Research Article

The Relationship Between High Altitude and Cardiovascular Mortality Rates

Number: 1 February 1, 2026
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The Relationship Between High Altitude and Cardiovascular Mortality Rates

Abstract

Aim: This study aims to determine whether there is a significant correlation between altitude and cardiovascular disease(CVD) mortality rates using publicly available data from 81 provinces in Türkiye. Material and Methods: The data in this study were obtained from publicly available provincial data of the Turkish Statistical Institute (TUIK). The data were analyzed using Spearman correlation and linear regression via SPSS 25.0. The significance threshold was set at p<0.05. Results: A statistically significant negative correlation was observed between altitude and cardiovascular mortality rates (r = -0.220, p = 0.048). Regression analysis, however, indicated that altitude alone explained only 1.9% of the variance in CVD death rates (Adj. R2 = 0.019, p = 0.224). Conclusion: While there is a weak but statistically significant inverse relationship between altitude and cardiovascular mortality rates in Turkey, altitude alone is not a strong predictor. Further multifactorial studies are needed to elucidate additional environmental and socioeconomic contributors.

Keywords

References

  1. Mensah GA, Fuster V, Murray CJL, Roth GA; Global Burden of Cardiovascular Diseases and Risks Collaborators. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. J Am Coll Cardiol. 2023;82(25):2350-2473. doi:10.1016/j.jacc.2023.11.007
  2. Al-Kindi SG, Brook RD, Biswal S, Rajagopalan S. Environmental determinants of cardiovascular disease: lessons learned from air pollution. Nat Rev Cardiol. 2020;17(10):656-672. doi:10.1038/s41569-020-0371-2
  3. Bernabe-Ortiz A, Carrillo-Larco RM. Urbanization, Altitude and Cardiovascular Risk. Glob Heart. 2022;17(1):42. Published 2022 Jun 21. doi:10.5334/gh.1130
  4. Abrignani MG, Lombardo A, Braschi A, Renda N, Abrignani V. Climatic influences on cardiovascular diseases. World J Cardiol. 2022;14(3):152-169. doi:10.4330/wjc.v14.i3.152
  5. Wang T, Li Y, Zheng X. Association of socioeconomic status with cardiovascular disease and cardiovascular risk factors: a systematic review and meta-analysis. Z Gesundh Wiss. Published online January 21, 2023. doi:10.1007/s10389-023-01825-4
  6. Mallet RT, Manukhina EB, Ruelas SS, Caffrey JL, Downey HF. Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential. Am J Physiol Heart Circ Physiol. 2018;315(2):H216-H232. doi:10.1152/ajpheart.00060.2018
  7. Richalet JP, Hermand E, Lhuissier FJ. Cardiovascular physiology and pathophysiology at high altitude. Nat Rev Cardiol. 2024;21(2):75-88. doi:10.1038/s41569-023-00924-9
  8. Villegas-Abrill CB, Vidal-Espinoza R, Gomez-Campos R, et al. Diagnostic Criteria for Metabolic Syndrome in High-Altitude Regions: A Systematic Review. Medicina (Kaunas). 2022;58(3):451. Published 2022 Mar 21. doi:10.3390/medicina58030451

Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Research Article

Publication Date

February 1, 2026

Submission Date

April 6, 2025

Acceptance Date

June 20, 2025

Published in Issue

Year 2026 Number: 1

APA
İmre, G. (2026). The Relationship Between High Altitude and Cardiovascular Mortality Rates. Medical Records, 1. https://doi.org/10.37990/medr.1670804
AMA
1.İmre G. The Relationship Between High Altitude and Cardiovascular Mortality Rates. Med Records. 2026;(1). doi:10.37990/medr.1670804
Chicago
İmre, Gürkan. 2026. “The Relationship Between High Altitude and Cardiovascular Mortality Rates”. Medical Records, no. 1. https://doi.org/10.37990/medr.1670804.
EndNote
İmre G (February 1, 2026) The Relationship Between High Altitude and Cardiovascular Mortality Rates. Medical Records 1
IEEE
[1]G. İmre, “The Relationship Between High Altitude and Cardiovascular Mortality Rates”, Med Records, no. 1, Feb. 2026, doi: 10.37990/medr.1670804.
ISNAD
İmre, Gürkan. “The Relationship Between High Altitude and Cardiovascular Mortality Rates”. Medical Records. 1 (February 1, 2026). https://doi.org/10.37990/medr.1670804.
JAMA
1.İmre G. The Relationship Between High Altitude and Cardiovascular Mortality Rates. Med Records. 2026. doi:10.37990/medr.1670804.
MLA
İmre, Gürkan. “The Relationship Between High Altitude and Cardiovascular Mortality Rates”. Medical Records, no. 1, Feb. 2026, doi:10.37990/medr.1670804.
Vancouver
1.Gürkan İmre. The Relationship Between High Altitude and Cardiovascular Mortality Rates. Med Records. 2026 Feb. 1;(1). doi:10.37990/medr.1670804