Research Article
BibTex RIS Cite

A Morphometric Examination of The Orbita Structure in Schizophrenia Patients: A Retrospective Study

Year 2025, , 195 - 200, 15.01.2025
https://doi.org/10.37990/medr.1586908

Abstract

Aim: To compare the orbita anthropometric measurement values of individuals diagnosed with schizophrenia with those of a healthy control group.
Material and Method: The study included 156 participants as 75 schizophrenia patients and 81 healthy control subjects, all with previous cranial computed tomography imaging. The orbita morphometric values were calculated of all the participants. Statistical comparisons were made between the groups of the mean values of the measurements. The Kolmogorov-Smirnov test was used to evaluate the conformity of continuous variables to normal distribution. Paired groups were compared with the Student’s t-test.
Results: Statistically significantly higher left orbita height was determined in the schizophrenia patient group compared to the control group (p=0.001), and the values of the right orbita lateral wall length (p=0.042), left lateral wall length (p=0.033), and left medial wall length (p=0.014) were statisically significantly lower. Female schizophrenia patients were found to have significantly lower values of right orbita height (p=0.031), right orbita width (p=0.022), left orbita height (p=0.007), left orbita width (p=0.002), right orbita area (p<0.001), left orbita area (p=0.023), bimalar width (p<0.001), left optic nerve-sheath width (p=0.021), and skull transverse diameter (p<0.001) compared to males. There was determined to be a significant positive correlation between age and the right orbita width and the interorbital width measurements (p=0.011, r=0.203; p=0.015, r=0.194, respectively).
Conclusion: These findings can be considered useful in respect of better undertanding the orbita structure of schizophrenia patients.

