Research Article

Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats

Number: 1 March 24, 2026
TR EN

Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats

Abstract

Aim: Renal ischaemia/reperfusion (I/R) injury, which is an important contributing factor to acute kidney damage, leading to increased morbidity and mortality. Olive leaf extract (OLE) possesses antioxidant and anti-inflammatory properties due to its rich polyphenolic content. This study comprehensively investigates the protective effects of OLE obtained from the Memecik variety of olive leaves against renal I/R injury, evaluated by employing two different doses. Material and Methods: A total of 32 male Wistar albino rats were randomly divided into four groups: Sham, Control I/R, I/R+OLE200, and I/R+OLE400. Serum biochemical parameters (urea, creatinine, electrolytes, total antioxidant status [TAS], total oxidant status [TOS], TNF-α, IL-1β, IL-6, and nitric oxide [NO]) and renal tissue histopathology were evaluated. Results: OLE significantly improved serum biochemical parameters, reduced pro-inflammatory cytokines, and enhanced systemic antioxidant capacity, indicated by increased TAS and decreased TOS levels compared to the I/R control group (p<0.05). Histopathologically, OLE groups showed significantly less renal tubular damage and necrosis compared to the control I/R group (p<0.001), with a more pronounced protective effect observed at 400 mg/kg/day. Conclusion: OLE from the Memecik variety exhibits potent protective effects against renal I/R injury. This study is the first comprehensive dose-comparative investigation demonstrating that pre-treatment with OLE significantly mitigates renal damage, inflammation, and oxidative stress, suggesting its potential therapeutic application in clinical settings prone to renal ischaemic damage.

Keywords

Supporting Institution

none

Project Number

none

Ethical Statement

The study was initiated with permission dated 02.06.2022 and reference number AKÜHADYEK 49533702/65.

Thanks

none

References

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Details

Primary Language

English

Subjects

Nefroloji

Journal Section

Research Article

Publication Date

March 24, 2026

Submission Date

November 13, 2025

Acceptance Date

December 17, 2025

Published in Issue

Year 2026 Number: 1

APA
Sarıtaş, H., Görücü Özbek, F., Demirel, H. H., Bülbül, A., Koç, Y., Kanat, M., & Sarıtaş, Z. (2026). Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats. Medical Records, 1. https://doi.org/10.37990/medr.1822657
AMA
1.Sarıtaş H, Görücü Özbek F, Demirel HH, et al. Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats. Med Records. 2026;(1). doi:10.37990/medr.1822657
Chicago
Sarıtaş, Hazen, Fatma Görücü Özbek, Hasan Hüseyin Demirel, et al. 2026. “Protective Effect of Olive Leaf Extract on Renal Ischemia Reperfusion Injury in Rats”. Medical Records, no. 1. https://doi.org/10.37990/medr.1822657.
EndNote
Sarıtaş H, Görücü Özbek F, Demirel HH, Bülbül A, Koç Y, Kanat M, Sarıtaş Z (March 1, 2026) Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats. Medical Records 1
IEEE
[1]H. Sarıtaş et al., “Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats”, Med Records, no. 1, Mar. 2026, doi: 10.37990/medr.1822657.
ISNAD
Sarıtaş, Hazen - Görücü Özbek, Fatma - Demirel, Hasan Hüseyin - Bülbül, Aziz - Koç, Yusuf - Kanat, Murat - Sarıtaş, Zülfükar. “Protective Effect of Olive Leaf Extract on Renal Ischemia Reperfusion Injury in Rats”. Medical Records. 1 (March 1, 2026). https://doi.org/10.37990/medr.1822657.
JAMA
1.Sarıtaş H, Görücü Özbek F, Demirel HH, Bülbül A, Koç Y, Kanat M, Sarıtaş Z. Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats. Med Records. 2026. doi:10.37990/medr.1822657.
MLA
Sarıtaş, Hazen, et al. “Protective Effect of Olive Leaf Extract on Renal Ischemia Reperfusion Injury in Rats”. Medical Records, no. 1, Mar. 2026, doi:10.37990/medr.1822657.
Vancouver
1.Hazen Sarıtaş, Fatma Görücü Özbek, Hasan Hüseyin Demirel, Aziz Bülbül, Yusuf Koç, Murat Kanat, Zülfükar Sarıtaş. Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats. Med Records. 2026 Mar. 1;(1). doi:10.37990/medr.1822657