Here, we examined the relationship between metabolic parameters in treatment-naive patients with diabetes and fetuin B levels in serum.
Material and Method: Individuals aged 30-65 years old who were diagnosed with newly diagnosed diabetes mellitus, had no chronic disease history, and provided informed consent were enrolled in the study. The clinical parameters were examined.
Results: Forty recently diagnosed type 2 diabetic individuals and 43 controls were analyzed in this study. A significant difference was displayed for waist circumference, serum high-density lipoprotein, low-density lipoprotein, alanine transaminase, homeostatic model assessment for insulin resistance, high-sensitivity C-reactive protein, and carotid intima-media thickness (CIMT) between the two groups. The level of serum fetuin-B was determined to be statistically significantly reduced in diabetic patients compared to that in the serum of the controls. In the diabetic group, we showed a negative correlation between CIMT and fetuin-B (p=0.035).
Conclusion: Fetuin-B levels were considerably lower in recently diagnosed type 2 diabetics as equated with those in the control group who had normal glucose levels. Additionally, an inverse association between CIMT and fetuin-B levels among individuals with recently diagnosed type 2 diabetes mellitus.

Keywords

Carotid intima-media thickness, fetuin-B, metabolic parameters, type 2 diabetes mellitus

Ethical Statement

Local ethics approval was obtained upon decision of 18.08.2015 No: 2 from the Non-Interventional Clinical Research Ethics Committee of Izmir Bozyaka Training and Research Hospital.

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