References

  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Washington DC, American Psychiatric Association. 2013.
  • Orsolini L, Pompili S, Volpe U. Schizophrenia: a narrative review of etiopathogenetic, diagnostic and treatment aspects. J Clin Med. 2022;11:5040.
  • Trifu SC, Kohn B, Vlasie A, Patrichi BE. Genetics of schizophrenia (Review). Exp Ther Med. 2020;20:3462-8.
  • Eyles DW. How do established developmental risk-factors for schizophrenia change the way the brain develops?. Transl Psychiatry. 2021;11:158.
  • Tsuang M. Schizophrenia: genes and environment. Biol Psychiatry. 2000;47:210-20.
  • Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull. 2009;35:528-48.
  • Keshavan MS. Development, disease and degeneration in schizophrenia: a unitary pathophysiological model. J Psychiatr Res. 1999;33:513-21.
  • Elizarraras–Rivas J, Fragoso-Herrera R, CerdanSanchez LF, et al. Minor physical anomalies and anthropometric measures in schizophrenia: a pilot study from Mexico. Schizophr Res. 2003;62:285-87.
  • Demir M, Atay E, Tümer MK, et al. Craniofacial morphometry of schizophrenia patients. Annals Health Sci Ress. 2017;6:10-8.
  • Compton MT, Walker EF. Physical manifestations of neurodevelopmental disruption: are minor physical anomalies part of the syndrome of schizophrenia?. Schizophr Bull. 2009;35:425-36.
  • Lloyd T, Dazzan P, Dean K, et al. Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity. Psychol Med. 2008;38:71-7.
  • Gaca PJ, Lewandowicz M, Lipczynska-Lewandowska M, et al. Embryonic development of the orbit. Klin Monbl Augenheilkd. 2022;239:19-26.
  • Bilkay C, Koyuncu E, Dursun A, et al. Development of the orbit and eyeball during the fetal period. Med Records. 2023;5:314-9.
  • Fakhroddin M, Ahmad G, Imran S. Morphometric characteristics of craniofacial features in patients with schizophrenia. J Psychiatry. 2014;17:514-9.
  • Lin AS, Chang SS, Lin SH, Minor physical anomalies and craniofacial measures in patients with treatment-resistant schizophrenia. Psychol Med. 2015;45:1839-50.
  • Hennessy RJ, Kinsella A, Waddington JL. 3D Laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism. Biol Psychiatry. 2002;5:507-14.
  • Rajangam S, Kulkarni R, Quadrilos L, Sreenivasulu S. Orbital dimensions. Indian J Anat. 2012;1:5-9.
  • Nitek S, Wysocki J, Reymond J, Piasecki K. Correlations between selected parameters of the human skull and orbit. Med Sci Monit. 2009;15:BR370-7.
  • Oester AE Jr, Sahu P, Fowler B, Fleming JC. Radiographic predictors of visual outcome in orbital compartment syndrome. Ophthalmic Plast Reconstr Surg. 2012;28:7-10.
  • Attia AM, Ghoneim M, Elkhamary SM. Sex discrimination from orbital aperture dimensions using computed tomography: Sample of Egyptian population. J Forensic Radiol Imaging. 2019;27:1-12.
  • Can AR, Korkmaz İ, Atamtürk D, et al. The use of width measurements taken from the upper face and orbital regions in sex determination. MKÜ Tıp Derg. 2022;13:296-302.
  • Bulut S, Taş F, Atalar M, Dökmetaş S. Graves’ hastalığında orbita tutulumunun bilgisayarlı tomografi ile değerlendirilmesi. Cumhuriyet Medical Journal. 2002;24:123-7.
  • Demirtaş İ. Üç boyutlu multidedektör bilgisayarlı tomografide orbita ve orbital yapıların morfometrik analizi. MSc Thesis. Afyon Kocatepe Üniversitesi, Afyonkarahisar, 2014.
  • Nafiaa H, Benchikhi L, Ouanass A. Morphological abnormalities in schizophrenia: systematic review. SAS J Med. 2022;5:376-83.
  • Sut E, Akgül Ö, Bora E. Minor physical anomalies in schizophrenia and first-degree relatives in comparison to healthy controls: a systematic review and meta-analysis. Euro Neuropsychopharmacol. 2024;86:55-64.
  • Priol AC, Denis L, Boulanger G, et al. Detection of morphological abnormalities in schizophrenia: an important step to identify associated genetic disorders or etiologic subtypes. Int J Mol Sci. 2021;22:9464.
  • Naqvi S, Sleyp Y, Hoskens H, et al. Shared heritability of human face and brain shape. Nat Genetics. 2021;53:830-9.
  • Tsehay B, Seyoum G. The neurodevelopmental basis of schizophrenia: clinical clues from craniofacial dysmorphology in Northwest Ethiopia, 2020. BMC Neurosci. 2021;22:59.
  • Vogele D, Sollmann N, Beck A, et al. Orbital tumors-clinical, radiologic and histopathologic correlation. Diagnostics (Basel). 2022;12:2376.
  • Erdem H, Tekeli M, Cevik Y, et al. Three-dimensional (3D) analysis of orbital morphometry in healthy Anatolian adults: sex, side discrepancies, and clinical relevance. Cureus. 2023;15:e45208.
  • Pirinç B, Fazlıoğulları Z, Koplay M, et al. Morphometric analysis of orbit in Turkish population: a MDCT study. Genel Tıp Derg. 2022;32:590-600.
  • Khani H, Fazelinejad Z, Hanafi MG, et al. Morphometric and volumetric evaluations of orbit using three-dimensional computed tomography in southwestern Iranian population. Transl Res Anatomy. 2023;30:100233.
  • Muhammed FK, Abdullah AO, Liu Y. A morphometric study of the sella turcica: race, age, and gender effect. Folia Morpholog. 2020;79:318-26.
  • Ranganath A, Saklecha AK, Singh A, Vineela, E. Age and gender differences in morphometric measurements of brain stem using magnetic resonance imaging in healthy Indian adults. J Datta Meghe Institute Med Sci Univ. 2022;17:21-4.
  • Douglas RS, Kahaly GJ, Patel A, et al. Teprotumumab for the treatment of active thyroid eye disease. N Engl J Med. 2020;382:341-52.
Year 2025, , 195 - 200, 15.01.2025
https://doi.org/10.37990/medr.1586908

Abstract

References

  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Washington DC, American Psychiatric Association. 2013.
  • Orsolini L, Pompili S, Volpe U. Schizophrenia: a narrative review of etiopathogenetic, diagnostic and treatment aspects. J Clin Med. 2022;11:5040.
  • Trifu SC, Kohn B, Vlasie A, Patrichi BE. Genetics of schizophrenia (Review). Exp Ther Med. 2020;20:3462-8.
  • Eyles DW. How do established developmental risk-factors for schizophrenia change the way the brain develops?. Transl Psychiatry. 2021;11:158.
  • Tsuang M. Schizophrenia: genes and environment. Biol Psychiatry. 2000;47:210-20.
  • Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull. 2009;35:528-48.
  • Keshavan MS. Development, disease and degeneration in schizophrenia: a unitary pathophysiological model. J Psychiatr Res. 1999;33:513-21.
  • Elizarraras–Rivas J, Fragoso-Herrera R, CerdanSanchez LF, et al. Minor physical anomalies and anthropometric measures in schizophrenia: a pilot study from Mexico. Schizophr Res. 2003;62:285-87.
  • Demir M, Atay E, Tümer MK, et al. Craniofacial morphometry of schizophrenia patients. Annals Health Sci Ress. 2017;6:10-8.
  • Compton MT, Walker EF. Physical manifestations of neurodevelopmental disruption: are minor physical anomalies part of the syndrome of schizophrenia?. Schizophr Bull. 2009;35:425-36.
  • Lloyd T, Dazzan P, Dean K, et al. Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity. Psychol Med. 2008;38:71-7.
  • Gaca PJ, Lewandowicz M, Lipczynska-Lewandowska M, et al. Embryonic development of the orbit. Klin Monbl Augenheilkd. 2022;239:19-26.
  • Bilkay C, Koyuncu E, Dursun A, et al. Development of the orbit and eyeball during the fetal period. Med Records. 2023;5:314-9.
  • Fakhroddin M, Ahmad G, Imran S. Morphometric characteristics of craniofacial features in patients with schizophrenia. J Psychiatry. 2014;17:514-9.
  • Lin AS, Chang SS, Lin SH, Minor physical anomalies and craniofacial measures in patients with treatment-resistant schizophrenia. Psychol Med. 2015;45:1839-50.
  • Hennessy RJ, Kinsella A, Waddington JL. 3D Laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism. Biol Psychiatry. 2002;5:507-14.
  • Rajangam S, Kulkarni R, Quadrilos L, Sreenivasulu S. Orbital dimensions. Indian J Anat. 2012;1:5-9.
  • Nitek S, Wysocki J, Reymond J, Piasecki K. Correlations between selected parameters of the human skull and orbit. Med Sci Monit. 2009;15:BR370-7.
  • Oester AE Jr, Sahu P, Fowler B, Fleming JC. Radiographic predictors of visual outcome in orbital compartment syndrome. Ophthalmic Plast Reconstr Surg. 2012;28:7-10.
  • Attia AM, Ghoneim M, Elkhamary SM. Sex discrimination from orbital aperture dimensions using computed tomography: Sample of Egyptian population. J Forensic Radiol Imaging. 2019;27:1-12.
  • Can AR, Korkmaz İ, Atamtürk D, et al. The use of width measurements taken from the upper face and orbital regions in sex determination. MKÜ Tıp Derg. 2022;13:296-302.
  • Bulut S, Taş F, Atalar M, Dökmetaş S. Graves’ hastalığında orbita tutulumunun bilgisayarlı tomografi ile değerlendirilmesi. Cumhuriyet Medical Journal. 2002;24:123-7.
  • Demirtaş İ. Üç boyutlu multidedektör bilgisayarlı tomografide orbita ve orbital yapıların morfometrik analizi. MSc Thesis. Afyon Kocatepe Üniversitesi, Afyonkarahisar, 2014.
  • Nafiaa H, Benchikhi L, Ouanass A. Morphological abnormalities in schizophrenia: systematic review. SAS J Med. 2022;5:376-83.
  • Sut E, Akgül Ö, Bora E. Minor physical anomalies in schizophrenia and first-degree relatives in comparison to healthy controls: a systematic review and meta-analysis. Euro Neuropsychopharmacol. 2024;86:55-64.
  • Priol AC, Denis L, Boulanger G, et al. Detection of morphological abnormalities in schizophrenia: an important step to identify associated genetic disorders or etiologic subtypes. Int J Mol Sci. 2021;22:9464.
  • Naqvi S, Sleyp Y, Hoskens H, et al. Shared heritability of human face and brain shape. Nat Genetics. 2021;53:830-9.
  • Tsehay B, Seyoum G. The neurodevelopmental basis of schizophrenia: clinical clues from craniofacial dysmorphology in Northwest Ethiopia, 2020. BMC Neurosci. 2021;22:59.
  • Vogele D, Sollmann N, Beck A, et al. Orbital tumors-clinical, radiologic and histopathologic correlation. Diagnostics (Basel). 2022;12:2376.
  • Erdem H, Tekeli M, Cevik Y, et al. Three-dimensional (3D) analysis of orbital morphometry in healthy Anatolian adults: sex, side discrepancies, and clinical relevance. Cureus. 2023;15:e45208.
  • Pirinç B, Fazlıoğulları Z, Koplay M, et al. Morphometric analysis of orbit in Turkish population: a MDCT study. Genel Tıp Derg. 2022;32:590-600.
  • Khani H, Fazelinejad Z, Hanafi MG, et al. Morphometric and volumetric evaluations of orbit using three-dimensional computed tomography in southwestern Iranian population. Transl Res Anatomy. 2023;30:100233.
  • Muhammed FK, Abdullah AO, Liu Y. A morphometric study of the sella turcica: race, age, and gender effect. Folia Morpholog. 2020;79:318-26.
  • Ranganath A, Saklecha AK, Singh A, Vineela, E. Age and gender differences in morphometric measurements of brain stem using magnetic resonance imaging in healthy Indian adults. J Datta Meghe Institute Med Sci Univ. 2022;17:21-4.
  • Douglas RS, Kahaly GJ, Patel A, et al. Teprotumumab for the treatment of active thyroid eye disease. N Engl J Med. 2020;382:341-52.
There are 35 citations in total.

Details

Primary Language English
Subjects Ophthalmology and Optometry (Other), Psychiatry, Anatomy
Journal Section Original Articles
Authors

Sinem Keser 0000-0002-9181-6691

Sevler Yıldız 0000-0002-9951-9093

Elif Emre 0000-0001-5659-3499

Publication Date January 15, 2025
Submission Date November 25, 2024
Acceptance Date December 28, 2024
Published in Issue Year 2025

Cite

AMA Keser S, Yıldız S, Emre E. A Morphometric Examination of The Orbita Structure in Schizophrenia Patients: A Retrospective Study. Med Records. January 2025;7(1):195-200. doi:10.37990/medr.1586908

 Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Turkey

Editors
Assoc. Prof. Serkan Öner
İzmir Bakırçay University, Department of Radiology, İzmir, Türkiye

E-mail: medrecsjournal@gmail.com

Publisher:
Medical Records Association (Tıbbi Kayıtlar Derneği)
Address: Orhangazi Neighborhood, 440th Street,
Green Life Complex, Block B, Floor 3, No. 69
Düzce, Türkiye
Web: www.tibbikayitlar.org.tr

Publication Support: 

Effect Publishing & Agency
Phone: + 90 (540) 035 44 35
E-mail: info@effectpublishing.com
Address: Akdeniz Neighborhood, Şehit Fethi Bey Street,
No: 66/B, Ground floor, 35210 Konak/İzmir, Türkiye
web: www.effectpublishing.com